Cargando…

Prostate cancer mortality risk in relation to working underground in the Wismut cohort study of German uranium miners, 1970–2003

OBJECTIVE: A recent study and comprehensive literature review has indicated that mining could be protective against prostate cancer. This indication has been explored further here by analysing prostate cancer mortality in the German ‘Wismut’ uranium miner cohort, which has detailed information on th...

Descripción completa

Detalles Bibliográficos
Autores principales: Walsh, Linda, Dufey, Florian, Tschense, Annemarie, Schnelzer, Maria, Sogl, Marion, Kreuzer, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371580/
https://www.ncbi.nlm.nih.gov/pubmed/22685223
http://dx.doi.org/10.1136/bmjopen-2012-001002
_version_ 1782235228822044672
author Walsh, Linda
Dufey, Florian
Tschense, Annemarie
Schnelzer, Maria
Sogl, Marion
Kreuzer, Michaela
author_facet Walsh, Linda
Dufey, Florian
Tschense, Annemarie
Schnelzer, Maria
Sogl, Marion
Kreuzer, Michaela
author_sort Walsh, Linda
collection PubMed
description OBJECTIVE: A recent study and comprehensive literature review has indicated that mining could be protective against prostate cancer. This indication has been explored further here by analysing prostate cancer mortality in the German ‘Wismut’ uranium miner cohort, which has detailed information on the number of days worked underground. DESIGN: An historical cohort study of 58 987 male mine workers with retrospective follow-up before 1999 and prospective follow-up since 1999. SETTING AND PARTICIPANTS: Uranium mine workers employed during the period 1970–1990 in the regions of Saxony and Thuringia, Germany, contributing 1.42 million person-years of follow-up ending in 2003. OUTCOME MEASURE: Simple standardised mortality ratio (SMR) analyses were applied to assess differences between the national and cohort prostate cancer mortality rates and complemented by refined analyses done entirely within the cohort. The internal comparisons applied Poisson regression excess relative prostate cancer mortality risk model with background stratification by age and calendar year and a whole range of possible explanatory covariables that included days worked underground and years worked at high physical activity with γ radiation treated as a confounder. RESULTS: The analysis is based on miner data for 263 prostate cancer deaths. The overall SMR was 0.85 (95% CI 0.75 to 0.95). A linear excess relative risk model with the number of years worked at high physical activity and the number of days worked underground as explanatory covariables provided a statistically significant fit when compared with the background model (p=0.039). Results (with 95% CIs) for the excess relative risk per day worked underground indicated a statistically significant (p=0.0096) small protective effect of −5.59 (−9.81 to −1.36) ×10(−5). CONCLUSION: Evidence is provided from the German Wismut cohort in support of a protective effect from working underground on prostate cancer mortality risk.
format Online
Article
Text
id pubmed-3371580
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BMJ Group
record_format MEDLINE/PubMed
spelling pubmed-33715802012-06-14 Prostate cancer mortality risk in relation to working underground in the Wismut cohort study of German uranium miners, 1970–2003 Walsh, Linda Dufey, Florian Tschense, Annemarie Schnelzer, Maria Sogl, Marion Kreuzer, Michaela BMJ Open Epidemiology OBJECTIVE: A recent study and comprehensive literature review has indicated that mining could be protective against prostate cancer. This indication has been explored further here by analysing prostate cancer mortality in the German ‘Wismut’ uranium miner cohort, which has detailed information on the number of days worked underground. DESIGN: An historical cohort study of 58 987 male mine workers with retrospective follow-up before 1999 and prospective follow-up since 1999. SETTING AND PARTICIPANTS: Uranium mine workers employed during the period 1970–1990 in the regions of Saxony and Thuringia, Germany, contributing 1.42 million person-years of follow-up ending in 2003. OUTCOME MEASURE: Simple standardised mortality ratio (SMR) analyses were applied to assess differences between the national and cohort prostate cancer mortality rates and complemented by refined analyses done entirely within the cohort. The internal comparisons applied Poisson regression excess relative prostate cancer mortality risk model with background stratification by age and calendar year and a whole range of possible explanatory covariables that included days worked underground and years worked at high physical activity with γ radiation treated as a confounder. RESULTS: The analysis is based on miner data for 263 prostate cancer deaths. The overall SMR was 0.85 (95% CI 0.75 to 0.95). A linear excess relative risk model with the number of years worked at high physical activity and the number of days worked underground as explanatory covariables provided a statistically significant fit when compared with the background model (p=0.039). Results (with 95% CIs) for the excess relative risk per day worked underground indicated a statistically significant (p=0.0096) small protective effect of −5.59 (−9.81 to −1.36) ×10(−5). CONCLUSION: Evidence is provided from the German Wismut cohort in support of a protective effect from working underground on prostate cancer mortality risk. BMJ Group 2012-06-08 /pmc/articles/PMC3371580/ /pubmed/22685223 http://dx.doi.org/10.1136/bmjopen-2012-001002 Text en © 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Epidemiology
Walsh, Linda
Dufey, Florian
Tschense, Annemarie
Schnelzer, Maria
Sogl, Marion
Kreuzer, Michaela
Prostate cancer mortality risk in relation to working underground in the Wismut cohort study of German uranium miners, 1970–2003
title Prostate cancer mortality risk in relation to working underground in the Wismut cohort study of German uranium miners, 1970–2003
title_full Prostate cancer mortality risk in relation to working underground in the Wismut cohort study of German uranium miners, 1970–2003
title_fullStr Prostate cancer mortality risk in relation to working underground in the Wismut cohort study of German uranium miners, 1970–2003
title_full_unstemmed Prostate cancer mortality risk in relation to working underground in the Wismut cohort study of German uranium miners, 1970–2003
title_short Prostate cancer mortality risk in relation to working underground in the Wismut cohort study of German uranium miners, 1970–2003
title_sort prostate cancer mortality risk in relation to working underground in the wismut cohort study of german uranium miners, 1970–2003
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371580/
https://www.ncbi.nlm.nih.gov/pubmed/22685223
http://dx.doi.org/10.1136/bmjopen-2012-001002
work_keys_str_mv AT walshlinda prostatecancermortalityriskinrelationtoworkingundergroundinthewismutcohortstudyofgermanuraniumminers19702003
AT dufeyflorian prostatecancermortalityriskinrelationtoworkingundergroundinthewismutcohortstudyofgermanuraniumminers19702003
AT tschenseannemarie prostatecancermortalityriskinrelationtoworkingundergroundinthewismutcohortstudyofgermanuraniumminers19702003
AT schnelzermaria prostatecancermortalityriskinrelationtoworkingundergroundinthewismutcohortstudyofgermanuraniumminers19702003
AT soglmarion prostatecancermortalityriskinrelationtoworkingundergroundinthewismutcohortstudyofgermanuraniumminers19702003
AT kreuzermichaela prostatecancermortalityriskinrelationtoworkingundergroundinthewismutcohortstudyofgermanuraniumminers19702003