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Exploring Short-Term Responses to Changes in the Control Strategy for Chlamydia trachomatis

Chlamydia has a significant impact on public health provision in the developed world. Using pair approximation equations we investigate the efficacy of control programmes for chlamydia on short time scales that are relevant to policy makers. We use output from the model to estimate critical measures...

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Detalles Bibliográficos
Autores principales: Clarke, James, White, K. A. Jane, Turner, Katy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371724/
https://www.ncbi.nlm.nih.gov/pubmed/22701143
http://dx.doi.org/10.1155/2012/803097
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author Clarke, James
White, K. A. Jane
Turner, Katy
author_facet Clarke, James
White, K. A. Jane
Turner, Katy
author_sort Clarke, James
collection PubMed
description Chlamydia has a significant impact on public health provision in the developed world. Using pair approximation equations we investigate the efficacy of control programmes for chlamydia on short time scales that are relevant to policy makers. We use output from the model to estimate critical measures, namely, prevalence, incidence, and positivity in those screened and their partners. We combine these measures with a costing tool to estimate the economic impact of different public health strategies. Increasing screening coverage significantly increases the annual programme costs whereas an increase in tracing efficiency initially increases annual costs but over time reduces costs below baseline, with tracing accounting for around 10% of intervention costs. We found that partner positivity is insensitive to changes in prevalence due to screening, remaining at around 33%. Whether increases occur in screening or tracing levels, the cost per treated infection increases from the baseline because of reduced prevalence.
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spelling pubmed-33717242012-06-13 Exploring Short-Term Responses to Changes in the Control Strategy for Chlamydia trachomatis Clarke, James White, K. A. Jane Turner, Katy Comput Math Methods Med Research Article Chlamydia has a significant impact on public health provision in the developed world. Using pair approximation equations we investigate the efficacy of control programmes for chlamydia on short time scales that are relevant to policy makers. We use output from the model to estimate critical measures, namely, prevalence, incidence, and positivity in those screened and their partners. We combine these measures with a costing tool to estimate the economic impact of different public health strategies. Increasing screening coverage significantly increases the annual programme costs whereas an increase in tracing efficiency initially increases annual costs but over time reduces costs below baseline, with tracing accounting for around 10% of intervention costs. We found that partner positivity is insensitive to changes in prevalence due to screening, remaining at around 33%. Whether increases occur in screening or tracing levels, the cost per treated infection increases from the baseline because of reduced prevalence. Hindawi Publishing Corporation 2012 2012-06-03 /pmc/articles/PMC3371724/ /pubmed/22701143 http://dx.doi.org/10.1155/2012/803097 Text en Copyright © 2012 James Clarke et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Clarke, James
White, K. A. Jane
Turner, Katy
Exploring Short-Term Responses to Changes in the Control Strategy for Chlamydia trachomatis
title Exploring Short-Term Responses to Changes in the Control Strategy for Chlamydia trachomatis
title_full Exploring Short-Term Responses to Changes in the Control Strategy for Chlamydia trachomatis
title_fullStr Exploring Short-Term Responses to Changes in the Control Strategy for Chlamydia trachomatis
title_full_unstemmed Exploring Short-Term Responses to Changes in the Control Strategy for Chlamydia trachomatis
title_short Exploring Short-Term Responses to Changes in the Control Strategy for Chlamydia trachomatis
title_sort exploring short-term responses to changes in the control strategy for chlamydia trachomatis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371724/
https://www.ncbi.nlm.nih.gov/pubmed/22701143
http://dx.doi.org/10.1155/2012/803097
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