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Potential Impact of Antiviral Drug Use during Influenza Pandemic
The recent spread of highly pathogenic strains of avian influenza has highlighted the threat posed by pandemic influenza. In the early phases of a pandemic, the only treatment available would be neuraminidase inhibitors, which many countries are considering stockpiling for pandemic use. We estimate...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371825/ https://www.ncbi.nlm.nih.gov/pubmed/16229762 http://dx.doi.org/10.3201/eid1109.041344 |
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author | Gani, Raymond Hughes, Helen Fleming, Douglas Griffin, Thomas Medlock, Jolyon Leach, Steve |
author_facet | Gani, Raymond Hughes, Helen Fleming, Douglas Griffin, Thomas Medlock, Jolyon Leach, Steve |
author_sort | Gani, Raymond |
collection | PubMed |
description | The recent spread of highly pathogenic strains of avian influenza has highlighted the threat posed by pandemic influenza. In the early phases of a pandemic, the only treatment available would be neuraminidase inhibitors, which many countries are considering stockpiling for pandemic use. We estimate the effect on hospitalization rates of using different antiviral stockpile sizes to treat infection. We estimate that stockpiles that cover 20%–25% of the population would be sufficient to treat most of the clinical cases and could lead to 50% to 77% reductions in hospitalizations. Substantial reductions in hospitalization could be achieved with smaller antiviral stockpiles if drugs are reserved for persons at high risk. |
format | Online Article Text |
id | pubmed-3371825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-33718252012-06-21 Potential Impact of Antiviral Drug Use during Influenza Pandemic Gani, Raymond Hughes, Helen Fleming, Douglas Griffin, Thomas Medlock, Jolyon Leach, Steve Emerg Infect Dis Research The recent spread of highly pathogenic strains of avian influenza has highlighted the threat posed by pandemic influenza. In the early phases of a pandemic, the only treatment available would be neuraminidase inhibitors, which many countries are considering stockpiling for pandemic use. We estimate the effect on hospitalization rates of using different antiviral stockpile sizes to treat infection. We estimate that stockpiles that cover 20%–25% of the population would be sufficient to treat most of the clinical cases and could lead to 50% to 77% reductions in hospitalizations. Substantial reductions in hospitalization could be achieved with smaller antiviral stockpiles if drugs are reserved for persons at high risk. Centers for Disease Control and Prevention 2005-09 /pmc/articles/PMC3371825/ /pubmed/16229762 http://dx.doi.org/10.3201/eid1109.041344 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Gani, Raymond Hughes, Helen Fleming, Douglas Griffin, Thomas Medlock, Jolyon Leach, Steve Potential Impact of Antiviral Drug Use during Influenza Pandemic |
title | Potential Impact of Antiviral Drug Use during Influenza Pandemic |
title_full | Potential Impact of Antiviral Drug Use during Influenza Pandemic |
title_fullStr | Potential Impact of Antiviral Drug Use during Influenza Pandemic |
title_full_unstemmed | Potential Impact of Antiviral Drug Use during Influenza Pandemic |
title_short | Potential Impact of Antiviral Drug Use during Influenza Pandemic |
title_sort | potential impact of antiviral drug use during influenza pandemic |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371825/ https://www.ncbi.nlm.nih.gov/pubmed/16229762 http://dx.doi.org/10.3201/eid1109.041344 |
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