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Detectable clonal mosaicism and its relationship to aging and cancer

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls drawn from 13 genome-wide association studies (GWAS), we observed large chromosomal abnormalities in a subset of clones from DNA obtained from blood or buccal samples. Mosaic chromosomal abnormalities, either aneuploidy or copy-ne...

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Autores principales: Jacobs, Kevin B, Yeager, Meredith, Zhou, Weiyin, Wacholder, Sholom, Wang, Zhaoming, Rodriguez-Santiago, Benjamin, Hutchinson, Amy, Deng, Xiang, Liu, Chenwei, Horner, Marie-Josephe, Cullen, Michael, Epstein, Caroline G, Burdett, Laurie, Dean, Michael C, Chatterjee, Nilanjan, Sampson, Joshua, Chung, Charles C, Kovaks, Joseph, Gapstur, Susan M, Stevens, Victoria L, Teras, Lauren T, Gaudet, Mia M, Albanes, Demetrius, Weinstein, Stephanie J, Virtamo, Jarmo, Taylor, Philip R, Freedman, Neal D, Abnet, Christian C, Goldstein, Alisa M, Hu, Nan, Yu, Kai, Yuan, Jian-Min, Liao, Linda, Ding, Ti, Qiao, You-Lin, Gao, Yu-Tang, Koh, Woon-Puay, Xiang, Yong-Bing, Tang, Ze-Zhong, Fan, Jin-Hu, Aldrich, Melinda C, Amos, Christopher, Blot, William J, Bock, Cathryn H, Gillanders, Elizabeth M, Harris, Curtis C, Haiman, Christopher A, Henderson, Brian E, Kolonel, Laurence N, Le Marchand, Loic, McNeill, Lorna H, Rybicki, Benjamin A, Schwartz, Ann G, Signorello, Lisa B, Spitz, Margaret R, Wiencke, John K, Wrensch, Margaret, Wu, Xifeng, Zanetti, Krista A, Ziegler, Regina G, Figueroa, Jonine D, Garcia-Closas, Montserrat, Malats, Nuria, Marenne, Gaelle, Prokunina-Olsson, Ludmila, Baris, Dalsu, Schwenn, Molly, Johnson, Alison, Landi, Maria Teresa, Goldin, Lynn, Consonni, Dario, Bertazzi, Pier Alberto, Rotunno, Melissa, Rajaraman, Preetha, Andersson, Ulrika, Freeman, Laura E Beane, Berg, Christine D, Buring, Julie E, Butler, Mary A, Carreon, Tania, Feychting, Maria, Ahlbom, Anders, Gaziano, J Michael, Giles, Graham G, Hallmans, Goran, Hankinson, Susan E, Hartge, Patricia, Henriksson, Roger, Inskip, Peter D, Johansen, Christoffer, Landgren, Annelie, McKean-Cowdin, Roberta, Michaud, Dominique S, Melin, Beatrice S, Peters, Ulrike, Ruder, Avima M, Sesso, Howard D, Severi, Gianluca, Shu, Xiao-Ou, Visvanathan, Kala, White, Emily, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Silverman, Debra T, Kogevinas, Manolis, Gonzalez, Juan R, Villa, Olaya, Li, Donghui, Duell, Eric J, Risch, Harvey A, Olson, Sara H, Kooperberg, Charles, Wolpin, Brian M, Jiao, Li, Hassan, Manal, Wheeler, William, Arslan, Alan A, Bas Bueno-de-Mesquita, H, Fuchs, Charles S, Gallinger, Steven, Gross, Myron D, Holly, Elizabeth A, Klein, Alison P, LaCroix, Andrea, Mandelson, Margaret T, Petersen, Gloria, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Canzian, Federico, Chang, Kenneth, Cotterchio, Michelle, Giovannucci, Edward L, Goggins, Michael, Bolton, Judith A Hoffman, Jenab, Mazda, Khaw, Kay-Tee, Krogh, Vittorio, Kurtz, Robert C, McWilliams, Robert R, Mendelsohn, Julie