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Stem Cell Niches for Skin Regeneration

Stem cell-based therapies offer tremendous potential for skin regeneration following injury and disease. Functional stem cell units have been described throughout all layers of human skin and the collective physical and chemical microenvironmental cues that enable this regenerative potential are kno...

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Detalles Bibliográficos
Autores principales: Wong, Victor W., Levi, Benjamin, Rajadas, Jayakumar, Longaker, Michael T., Gurtner, Geoffrey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371691/
https://www.ncbi.nlm.nih.gov/pubmed/22701121
http://dx.doi.org/10.1155/2012/926059
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author Wong, Victor W.
Levi, Benjamin
Rajadas, Jayakumar
Longaker, Michael T.
Gurtner, Geoffrey C.
author_facet Wong, Victor W.
Levi, Benjamin
Rajadas, Jayakumar
Longaker, Michael T.
Gurtner, Geoffrey C.
author_sort Wong, Victor W.
collection PubMed
description Stem cell-based therapies offer tremendous potential for skin regeneration following injury and disease. Functional stem cell units have been described throughout all layers of human skin and the collective physical and chemical microenvironmental cues that enable this regenerative potential are known as the stem cell niche. Stem cells in the hair follicle bulge, interfollicular epidermis, dermal papillae, and perivascular space have been closely investigated as model systems for niche-driven regeneration. These studies suggest that stem cell strategies for skin engineering must consider the intricate molecular and biologic features of these niches. Innovative biomaterial systems that successfully recapitulate these microenvironments will facilitate progenitor cell-mediated skin repair and regeneration.
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spelling pubmed-33716912012-06-13 Stem Cell Niches for Skin Regeneration Wong, Victor W. Levi, Benjamin Rajadas, Jayakumar Longaker, Michael T. Gurtner, Geoffrey C. Int J Biomater Review Article Stem cell-based therapies offer tremendous potential for skin regeneration following injury and disease. Functional stem cell units have been described throughout all layers of human skin and the collective physical and chemical microenvironmental cues that enable this regenerative potential are known as the stem cell niche. Stem cells in the hair follicle bulge, interfollicular epidermis, dermal papillae, and perivascular space have been closely investigated as model systems for niche-driven regeneration. These studies suggest that stem cell strategies for skin engineering must consider the intricate molecular and biologic features of these niches. Innovative biomaterial systems that successfully recapitulate these microenvironments will facilitate progenitor cell-mediated skin repair and regeneration. Hindawi Publishing Corporation 2012 2012-06-03 /pmc/articles/PMC3371691/ /pubmed/22701121 http://dx.doi.org/10.1155/2012/926059 Text en Copyright © 2012 Victor W. Wong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wong, Victor W.
Levi, Benjamin
Rajadas, Jayakumar
Longaker, Michael T.
Gurtner, Geoffrey C.
Stem Cell Niches for Skin Regeneration
title Stem Cell Niches for Skin Regeneration
title_full Stem Cell Niches for Skin Regeneration
title_fullStr Stem Cell Niches for Skin Regeneration
title_full_unstemmed Stem Cell Niches for Skin Regeneration
title_short Stem Cell Niches for Skin Regeneration
title_sort stem cell niches for skin regeneration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371691/
https://www.ncbi.nlm.nih.gov/pubmed/22701121
http://dx.doi.org/10.1155/2012/926059
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