Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise from hematopoietic precursors that seed the skin before birth. However, the origin of these embryonic precursors...

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Detalles Bibliográficos
Autores principales: Hoeffel, Guillaume, Wang, Yilin, Greter, Melanie, See, Peter, Teo, Pearline, Malleret, Benoit, Leboeuf, Marylène, Low, Donovan, Oller, Guillaume, Almeida, Francisca, Choy, Sharon H.Y., Grisotto, Marcos, Renia, Laurent, Conway, Simon J., Stanley, E. Richard, Chan, Jerry K.Y., Ng, Lai Guan, Samokhvalov, Igor M., Merad, Miriam, Ginhoux, Florent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371735/
https://www.ncbi.nlm.nih.gov/pubmed/22565823
http://dx.doi.org/10.1084/jem.20120340

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