B, Rabe, Kari G, Riboli, Elio, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Elena, Joanne W, Yu, Herbert, Amundadottir, Laufey, Stolzenberg-Solomon, Rachael Z, Kraft, Peter, Schumacher, Fredrick, Stram, Daniel, Savage, Sharon A, Mirabello, Lisa, Andrulis, Irene L, Wunder, Jay S, García, Ana Patiño, Sierrasesúmaga, Luis, Barkauskas, Donald A, Gorlick, Richard G, Purdue, Mark, Chow, Wong-Ho, Moore, Lee E, Schwartz, Kendra L, Davis, Faith G, Hsing, Ann W, Berndt, Sonja I, Black, Amanda, Wentzensen, Nicolas, Brinton, Louise A, Lissowska, Jolanta, Peplonska, Beata, McGlynn, Katherine A, Cook, Michael B, Graubard, Barry I, Kratz, Christian P, Greene, Mark H, Erickson, Ralph L, Hunter, David J, Thomas, Gilles, Hoover, Robert N, Real, Francisco X, Fraumeni, Joseph F, Caporaso, Neil E, Tucker, Margaret, Rothman, Nathaniel, Pérez-Jurado, Luis A, Chanock, Stephen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372921/
https://www.ncbi.nlm.nih.gov/pubmed/22561519
http://dx.doi.org/10.1038/ng.2270
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author Jacobs, Kevin B
Yeager, Meredith
Zhou, Weiyin
Wacholder, Sholom
Wang, Zhaoming
Rodriguez-Santiago, Benjamin
Hutchinson, Amy
Deng, Xiang
Liu, Chenwei
Horner, Marie-Josephe
Cullen, Michael
Epstein, Caroline G
Burdett, Laurie
Dean, Michael C
Chatterjee, Nilanjan
Sampson, Joshua
Chung, Charles C
Kovaks, Joseph
Gapstur, Susan M
Stevens, Victoria L
Teras, Lauren T
Gaudet, Mia M
Albanes, Demetrius
Weinstein, Stephanie J
Virtamo, Jarmo
Taylor, Philip R
Freedman, Neal D
Abnet, Christian C
Goldstein, Alisa M
Hu, Nan
Yu, Kai
Yuan, Jian-Min
Liao, Linda
Ding, Ti
Qiao, You-Lin
Gao, Yu-Tang
Koh, Woon-Puay
Xiang, Yong-Bing
Tang, Ze-Zhong
Fan, Jin-Hu
Aldrich, Melinda C
Amos, Christopher
Blot, William J
Bock, Cathryn H
Gillanders, Elizabeth M
Harris, Curtis C
Haiman, Christopher A
Henderson, Brian E
Kolonel, Laurence N
Le Marchand, Loic
McNeill, Lorna H
Rybicki, Benjamin A
Schwartz, Ann G
Signorello, Lisa B
Spitz, Margaret R
Wiencke, John K
Wrensch, Margaret
Wu, Xifeng
Zanetti, Krista A
Ziegler, Regina G
Figueroa, Jonine D
Garcia-Closas, Montserrat
Malats, Nuria
Marenne, Gaelle
Prokunina-Olsson, Ludmila
Baris, Dalsu
Schwenn, Molly
Johnson, Alison
Landi, Maria Teresa
Goldin, Lynn
Consonni, Dario
Bertazzi, Pier Alberto
Rotunno, Melissa
Rajaraman, Preetha
Andersson, Ulrika
Freeman, Laura E Beane
Berg, Christine D
Buring, Julie E
Butler, Mary A
Carreon, Tania
Feychting, Maria
Ahlbom, Anders
Gaziano, J Michael
Giles, Graham G
Hallmans, Goran
Hankinson, Susan E
Hartge, Patricia
Henriksson, Roger
Inskip, Peter D
Johansen, Christoffer
Landgren, Annelie
McKean-Cowdin, Roberta
Michaud, Dominique S
Melin, Beatrice S
Peters, Ulrike
Ruder, Avima M
Sesso, Howard D
Severi, Gianluca
Shu, Xiao-Ou
Visvanathan, Kala
White, Emily
Wolk, Alicja
Zeleniuch-Jacquotte, Anne
Zheng, Wei
Silverman, Debra T
Kogevinas, Manolis
Gonzalez, Juan R
Villa, Olaya
Li, Donghui
Duell, Eric J
Risch, Harvey A
Olson, Sara H
Kooperberg, Charles
Wolpin, Brian M
Jiao, Li
Hassan, Manal
Wheeler, William
