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Stem Cell Niches for Skin Regeneration
Stem cell-based therapies offer tremendous potential for skin regeneration following injury and disease. Functional stem cell units have been described throughout all layers of human skin and the collective physical and chemical microenvironmental cues that enable this regenerative potential are kno...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371691/ https://www.ncbi.nlm.nih.gov/pubmed/22701121 http://dx.doi.org/10.1155/2012/926059 |
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author | Wong, Victor W. Levi, Benjamin Rajadas, Jayakumar Longaker, Michael T. Gurtner, Geoffrey C. |
author_facet | Wong, Victor W. Levi, Benjamin Rajadas, Jayakumar Longaker, Michael T. Gurtner, Geoffrey C. |
author_sort | Wong, Victor W. |
collection | PubMed |
description | Stem cell-based therapies offer tremendous potential for skin regeneration following injury and disease. Functional stem cell units have been described throughout all layers of human skin and the collective physical and chemical microenvironmental cues that enable this regenerative potential are known as the stem cell niche. Stem cells in the hair follicle bulge, interfollicular epidermis, dermal papillae, and perivascular space have been closely investigated as model systems for niche-driven regeneration. These studies suggest that stem cell strategies for skin engineering must consider the intricate molecular and biologic features of these niches. Innovative biomaterial systems that successfully recapitulate these microenvironments will facilitate progenitor cell-mediated skin repair and regeneration. |
format | Online Article Text |
id | pubmed-3371691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33716912012-06-13 Stem Cell Niches for Skin Regeneration Wong, Victor W. Levi, Benjamin Rajadas, Jayakumar Longaker, Michael T. Gurtner, Geoffrey C. Int J Biomater Review Article Stem cell-based therapies offer tremendous potential for skin regeneration following injury and disease. Functional stem cell units have been described throughout all layers of human skin and the collective physical and chemical microenvironmental cues that enable this regenerative potential are known as the stem cell niche. Stem cells in the hair follicle bulge, interfollicular epidermis, dermal papillae, and perivascular space have been closely investigated as model systems for niche-driven regeneration. These studies suggest that stem cell strategies for skin engineering must consider the intricate molecular and biologic features of these niches. Innovative biomaterial systems that successfully recapitulate these microenvironments will facilitate progenitor cell-mediated skin repair and regeneration. Hindawi Publishing Corporation 2012 2012-06-03 /pmc/articles/PMC3371691/ /pubmed/22701121 http://dx.doi.org/10.1155/2012/926059 Text en Copyright © 2012 Victor W. Wong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wong, Victor W. Levi, Benjamin Rajadas, Jayakumar Longaker, Michael T. Gurtner, Geoffrey C. Stem Cell Niches for Skin Regeneration |
title | Stem Cell Niches for Skin Regeneration |
title_full | Stem Cell Niches for Skin Regeneration |
title_fullStr | Stem Cell Niches for Skin Regeneration |
title_full_unstemmed | Stem Cell Niches for Skin Regeneration |
title_short | Stem Cell Niches for Skin Regeneration |
title_sort | stem cell niches for skin regeneration |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371691/ https://www.ncbi.nlm.nih.gov/pubmed/22701121 http://dx.doi.org/10.1155/2012/926059 |
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