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Effect of Terminalia catappa on lipid profile in transplanted fibrosarcoma in rats
To evaluate the effect of an antitumor activity of Terminalia catappa on lipid lowering activity in transplanted fibrosarcoma in Wistar albino rats. Methylcholantherene–induced fibrosarcoma was transplanted in rats. After 30(th) day when tumor became palpable, started the treatment of ethanolic extr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371466/ https://www.ncbi.nlm.nih.gov/pubmed/22701253 http://dx.doi.org/10.4103/0253-7613.96345 |
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author | Naitik, Pandya Prakash, Tigari Kotresha, Dupadahalli Rao, Nadendla Rama |
author_facet | Naitik, Pandya Prakash, Tigari Kotresha, Dupadahalli Rao, Nadendla Rama |
author_sort | Naitik, Pandya |
collection | PubMed |
description | To evaluate the effect of an antitumor activity of Terminalia catappa on lipid lowering activity in transplanted fibrosarcoma in Wistar albino rats. Methylcholantherene–induced fibrosarcoma was transplanted in rats. After 30(th) day when tumor became palpable, started the treatment of ethanolic extract of Terminalia catappa by orally (250 and 500 mg/kg) for a period of 20 days. The blood sample was collected on 21(st) day, and the liver and the kidney were also removed for studying the lipid profile in serum and the tissues. The levels of total cholesterol, triglycerides and very low density lipoprotein (VLDL) were markedly elevated and high density lipoprotein (HDL) was markedly decreased in the serum of tumor bearing rats. Significant alterations were also observed in the lipid profile of liver and kidney. These changes were significantly reversed in Terminalia catappa (500 mg/kg) treated animals. The reversal of altered lipid levels to normal values in rats with experimentally induced tumor was showed antitumor activity by Terminalia catappa. |
format | Online Article Text |
id | pubmed-3371466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33714662012-06-14 Effect of Terminalia catappa on lipid profile in transplanted fibrosarcoma in rats Naitik, Pandya Prakash, Tigari Kotresha, Dupadahalli Rao, Nadendla Rama Indian J Pharmacol Short Communication To evaluate the effect of an antitumor activity of Terminalia catappa on lipid lowering activity in transplanted fibrosarcoma in Wistar albino rats. Methylcholantherene–induced fibrosarcoma was transplanted in rats. After 30(th) day when tumor became palpable, started the treatment of ethanolic extract of Terminalia catappa by orally (250 and 500 mg/kg) for a period of 20 days. The blood sample was collected on 21(st) day, and the liver and the kidney were also removed for studying the lipid profile in serum and the tissues. The levels of total cholesterol, triglycerides and very low density lipoprotein (VLDL) were markedly elevated and high density lipoprotein (HDL) was markedly decreased in the serum of tumor bearing rats. Significant alterations were also observed in the lipid profile of liver and kidney. These changes were significantly reversed in Terminalia catappa (500 mg/kg) treated animals. The reversal of altered lipid levels to normal values in rats with experimentally induced tumor was showed antitumor activity by Terminalia catappa. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3371466/ /pubmed/22701253 http://dx.doi.org/10.4103/0253-7613.96345 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Naitik, Pandya Prakash, Tigari Kotresha, Dupadahalli Rao, Nadendla Rama Effect of Terminalia catappa on lipid profile in transplanted fibrosarcoma in rats |
title | Effect of Terminalia catappa on lipid profile in transplanted fibrosarcoma in rats |
title_full | Effect of Terminalia catappa on lipid profile in transplanted fibrosarcoma in rats |
title_fullStr | Effect of Terminalia catappa on lipid profile in transplanted fibrosarcoma in rats |
title_full_unstemmed | Effect of Terminalia catappa on lipid profile in transplanted fibrosarcoma in rats |
title_short | Effect of Terminalia catappa on lipid profile in transplanted fibrosarcoma in rats |
title_sort | effect of terminalia catappa on lipid profile in transplanted fibrosarcoma in rats |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371466/ https://www.ncbi.nlm.nih.gov/pubmed/22701253 http://dx.doi.org/10.4103/0253-7613.96345 |
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