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Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches
Hepatic fibrosis (HF) is a progressive condition with serious clinical complications arising from abnormal proliferation and amassing of tough fibrous scar tissue. This defiance of collagen fibers becomes fatal due to ultimate failure of liver functions. Participation of various cell types, interlin...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371417/ https://www.ncbi.nlm.nih.gov/pubmed/22626794 http://dx.doi.org/10.4103/1319-3767.96445 |
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author | Ahmad, Areeba Ahmad, Riaz |
author_facet | Ahmad, Areeba Ahmad, Riaz |
author_sort | Ahmad, Areeba |
collection | PubMed |
description | Hepatic fibrosis (HF) is a progressive condition with serious clinical complications arising from abnormal proliferation and amassing of tough fibrous scar tissue. This defiance of collagen fibers becomes fatal due to ultimate failure of liver functions. Participation of various cell types, interlinked cellular events, and large number of mediator molecules make the fibrotic process enormously complex and dynamic. However, with better appreciation of underlying cellular and molecular mechanisms of fibrosis, the assumption that HF cannot be cured is gradually changing. Recent findings have underlined the therapeutic potential of a number of synthetic compounds as well as plant derivatives for cessation or even the reversal of the processes that transforms the liver into fibrotic tissue. It is expected that future inputs will provide a conceptual framework to develop more specific strategies that would facilitate the assessment of risk factors, shortlist early diagnosis biomarkers, and eventually guide development of effective therapeutic alternatives. |
format | Online Article Text |
id | pubmed-3371417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33714172012-06-13 Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches Ahmad, Areeba Ahmad, Riaz Saudi J Gastroenterol Review Article Hepatic fibrosis (HF) is a progressive condition with serious clinical complications arising from abnormal proliferation and amassing of tough fibrous scar tissue. This defiance of collagen fibers becomes fatal due to ultimate failure of liver functions. Participation of various cell types, interlinked cellular events, and large number of mediator molecules make the fibrotic process enormously complex and dynamic. However, with better appreciation of underlying cellular and molecular mechanisms of fibrosis, the assumption that HF cannot be cured is gradually changing. Recent findings have underlined the therapeutic potential of a number of synthetic compounds as well as plant derivatives for cessation or even the reversal of the processes that transforms the liver into fibrotic tissue. It is expected that future inputs will provide a conceptual framework to develop more specific strategies that would facilitate the assessment of risk factors, shortlist early diagnosis biomarkers, and eventually guide development of effective therapeutic alternatives. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3371417/ /pubmed/22626794 http://dx.doi.org/10.4103/1319-3767.96445 Text en Copyright: © Saudi Journal of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ahmad, Areeba Ahmad, Riaz Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches |
title | Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches |
title_full | Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches |
title_fullStr | Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches |
title_full_unstemmed | Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches |
title_short | Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches |
title_sort | understanding the mechanism of hepatic fibrosis and potential therapeutic approaches |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371417/ https://www.ncbi.nlm.nih.gov/pubmed/22626794 http://dx.doi.org/10.4103/1319-3767.96445 |
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