High-fat Feeding Promotes Obesity via Insulin Receptor/PI3k-Dependent Inhibition of SF-1 VMH Neurons

SF-1-expressing neurons of the ventromedial hypothalamus (VMH) control energy homeostasis, but the role of insulin action in these cells remains undefined. We show that insulin activates PI3-kinase (PI3k) signaling in SF-1 neurons and reduces firing frequency in these cells via activation of K(ATP)-...

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Detalles Bibliográficos
Autores principales: Klöckener, Tim, Hess, Simon, Belgardt, Bengt F., Paeger, Lars, Verhagen, Linda A. W., Husch, Andreas, Sohn, Jong-Woo, Hampel, Brigitte, Dhillon, Harveen, Zigman, Jeffrey M., Lowell, Bradford B., Williams, Kevin W., Elmquist, Joel K., Horvath, Tamas L., Kloppenburg, Peter, Brüning, Jens C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371271/
https://www.ncbi.nlm.nih.gov/pubmed/21642975
http://dx.doi.org/10.1038/nn.2847

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