The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in Rat

BACKGROUND: Reports on agmatine are controversial showing that it may improve memory, it can deteriorate memory and some did not notice any interference with learning and memory. In the present study, the effect of directly intra-CA1 agmatine microinjection on water maze learning and memory has been...

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Detalles Bibliográficos
Autores principales: Rastegar, K, Roosta, H, Zarifkar, A, Rafati, A, Moosavi, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371968/
https://www.ncbi.nlm.nih.gov/pubmed/22737487
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author Rastegar, K
Roosta, H
Zarifkar, A
Rafati, A
Moosavi, M
author_facet Rastegar, K
Roosta, H
Zarifkar, A
Rafati, A
Moosavi, M
author_sort Rastegar, K
collection PubMed
description BACKGROUND: Reports on agmatine are controversial showing that it may improve memory, it can deteriorate memory and some did not notice any interference with learning and memory. In the present study, the effect of directly intra-CA1 agmatine microinjection on water maze learning and memory has been assessed. METHODS: The cannuls were implanted in hippocampal CA1 regions of rats in a sterotaxic frame after general anesthesia. After one week recovery period, the animals were assessed in the reference memory version of water maze. Agmatine (1, 10, 100 or 200 μg/0.5 μl) or saline were infused 20 minutes before or immediately after training. RESULTS: Agmatine-treated rats did not show any significant difference neither in water maze acquisition nor in consolidation task in comparison with control and sham groups. CONCLUSION: Agmatine does not affect water maze learning and memory.
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spelling pubmed-33719682012-06-21 The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in Rat Rastegar, K Roosta, H Zarifkar, A Rafati, A Moosavi, M Iran Red Crescent Med J Original Article BACKGROUND: Reports on agmatine are controversial showing that it may improve memory, it can deteriorate memory and some did not notice any interference with learning and memory. In the present study, the effect of directly intra-CA1 agmatine microinjection on water maze learning and memory has been assessed. METHODS: The cannuls were implanted in hippocampal CA1 regions of rats in a sterotaxic frame after general anesthesia. After one week recovery period, the animals were assessed in the reference memory version of water maze. Agmatine (1, 10, 100 or 200 μg/0.5 μl) or saline were infused 20 minutes before or immediately after training. RESULTS: Agmatine-treated rats did not show any significant difference neither in water maze acquisition nor in consolidation task in comparison with control and sham groups. CONCLUSION: Agmatine does not affect water maze learning and memory. Kowsar 2011-05 2011-05-01 /pmc/articles/PMC3371968/ /pubmed/22737487 Text en Copyright © 2011, Kowsar M.P. Co. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Rastegar, K
Roosta, H
Zarifkar, A
Rafati, A
Moosavi, M
The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in Rat
title The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in Rat
title_full The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in Rat
title_fullStr The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in Rat
title_full_unstemmed The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in Rat
title_short The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in Rat
title_sort effect of intra-ca1 agmatine microinjection on water maze learning and memory in rat
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371968/
https://www.ncbi.nlm.nih.gov/pubmed/22737487
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