Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation

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ADAM17 (a disintegrin and metalloproteinase 17) is ubiquitously expressed and cleaves membrane proteins, such as epidermal growth factor receptor (EGFR) ligands, l-selectin, and TNF, from the cell surface, thus regulating responses to tissue injury and inflammation. However, little is currently know...

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Detalles Bibliográficos
Autores principales: Franzke, Claus-Werner, Cobzaru, Cristina, Triantafyllopoulou, Antigoni, Löffek, Stefanie, Horiuchi, Keisuke, Threadgill, David W., Kurz, Thomas, van Rooijen, Nico, Bruckner-Tuderman, Leena, Blobel, Carl P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371728/
https://www.ncbi.nlm.nih.gov/pubmed/22565824
http://dx.doi.org/10.1084/jem.20112258
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