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Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus

Ficus deltoidea from the Moraceae family has been scientifically proven to reduce hyperglycemia at different prandial states. In this study, we evaluate the mechanisms that underlie antihyperglycemic action of Ficus deltoidea. The results had shown that hot aqueous extract of Ficus deltoidea stimula...

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Detalles Bibliográficos
Autores principales: Adam, Zainah, Khamis, Shafii, Ismail, Amin, Hamid, Muhajir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372277/
https://www.ncbi.nlm.nih.gov/pubmed/22701507
http://dx.doi.org/10.1155/2012/632763
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author Adam, Zainah
Khamis, Shafii
Ismail, Amin
Hamid, Muhajir
author_facet Adam, Zainah
Khamis, Shafii
Ismail, Amin
Hamid, Muhajir
author_sort Adam, Zainah
collection PubMed
description Ficus deltoidea from the Moraceae family has been scientifically proven to reduce hyperglycemia at different prandial states. In this study, we evaluate the mechanisms that underlie antihyperglycemic action of Ficus deltoidea. The results had shown that hot aqueous extract of Ficus deltoidea stimulated insulin secretion significantly with the highest magnitude of stimulation was 7.31-fold (P < 0.001). The insulin secretory actions of the hot aqueous extract involved K(+)  (ATP) channel-dependent and K(+)  (ATP)-channel-independent pathway. The extract also has the ability to induce the usage of intracellular Ca(2+) to trigger insulin release. The ethanolic and methanolic extracts enhanced basal and insulin-mediated glucose uptake into adipocytes cells. The extracts possess either insulin-mimetic or insulin-sensitizing property or combination of both properties during enhancing glucose uptake into such cells. Meanwhile, the hot aqueous and methanolic extracts augmented basal and insulin-stimulated adiponectin secretion from adipocytes cells. From this study, it is suggested that Ficus deltoidea has the potential to be developed as future oral antidiabetic agent.
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spelling pubmed-33722772012-06-13 Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus Adam, Zainah Khamis, Shafii Ismail, Amin Hamid, Muhajir Evid Based Complement Alternat Med Research Article Ficus deltoidea from the Moraceae family has been scientifically proven to reduce hyperglycemia at different prandial states. In this study, we evaluate the mechanisms that underlie antihyperglycemic action of Ficus deltoidea. The results had shown that hot aqueous extract of Ficus deltoidea stimulated insulin secretion significantly with the highest magnitude of stimulation was 7.31-fold (P < 0.001). The insulin secretory actions of the hot aqueous extract involved K(+)  (ATP) channel-dependent and K(+)  (ATP)-channel-independent pathway. The extract also has the ability to induce the usage of intracellular Ca(2+) to trigger insulin release. The ethanolic and methanolic extracts enhanced basal and insulin-mediated glucose uptake into adipocytes cells. The extracts possess either insulin-mimetic or insulin-sensitizing property or combination of both properties during enhancing glucose uptake into such cells. Meanwhile, the hot aqueous and methanolic extracts augmented basal and insulin-stimulated adiponectin secretion from adipocytes cells. From this study, it is suggested that Ficus deltoidea has the potential to be developed as future oral antidiabetic agent. Hindawi Publishing Corporation 2012 2012-06-03 /pmc/articles/PMC3372277/ /pubmed/22701507 http://dx.doi.org/10.1155/2012/632763 Text en Copyright © 2012 Zainah Adam et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Adam, Zainah
Khamis, Shafii
Ismail, Amin
Hamid, Muhajir
Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus
title Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus
title_full Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus
title_fullStr Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus
title_full_unstemmed Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus
title_short Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus
title_sort ficus deltoidea: a potential alternative medicine for diabetes mellitus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372277/
https://www.ncbi.nlm.nih.gov/pubmed/22701507
http://dx.doi.org/10.1155/2012/632763
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