Tachyon search speeds up retrieval of similar sequences by several orders of magnitude

Summary: The usage of current sequence search tools becomes increasingly slower as databases of protein sequences continue to grow exponentially. Tachyon, a new algorithm that identifies closely related protein sequences ~200 times faster than standard BLAST, circumvents this limitation with a reduc...

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Detalles Bibliográficos
Autores principales: Tan, Joshua, Kuchibhatla, Durga, Sirota, Fernanda L., Sherman, Westley A., Gattermayer, Tobias, Kwoh, Chia Yee, Eisenhaber, Frank, Schneider, Georg, Maurer-Stroh, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Applications Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371831/
https://www.ncbi.nlm.nih.gov/pubmed/22531216
http://dx.doi.org/10.1093/bioinformatics/bts197
Descripción
Sumario:Summary: The usage of current sequence search tools becomes increasingly slower as databases of protein sequences continue to grow exponentially. Tachyon, a new algorithm that identifies closely related protein sequences ~200 times faster than standard BLAST, circumvents this limitation with a reduced database and oligopeptide matching heuristic. Availability and implementation: The tool is publicly accessible as a webserver at http://tachyon.bii.a-star.edu.sg and can also be accessed programmatically through SOAP. Contact: sebastianms@bii.a-star.edu.sg Supplementary information: Supplementary data are available at the Bioinformatics online.

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