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Seroprevalence of Hepatitis E Virus Infection, Rural Southern People’s Republic of China

Genotype 4 hepatitis E virus (HEV) is the dominant cause of hepatitis E in the People's Republic of China; swine are the principal reservoir. Our study was conducted in 8 rural communities of southern China, where families keep pigs near their homes. Phylogenetic analysis showed that 23 of 24 c...

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Autores principales: Li, Rong-Cheng, Ge, Sheng-Xiang, Li, Yan-Ping, Zheng, Ying-Jie, Nong, Yi, Guo, Qing-Shun, Zhang, Jun, Ng, Mun-Hon, Xia, Ning-Shao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372335/
https://www.ncbi.nlm.nih.gov/pubmed/17283617
http://dx.doi.org/10.3201/eid1211.060332
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author Li, Rong-Cheng
Ge, Sheng-Xiang
Li, Yan-Ping
Zheng, Ying-Jie
Nong, Yi
Guo, Qing-Shun
Zhang, Jun
Ng, Mun-Hon
Xia, Ning-Shao
author_facet Li, Rong-Cheng
Ge, Sheng-Xiang
Li, Yan-Ping
Zheng, Ying-Jie
Nong, Yi
Guo, Qing-Shun
Zhang, Jun
Ng, Mun-Hon
Xia, Ning-Shao
author_sort Li, Rong-Cheng
collection PubMed
description Genotype 4 hepatitis E virus (HEV) is the dominant cause of hepatitis E in the People's Republic of China; swine are the principal reservoir. Our study was conducted in 8 rural communities of southern China, where families keep pigs near their homes. Phylogenetic analysis showed that 23 of 24 concurrent virus isolates from this region are genotype 4 strains. Among the study populations, immunoglobulin G anti-HEV seroprevalence accumulated with age at ≈1% per year for persons >60 years of age. After age 30 years, seroprevalence increased at higher rates for male than for female study participants. The overall seroprevalence was 43% (range 25%–66%) among the communities. Infection rates were higher for participants between 25 and 29 years of age. The results suggest that HEV infection probably has been endemic in southern China for <60 years, with swine being the principal reservoir of human HEV infection in recent years.
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spelling pubmed-33723352012-06-21 Seroprevalence of Hepatitis E Virus Infection, Rural Southern People’s Republic of China Li, Rong-Cheng Ge, Sheng-Xiang Li, Yan-Ping Zheng, Ying-Jie Nong, Yi Guo, Qing-Shun Zhang, Jun Ng, Mun-Hon Xia, Ning-Shao Emerg Infect Dis Research Genotype 4 hepatitis E virus (HEV) is the dominant cause of hepatitis E in the People's Republic of China; swine are the principal reservoir. Our study was conducted in 8 rural communities of southern China, where families keep pigs near their homes. Phylogenetic analysis showed that 23 of 24 concurrent virus isolates from this region are genotype 4 strains. Among the study populations, immunoglobulin G anti-HEV seroprevalence accumulated with age at ≈1% per year for persons >60 years of age. After age 30 years, seroprevalence increased at higher rates for male than for female study participants. The overall seroprevalence was 43% (range 25%–66%) among the communities. Infection rates were higher for participants between 25 and 29 years of age. The results suggest that HEV infection probably has been endemic in southern China for <60 years, with swine being the principal reservoir of human HEV infection in recent years. Centers for Disease Control and Prevention 2006-11 /pmc/articles/PMC3372335/ /pubmed/17283617 http://dx.doi.org/10.3201/eid1211.060332 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Li, Rong-Cheng
Ge, Sheng-Xiang
Li, Yan-Ping
Zheng, Ying-Jie
Nong, Yi
Guo, Qing-Shun
Zhang, Jun
Ng, Mun-Hon
Xia, Ning-Shao
Seroprevalence of Hepatitis E Virus Infection, Rural Southern People’s Republic of China
title Seroprevalence of Hepatitis E Virus Infection, Rural Southern People’s Republic of China
title_full Seroprevalence of Hepatitis E Virus Infection, Rural Southern People’s Republic of China
title_fullStr Seroprevalence of Hepatitis E Virus Infection, Rural Southern People’s Republic of China
title_full_unstemmed Seroprevalence of Hepatitis E Virus Infection, Rural Southern People’s Republic of China
title_short Seroprevalence of Hepatitis E Virus Infection, Rural Southern People’s Republic of China
title_sort seroprevalence of hepatitis e virus infection, rural southern people’s republic of china
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372335/
https://www.ncbi.nlm.nih.gov/pubmed/17283617
http://dx.doi.org/10.3201/eid1211.060332
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