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Reversal of reserpine-induced orofacial dyskinesia and catalepsy by Nardostachys jatamansi

CONTEXT: Reserpine-induced orofacial dyskinesia is an animal model of tardive dyskinesia which may be associated with neurodegeneration and free radical damage. AIM: The aim was to assess the neuroprotective potential and in vivo antioxidant status of alcoholic extract of roots and rhizomes of Nardo...

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Autores principales: Patil, Rupali A., Hiray, Yogesh A., Kasture, Sanjay B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371456/
https://www.ncbi.nlm.nih.gov/pubmed/22701243
http://dx.doi.org/10.4103/0253-7613.96307
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author Patil, Rupali A.
Hiray, Yogesh A.
Kasture, Sanjay B.
author_facet Patil, Rupali A.
Hiray, Yogesh A.
Kasture, Sanjay B.
author_sort Patil, Rupali A.
collection PubMed
description CONTEXT: Reserpine-induced orofacial dyskinesia is an animal model of tardive dyskinesia which may be associated with neurodegeneration and free radical damage. AIM: The aim was to assess the neuroprotective potential and in vivo antioxidant status of alcoholic extract of roots and rhizomes of Nardostachys jatamansi (ANJ) and its triterpenes (TNJ) in reserpine-induced orofacial dyskinesia. MATERIALS AND METHODS: In the present study, repeated treatment with reserpine (1.0 mg/kg) on each other day for a period of 5 days (days 1, 3, and 5) significantly induced vacuous chewing movements (VCMs) and tongue protrusions (TPs) in rats. The effect on reserpine-induced catalepsy was also studied. The effect of ANJ and TNJ on levels of superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSH) and inhibition of lipid peroxidation (LPO) in the forebrain region was assessed. STATISTICAL ANALYSIS: All observations were expressed as mean ± SEM. Statistical analysis was performed by the one-way ANOVA followed by Dunnett's test. P<0.05 was regarded as statistically significant. RESULTS: At the end of the treatment schedule, ANJ and TNJ significantly inhibited reserpine-induced VCM, TP, and catalepsy, and significantly increased the locomotion and rearing in the open-field test. Treatment with ANJ and TNJ exhibited significant elevation in the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSH) and inhibition of lipid peroxidation (LPO) in forebrain region compared to the reserpine treated group. CONCLUSIONS: The study concludes that ANJ and TNJ significantly protected animals against reserpine-induced orofacial dyskinesia as well as catalepsy suggesting its potential value in the treatment of neuroleptic-induced orofacial dyskinesia and Parkinson's disease.
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spelling pubmed-33714562012-06-14 Reversal of reserpine-induced orofacial dyskinesia and catalepsy by Nardostachys jatamansi Patil, Rupali A. Hiray, Yogesh A. Kasture, Sanjay B. Indian J Pharmacol Research Article CONTEXT: Reserpine-induced orofacial dyskinesia is an animal model of tardive dyskinesia which may be associated with neurodegeneration and free radical damage. AIM: The aim was to assess the neuroprotective potential and in vivo antioxidant status of alcoholic extract of roots and rhizomes of Nardostachys jatamansi (ANJ) and its triterpenes (TNJ) in reserpine-induced orofacial dyskinesia. MATERIALS AND METHODS: In the present study, repeated treatment with reserpine (1.0 mg/kg) on each other day for a period of 5 days (days 1, 3, and 5) significantly induced vacuous chewing movements (VCMs) and tongue protrusions (TPs) in rats. The effect on reserpine-induced catalepsy was also studied. The effect of ANJ and TNJ on levels of superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSH) and inhibition of lipid peroxidation (LPO) in the forebrain region was assessed. STATISTICAL ANALYSIS: All observations were expressed as mean ± SEM. Statistical analysis was performed by the one-way ANOVA followed by Dunnett's test. P<0.05 was regarded as statistically significant. RESULTS: At the end of the treatment schedule, ANJ and TNJ significantly inhibited reserpine-induced VCM, TP, and catalepsy, and significantly increased the locomotion and rearing in the open-field test. Treatment with ANJ and TNJ exhibited significant elevation in the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSH) and inhibition of lipid peroxidation (LPO) in forebrain region compared to the reserpine treated group. CONCLUSIONS: The study concludes that ANJ and TNJ significantly protected animals against reserpine-induced orofacial dyskinesia as well as catalepsy suggesting its potential value in the treatment of neuroleptic-induced orofacial dyskinesia and Parkinson's disease. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3371456/ /pubmed/22701243 http://dx.doi.org/10.4103/0253-7613.96307 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Patil, Rupali A.
Hiray, Yogesh A.
Kasture, Sanjay B.
Reversal of reserpine-induced orofacial dyskinesia and catalepsy by Nardostachys jatamansi
title Reversal of reserpine-induced orofacial dyskinesia and catalepsy by Nardostachys jatamansi
title_full Reversal of reserpine-induced orofacial dyskinesia and catalepsy by Nardostachys jatamansi
title_fullStr Reversal of reserpine-induced orofacial dyskinesia and catalepsy by Nardostachys jatamansi
title_full_unstemmed Reversal of reserpine-induced orofacial dyskinesia and catalepsy by Nardostachys jatamansi
title_short Reversal of reserpine-induced orofacial dyskinesia and catalepsy by Nardostachys jatamansi
title_sort reversal of reserpine-induced orofacial dyskinesia and catalepsy by nardostachys jatamansi
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371456/
https://www.ncbi.nlm.nih.gov/pubmed/22701243
http://dx.doi.org/10.4103/0253-7613.96307
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