Cargando…

RASSF1 Polymorphisms in Cancer

Ras association domain family 1A (RASSF1A) is one of the most epigenetically silenced elements in human cancers. Localized on chromosome 3, it has been demonstrated to be a bone fide tumor suppressor influencing cell cycle events, microtubule stability, apoptosis, and autophagy. Although it is epige...

Descripción completa

Detalles Bibliográficos
Autores principales: Gordon, Marilyn, El-Kalla, Mohamed, Baksh, Shairaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371342/
https://www.ncbi.nlm.nih.gov/pubmed/22701175
http://dx.doi.org/10.1155/2012/365213
_version_ 1782235187001688064
author Gordon, Marilyn
El-Kalla, Mohamed
Baksh, Shairaz
author_facet Gordon, Marilyn
El-Kalla, Mohamed
Baksh, Shairaz
author_sort Gordon, Marilyn
collection PubMed
description Ras association domain family 1A (RASSF1A) is one of the most epigenetically silenced elements in human cancers. Localized on chromosome 3, it has been demonstrated to be a bone fide tumor suppressor influencing cell cycle events, microtubule stability, apoptosis, and autophagy. Although it is epigenetically silenced by promoter-specific methylation in cancers, several somatic nucleotide changes (polymorphisms) have been identified in RASSF1A in tissues from cancer patients. We speculate that both nucleotide changes and epigenetic silencing result in loss of the RASSF1A tumor suppressor function and the appearance of enhanced growth. This paper will summarize what is known about the origin of these polymorphisms and how they have helped us understand the biological role of RASSF1A.
format Online
Article
Text
id pubmed-3371342
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-33713422012-06-13 RASSF1 Polymorphisms in Cancer Gordon, Marilyn El-Kalla, Mohamed Baksh, Shairaz Mol Biol Int Review Article Ras association domain family 1A (RASSF1A) is one of the most epigenetically silenced elements in human cancers. Localized on chromosome 3, it has been demonstrated to be a bone fide tumor suppressor influencing cell cycle events, microtubule stability, apoptosis, and autophagy. Although it is epigenetically silenced by promoter-specific methylation in cancers, several somatic nucleotide changes (polymorphisms) have been identified in RASSF1A in tissues from cancer patients. We speculate that both nucleotide changes and epigenetic silencing result in loss of the RASSF1A tumor suppressor function and the appearance of enhanced growth. This paper will summarize what is known about the origin of these polymorphisms and how they have helped us understand the biological role of RASSF1A. Hindawi Publishing Corporation 2012 2012-05-31 /pmc/articles/PMC3371342/ /pubmed/22701175 http://dx.doi.org/10.1155/2012/365213 Text en Copyright © 2012 Marilyn Gordon et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gordon, Marilyn
El-Kalla, Mohamed
Baksh, Shairaz
RASSF1 Polymorphisms in Cancer
title RASSF1 Polymorphisms in Cancer
title_full RASSF1 Polymorphisms in Cancer
title_fullStr RASSF1 Polymorphisms in Cancer
title_full_unstemmed RASSF1 Polymorphisms in Cancer
title_short RASSF1 Polymorphisms in Cancer
title_sort rassf1 polymorphisms in cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371342/
https://www.ncbi.nlm.nih.gov/pubmed/22701175
http://dx.doi.org/10.1155/2012/365213
work_keys_str_mv AT gordonmarilyn rassf1polymorphismsincancer
AT elkallamohamed rassf1polymorphismsincancer
AT bakshshairaz rassf1polymorphismsincancer