Cargando…

siRNA Design Software for a Target Gene-Specific RNA Interference

RNA interference (RNAi) is a mechanism through which small interfering RNA (siRNA) induces sequence-specific posttranscriptional gene silencing. RNAi is commonly recognized as a powerful tool not only for functional genomics but also for therapeutic applications. Twenty-one-nucleotide-long siRNA sup...

Descripción completa

Detalles Bibliográficos
Autores principales:	Naito, Yuki, Ui-Tei, Kumiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371628/ https://www.ncbi.nlm.nih.gov/pubmed/22701467 http://dx.doi.org/10.3389/fgene.2012.00102

Ejemplares similares

siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect
por: Naito, Yuki, et al.
Publicado: (2009)

siVirus: web-based antiviral siRNA design software for highly divergent viral sequences
por: Naito, Yuki, et al.
Publicado: (2006)

Optimal design and validation of antiviral siRNA for targeting HIV-1
por: Naito, Yuki, et al.
Publicado: (2007)

Optimal choice of functional and off-target effect-reduced siRNAs for RNAi therapeutics
por: Ui-Tei, Kumiko
Publicado: (2013)

Essential Notes Regarding the Design of Functional siRNAs for Efficient Mammalian RNAi
por: Ui-Tei, Kumiko, et al.
Publicado: (2006)

dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference
por: Naito, Yuki, et al.
Publicado: (2005)

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect
por: Ui-Tei, Kumiko, et al.
Publicado: (2008)

CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites
por: Naito, Yuki, et al.
Publicado: (2015)

Thermodynamic stability and Watson–Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect
por: Ui-Tei, Kumiko, et al.
Publicado: (2008)

siRNA Seed Region Is Divided into Two Functionally Different Domains in RNA Interference in Response to 2′-OMe Modifications
por: Kobayashi, Yoshiaki, et al.
Publicado: (2022)

The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects
por: Kobayashi, Yoshiaki, et al.
Publicado: (2022)

The siRNA Non-seed Region and Its Target Sequences Are Auxiliary Determinants of Off-Target Effects
por: Kamola, Piotr J., et al.
Publicado: (2015)

Thermodynamic Control of Small RNA-Mediated Gene Silencing
por: Ui-Tei, Kumiko, et al.
Publicado: (2012)

Distinguishable In Vitro Binding Mode of Monomeric TRBP and Dimeric PACT with siRNA
por: Takahashi, Tomoko, et al.
Publicado: (2013)

Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets
por: Iribe, Hanna, et al.
Publicado: (2017)

Correction to “Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets”
por: Iribe, Hanna, et al.
Publicado: (2017)

Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells
por: Takahashi, Tomoko, et al.
Publicado: (2014)

siRNA-Finder (si-Fi) Software for RNAi-Target Design and Off-Target Prediction
por: Lück, Stefanie, et al.
Publicado: (2019)

siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference
por: Fang, Zhiming, et al.
Publicado: (2021)

Generation of siRNA Nanosheets for Efficient RNA Interference
por: Kim, Hyejin, et al.
Publicado: (2016)

E-Cadherin Is Transcriptionally Activated via Suppression of ZEB1 Transcriptional Repressor by Small RNA-Mediated Gene Silencing
por: Mazda, Minami, et al.
Publicado: (2011)

Cell-specific RNA interference by peptide-inhibited-peptidase-activated siRNAs
por: Koehn, Sandra, et al.
Publicado: (2010)

Gene silencing of HPV16 E6/E7 induced by promoter-targeting siRNA in SiHa cells
por: Hong, D, et al.
Publicado: (2009)

RNA Secondary Structure Motifs of the Influenza A Virus as Targets for siRNA-Mediated RNA Interference
por: Piasecka, Julita, et al.
Publicado: (2019)

Minimizing off-target effects by using diced siRNAs for RNA interference
por: Myers, Jason W, et al.
Publicado: (2006)

Targeted Delivery of siRNA
por: Oliveira, Sabrina, et al.
Publicado: (2006)

RNAi-mediated knockdown of mouse melanocortin-4 receptor in vitro and in vivo, using an siRNA expression construct based on the mir-187 precursor
por: Kato, Minoru, et al.
Publicado: (2016)

Off-target effects of siRNA specific for GFP
por: Tschuch, Cordula, et al.
Publicado: (2008)

Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry
por: Wang, Peipei, et al.
Publicado: (2021)

Advances in Targeting Cancer-Associated Genes by Designed siRNA in Prostate Cancer
por: Bahreyni, Amirhossein, et al.
Publicado: (2020)

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates
por: Foster, Donald J., et al.
Publicado: (2018)

In Silico Target-Specific siRNA Design Based on Domain Transfer in Heterogeneous Data
por: Liu, Qi, et al.
Publicado: (2012)

sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database
por: Shah, Jyoti K, et al.
Publicado: (2007)

Rational design of microRNA–siRNA chimeras for multifunctional target suppression
por: Jiang, Zhou, et al.
Publicado: (2013)

RORC2 Gene Silencing in Human Th17 Cells by siRNA: Design and Evaluation of Highly Efficient siRNA
por: Hakemi, Mazdak Ganjalikhani, et al.
Publicado: (2013)

Is the Efficiency of RNA Silencing Evolutionarily Regulated?
por: Ui-Tei, Kumiko
Publicado: (2016)

Analysis of siRNA specificity on targets with double-nucleotide mismatches
por: Dahlgren, Cecilia, et al.
Publicado: (2008)

Applications of RNA interference: current state and prospects for siRNA-based strategies in vivo
por: Aigner, Achim
Publicado: (2007)

MysiRNA-Designer: A Workflow for Efficient siRNA Design
por: Mysara, Mohamed, et al.
Publicado: (2011)

Bone site-specific delivery of siRNA
por: Liu, Xinli
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nb7p9lm5hq9ole1b79uslfpmju