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No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patients

Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility....

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Autores principales: Kim, Il-Soo, Yoon, Ho-Kyoung, Kang, Seung-Gul, Park, Young-Min, Kim, Yong-Ku, Kim, Seung-Hyun, Choi, Jung-Eun, Kim, Leen, Lee, Heon-Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372569/
https://www.ncbi.nlm.nih.gov/pubmed/22707972
http://dx.doi.org/10.4306/pi.2012.9.2.191
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author Kim, Il-Soo
Yoon, Ho-Kyoung
Kang, Seung-Gul
Park, Young-Min
Kim, Yong-Ku
Kim, Seung-Hyun
Choi, Jung-Eun
Kim, Leen
Lee, Heon-Jeong
author_facet Kim, Il-Soo
Yoon, Ho-Kyoung
Kang, Seung-Gul
Park, Young-Min
Kim, Yong-Ku
Kim, Seung-Hyun
Choi, Jung-Eun
Kim, Leen
Lee, Heon-Jeong
author_sort Kim, Il-Soo
collection PubMed
description Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Three single nucleotide polymorphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. There were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD.
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spelling pubmed-33725692012-06-15 No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patients Kim, Il-Soo Yoon, Ho-Kyoung Kang, Seung-Gul Park, Young-Min Kim, Yong-Ku Kim, Seung-Hyun Choi, Jung-Eun Kim, Leen Lee, Heon-Jeong Psychiatry Investig Brief Report Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Three single nucleotide polymorphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. There were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD. Korean Neuropsychiatric Association 2012-06 2012-05-22 /pmc/articles/PMC3372569/ /pubmed/22707972 http://dx.doi.org/10.4306/pi.2012.9.2.191 Text en Copyright © 2012 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Kim, Il-Soo
Yoon, Ho-Kyoung
Kang, Seung-Gul
Park, Young-Min
Kim, Yong-Ku
Kim, Seung-Hyun
Choi, Jung-Eun
Kim, Leen
Lee, Heon-Jeong
No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patients
title No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patients
title_full No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patients
title_fullStr No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patients
title_full_unstemmed No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patients
title_short No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patients
title_sort no association between pawr gene polymorphisms and tardive dyskinesia in schizophrenia patients
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372569/
https://www.ncbi.nlm.nih.gov/pubmed/22707972
http://dx.doi.org/10.4306/pi.2012.9.2.191
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