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Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship
The interaction between human cytomegalovirus (HCMV) and its host is a complex process that begins with viral attachment and entry into host cells, culminating in the development of a specific adaptive response that clears the acute infection but fails to eradicate HCMV. We review the viral and cell...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371353/ https://www.ncbi.nlm.nih.gov/pubmed/22701276 http://dx.doi.org/10.1155/2012/607276 |
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author | Rossini, Giada Cerboni, Cristina Santoni, Angela Landini, Maria Paola Landolfo, Santo Gatti, Deborah Gribaudo, Giorgio Varani, Stefania |
author_facet | Rossini, Giada Cerboni, Cristina Santoni, Angela Landini, Maria Paola Landolfo, Santo Gatti, Deborah Gribaudo, Giorgio Varani, Stefania |
author_sort | Rossini, Giada |
collection | PubMed |
description | The interaction between human cytomegalovirus (HCMV) and its host is a complex process that begins with viral attachment and entry into host cells, culminating in the development of a specific adaptive response that clears the acute infection but fails to eradicate HCMV. We review the viral and cellular partners that mediate early host responses to HCMV with regard to the interaction between structural components of virions (viral glycoproteins) and cellular receptors (attachment/entry receptors, toll-like receptors, and other nucleic acid sensors) or intrinsic factors (PML, hDaxx, Sp100, viperin, interferon inducible protein 16), the reactions of innate immune cells (antigen presenting cells and natural killer cells), the numerous mechanisms of viral immunoevasion, and the potential exploitation of events that are associated with early phases of virus-host interplay as a therapeutic strategy. |
format | Online Article Text |
id | pubmed-3371353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33713532012-06-13 Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship Rossini, Giada Cerboni, Cristina Santoni, Angela Landini, Maria Paola Landolfo, Santo Gatti, Deborah Gribaudo, Giorgio Varani, Stefania Mediators Inflamm Review Article The interaction between human cytomegalovirus (HCMV) and its host is a complex process that begins with viral attachment and entry into host cells, culminating in the development of a specific adaptive response that clears the acute infection but fails to eradicate HCMV. We review the viral and cellular partners that mediate early host responses to HCMV with regard to the interaction between structural components of virions (viral glycoproteins) and cellular receptors (attachment/entry receptors, toll-like receptors, and other nucleic acid sensors) or intrinsic factors (PML, hDaxx, Sp100, viperin, interferon inducible protein 16), the reactions of innate immune cells (antigen presenting cells and natural killer cells), the numerous mechanisms of viral immunoevasion, and the potential exploitation of events that are associated with early phases of virus-host interplay as a therapeutic strategy. Hindawi Publishing Corporation 2012 2012-05-31 /pmc/articles/PMC3371353/ /pubmed/22701276 http://dx.doi.org/10.1155/2012/607276 Text en Copyright © 2012 Giada Rossini et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rossini, Giada Cerboni, Cristina Santoni, Angela Landini, Maria Paola Landolfo, Santo Gatti, Deborah Gribaudo, Giorgio Varani, Stefania Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship |
title | Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship |
title_full | Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship |
title_fullStr | Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship |
title_full_unstemmed | Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship |
title_short | Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship |
title_sort | interplay between human cytomegalovirus and intrinsic/innate host responses: a complex bidirectional relationship |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371353/ https://www.ncbi.nlm.nih.gov/pubmed/22701276 http://dx.doi.org/10.1155/2012/607276 |
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