The Healing Effect of Arnebia Euchroma in Second Degree Burn Wounds in Rat as an Animal Model

BACKGROUND: Finding more efficient agents with fewer side effects for treatment of burns has always been a concern for researchers. Silver sulfadiazine (SSD), apparently due to its antimicrobial effect, is still one of the most common prescribed agents. Previous studies suggested that Arnebia euchro...

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Autores principales: Ashkani-Esfahani, S, Imanieh, M H, Khoshneviszadeh, M, Meshksar, A, Noorafshan, A, Geramizadeh, B, Ebrahimi, S, Handjani, F, Tanideh, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372044/
https://www.ncbi.nlm.nih.gov/pubmed/22737558
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author Ashkani-Esfahani, S
Imanieh, M H
Khoshneviszadeh, M
Meshksar, A
Noorafshan, A
Geramizadeh, B
Ebrahimi, S
Handjani, F
Tanideh, N
author_facet Ashkani-Esfahani, S
Imanieh, M H
Khoshneviszadeh, M
Meshksar, A
Noorafshan, A
Geramizadeh, B
Ebrahimi, S
Handjani, F
Tanideh, N
author_sort Ashkani-Esfahani, S
collection PubMed
description BACKGROUND: Finding more efficient agents with fewer side effects for treatment of burns has always been a concern for researchers. Silver sulfadiazine (SSD), apparently due to its antimicrobial effect, is still one of the most common prescribed agents. Previous studies suggested that Arnebia euchroma (AE) has shown antimicrobial and anti-inflammatory activities. This study investigates the healing effect of AE extract in comparison with SSD in second degree burn wounds. METHODS: Fort eight female Wistar rats (220±20 g) were divided into four groups. Standard second degree burn wounds were induced on the back of their necks. One group was treated with SSD; two groups were treated with AE cream at concentrations of 10% (AE10) and 20% (AE20) and the control group which received no treatment. The duration of treatment was 28 days. RESULTS: This study revealed that AE and SSD noticeably improved re-epithelization, fibroblasts proliferation, and collagen bundle synthesis and had a noticeable anti-inflammatory effect compared with the control group. CONCLUSION: Results of the present study revealed that Arnebia euchroma herbal extract was an effective treatment for second degree burn wounds when compared with SSD.
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spelling pubmed-33720442012-06-21 The Healing Effect of Arnebia Euchroma in Second Degree Burn Wounds in Rat as an Animal Model Ashkani-Esfahani, S Imanieh, M H Khoshneviszadeh, M Meshksar, A Noorafshan, A Geramizadeh, B Ebrahimi, S Handjani, F Tanideh, N Iran Red Crescent Med J Original Article BACKGROUND: Finding more efficient agents with fewer side effects for treatment of burns has always been a concern for researchers. Silver sulfadiazine (SSD), apparently due to its antimicrobial effect, is still one of the most common prescribed agents. Previous studies suggested that Arnebia euchroma (AE) has shown antimicrobial and anti-inflammatory activities. This study investigates the healing effect of AE extract in comparison with SSD in second degree burn wounds. METHODS: Fort eight female Wistar rats (220±20 g) were divided into four groups. Standard second degree burn wounds were induced on the back of their necks. One group was treated with SSD; two groups were treated with AE cream at concentrations of 10% (AE10) and 20% (AE20) and the control group which received no treatment. The duration of treatment was 28 days. RESULTS: This study revealed that AE and SSD noticeably improved re-epithelization, fibroblasts proliferation, and collagen bundle synthesis and had a noticeable anti-inflammatory effect compared with the control group. CONCLUSION: Results of the present study revealed that Arnebia euchroma herbal extract was an effective treatment for second degree burn wounds when compared with SSD. Kowsar 2012-02 2012-02-01 /pmc/articles/PMC3372044/ /pubmed/22737558 Text en Copyright © 2012, Kowsar Corp. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ashkani-Esfahani, S
Imanieh, M H
Khoshneviszadeh, M
Meshksar, A
Noorafshan, A
Geramizadeh, B
Ebrahimi, S
Handjani, F
Tanideh, N
The Healing Effect of Arnebia Euchroma in Second Degree Burn Wounds in Rat as an Animal Model
title The Healing Effect of Arnebia Euchroma in Second Degree Burn Wounds in Rat as an Animal Model
title_full The Healing Effect of Arnebia Euchroma in Second Degree Burn Wounds in Rat as an Animal Model
title_fullStr The Healing Effect of Arnebia Euchroma in Second Degree Burn Wounds in Rat as an Animal Model
title_full_unstemmed The Healing Effect of Arnebia Euchroma in Second Degree Burn Wounds in Rat as an Animal Model
title_short The Healing Effect of Arnebia Euchroma in Second Degree Burn Wounds in Rat as an Animal Model
title_sort healing effect of arnebia euchroma in second degree burn wounds in rat as an animal model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372044/
https://www.ncbi.nlm.nih.gov/pubmed/22737558
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