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Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity
BACKGROUND: Strychnos nux-vomica, commonly known as kuchla, contains strychnine and brucine as main constituents. Minor alkaloids present in the seeds are protostrychnine, vomicine, n-oxystrychnine, pseudostrychnine, isostrychnine, chlorogenic acid, and a glycoside. Seeds are used traditionally to t...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371563/ https://www.ncbi.nlm.nih.gov/pubmed/22707864 http://dx.doi.org/10.4103/0975-9476.96523 |
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author | Bhati, Rajesh Singh, Anupama Saharan, Vikas Anand Ram, Veerma Bhandari, Anil |
author_facet | Bhati, Rajesh Singh, Anupama Saharan, Vikas Anand Ram, Veerma Bhandari, Anil |
author_sort | Bhati, Rajesh |
collection | PubMed |
description | BACKGROUND: Strychnos nux-vomica, commonly known as kuchla, contains strychnine and brucine as main constituents. Minor alkaloids present in the seeds are protostrychnine, vomicine, n-oxystrychnine, pseudostrychnine, isostrychnine, chlorogenic acid, and a glycoside. Seeds are used traditionally to treat diabetes, asthma, aphrodisiac and to improve appetite. OBJECTIVE: The present study was aimed to evaluate the various pharmacognostical characters and antidiabetic activity of S. nux-vomica seed. MATERIALS AND METHODS: Pharmacognostical characters were performed as per the WHO guideline. Extraction was carried out in petroleum ether, chloroform, alcohol, hydroalcoholic, aqueous, and phytochemical constituents present in extracts were detected by different chemical tests. Among these extracts hydroalcoholic, aqueous extracts were evaluated for antidiabetic activity on the basis of extractive yield and phytoconstituents, in alloxan-induced diabetic rats using gliclazide as standard. RESULTS: Various analytical values of S. nux-vomica extract were established. Phytoconstituents present in S. nux-vomica extracts were detected. CONCLUSION: S. nux-vomica extracts show antihyperglycemic activity in experimental animals. |
format | Online Article Text |
id | pubmed-3371563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33715632012-06-15 Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity Bhati, Rajesh Singh, Anupama Saharan, Vikas Anand Ram, Veerma Bhandari, Anil J Ayurveda Integr Med Original Research Article BACKGROUND: Strychnos nux-vomica, commonly known as kuchla, contains strychnine and brucine as main constituents. Minor alkaloids present in the seeds are protostrychnine, vomicine, n-oxystrychnine, pseudostrychnine, isostrychnine, chlorogenic acid, and a glycoside. Seeds are used traditionally to treat diabetes, asthma, aphrodisiac and to improve appetite. OBJECTIVE: The present study was aimed to evaluate the various pharmacognostical characters and antidiabetic activity of S. nux-vomica seed. MATERIALS AND METHODS: Pharmacognostical characters were performed as per the WHO guideline. Extraction was carried out in petroleum ether, chloroform, alcohol, hydroalcoholic, aqueous, and phytochemical constituents present in extracts were detected by different chemical tests. Among these extracts hydroalcoholic, aqueous extracts were evaluated for antidiabetic activity on the basis of extractive yield and phytoconstituents, in alloxan-induced diabetic rats using gliclazide as standard. RESULTS: Various analytical values of S. nux-vomica extract were established. Phytoconstituents present in S. nux-vomica extracts were detected. CONCLUSION: S. nux-vomica extracts show antihyperglycemic activity in experimental animals. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3371563/ /pubmed/22707864 http://dx.doi.org/10.4103/0975-9476.96523 Text en Copyright: © Journal of Ayurveda and Integrative Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Article Bhati, Rajesh Singh, Anupama Saharan, Vikas Anand Ram, Veerma Bhandari, Anil Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity |
title | Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity |
title_full | Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity |
title_fullStr | Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity |
title_full_unstemmed | Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity |
title_short | Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity |
title_sort | strychnos nux-vomica seeds: pharmacognostical standardization, extraction, and antidiabetic activity |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371563/ https://www.ncbi.nlm.nih.gov/pubmed/22707864 http://dx.doi.org/10.4103/0975-9476.96523 |
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