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Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches

Hepatic fibrosis (HF) is a progressive condition with serious clinical complications arising from abnormal proliferation and amassing of tough fibrous scar tissue. This defiance of collagen fibers becomes fatal due to ultimate failure of liver functions. Participation of various cell types, interlin...

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Detalles Bibliográficos
Autores principales: Ahmad, Areeba, Ahmad, Riaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371417/
https://www.ncbi.nlm.nih.gov/pubmed/22626794
http://dx.doi.org/10.4103/1319-3767.96445
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author Ahmad, Areeba
Ahmad, Riaz
author_facet Ahmad, Areeba
Ahmad, Riaz
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description Hepatic fibrosis (HF) is a progressive condition with serious clinical complications arising from abnormal proliferation and amassing of tough fibrous scar tissue. This defiance of collagen fibers becomes fatal due to ultimate failure of liver functions. Participation of various cell types, interlinked cellular events, and large number of mediator molecules make the fibrotic process enormously complex and dynamic. However, with better appreciation of underlying cellular and molecular mechanisms of fibrosis, the assumption that HF cannot be cured is gradually changing. Recent findings have underlined the therapeutic potential of a number of synthetic compounds as well as plant derivatives for cessation or even the reversal of the processes that transforms the liver into fibrotic tissue. It is expected that future inputs will provide a conceptual framework to develop more specific strategies that would facilitate the assessment of risk factors, shortlist early diagnosis biomarkers, and eventually guide development of effective therapeutic alternatives.
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spelling pubmed-33714172012-06-13 Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches Ahmad, Areeba Ahmad, Riaz Saudi J Gastroenterol Review Article Hepatic fibrosis (HF) is a progressive condition with serious clinical complications arising from abnormal proliferation and amassing of tough fibrous scar tissue. This defiance of collagen fibers becomes fatal due to ultimate failure of liver functions. Participation of various cell types, interlinked cellular events, and large number of mediator molecules make the fibrotic process enormously complex and dynamic. However, with better appreciation of underlying cellular and molecular mechanisms of fibrosis, the assumption that HF cannot be cured is gradually changing. Recent findings have underlined the therapeutic potential of a number of synthetic compounds as well as plant derivatives for cessation or even the reversal of the processes that transforms the liver into fibrotic tissue. It is expected that future inputs will provide a conceptual framework to develop more specific strategies that would facilitate the assessment of risk factors, shortlist early diagnosis biomarkers, and eventually guide development of effective therapeutic alternatives. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3371417/ /pubmed/22626794 http://dx.doi.org/10.4103/1319-3767.96445 Text en Copyright: © Saudi Journal of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ahmad, Areeba
Ahmad, Riaz
Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches
title Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches
title_full Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches
title_fullStr Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches
title_full_unstemmed Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches
title_short Understanding the Mechanism of Hepatic Fibrosis and Potential Therapeutic Approaches
title_sort understanding the mechanism of hepatic fibrosis and potential therapeutic approaches
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371417/
https://www.ncbi.nlm.nih.gov/pubmed/22626794
http://dx.doi.org/10.4103/1319-3767.96445
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