Arslan, Alan A
Bas Bueno-de-Mesquita, H
Fuchs, Charles S
Gallinger, Steven
Gross, Myron D
Holly, Elizabeth A
Klein, Alison P
LaCroix, Andrea
Mandelson, Margaret T
Petersen, Gloria
Boutron-Ruault, Marie-Christine
Bracci, Paige M
Canzian, Federico
Chang, Kenneth
Cotterchio, Michelle
Giovannucci, Edward L
Goggins, Michael
Bolton, Judith A Hoffman
Jenab, Mazda
Khaw, Kay-Tee
Krogh, Vittorio
Kurtz, Robert C
McWilliams, Robert R
Mendelsohn, Julie B
Rabe, Kari G
Riboli, Elio
Tjønneland, Anne
Tobias, Geoffrey S
Trichopoulos, Dimitrios
Elena, Joanne W
Yu, Herbert
Amundadottir, Laufey
Stolzenberg-Solomon, Rachael Z
Kraft, Peter
Schumacher, Fredrick
Stram, Daniel
Savage, Sharon A
Mirabello, Lisa
Andrulis, Irene L
Wunder, Jay S
García, Ana Patiño
Sierrasesúmaga, Luis
Barkauskas, Donald A
Gorlick, Richard G
Purdue, Mark
Chow, Wong-Ho
Moore, Lee E
Schwartz, Kendra L
Davis, Faith G
Hsing, Ann W
Berndt, Sonja I
Black, Amanda
Wentzensen, Nicolas
Brinton, Louise A
Lissowska, Jolanta
Peplonska, Beata
McGlynn, Katherine A
Cook, Michael B
Graubard, Barry I
Kratz, Christian P
Greene, Mark H
Erickson, Ralph L
Hunter, David J
Thomas, Gilles
Hoover, Robert N
Real, Francisco X
Fraumeni, Joseph F
Caporaso, Neil E
Tucker, Margaret
Rothman, Nathaniel
Pérez-Jurado, Luis A
Chanock, Stephen J
author_facet Jacobs, Kevin B
Yeager, Meredith
Zhou, Weiyin
Wacholder, Sholom
Wang, Zhaoming
Rodriguez-Santiago, Benjamin
Hutchinson, Amy
Deng, Xiang
Liu, Chenwei
Horner, Marie-Josephe
Cullen, Michael
Epstein, Caroline G
Burdett, Laurie
Dean, Michael C
Chatterjee, Nilanjan
Sampson, Joshua
Chung, Charles C
Kovaks, Joseph
Gapstur, Susan M
Stevens, Victoria L
Teras, Lauren T
Gaudet, Mia M
Albanes, Demetrius
Weinstein, Stephanie J
Virtamo, Jarmo
Taylor, Philip R
Freedman, Neal D
Abnet, Christian C
Goldstein, Alisa M
Hu, Nan
Yu, Kai
Yuan, Jian-Min
Liao, Linda
Ding, Ti
Qiao, You-Lin
Gao, Yu-Tang
Koh, Woon-Puay
Xiang, Yong-Bing
Tang, Ze-Zhong
Fan, Jin-Hu
Aldrich, Melinda C
Amos, Christopher
Blot, William J
Bock, Cathryn H
Gillanders, Elizabeth M
Harris, Curtis C
Haiman, Christopher A
Henderson, Brian E
Kolonel, Laurence N
Le Marchand, Loic
McNeill, Lorna H
Rybicki, Benjamin A
Schwartz, Ann G
Signorello, Lisa B
Spitz, Margaret R
Wiencke, John K
Wrensch, Margaret
Wu, Xifeng
Zanetti, Krista A
Ziegler, Regina G
Figueroa, Jonine D
Garcia-Closas, Montserrat
Malats, Nuria
Marenne, Gaelle
Prokunina-Olsson, Ludmila
Baris, Dalsu
Schwenn, Molly
Johnson, Alison
Landi, Maria Teresa
Goldin, Lynn
Consonni, Dario
Bertazzi, Pier Alberto
Rotunno, Melissa
Rajaraman, Preetha
Andersson, Ulrika
Freeman, Laura E Beane
Berg, Christine D
Buring, Julie E
Butler, Mary A
Carreon, Tania
Feychting, Maria
Ahlbom, Anders
Gaziano, J Michael
Giles, Graham G
Hallmans, Goran
Hankinson, Susan E
Hartge, Patricia
Henriksson, Roger
Inskip, Peter D
Johansen, Christoffer
Landgren, Annelie
McKean-Cowdin, Roberta
Michaud, Dominique S
Melin, Beatrice S
Peters, Ulrike
Ruder, Avima M
Sesso, Howard D
Severi, Gianluca
Shu, Xiao-Ou
Visvanathan, Kala
White, Emily
Wolk, Alicja
Zeleniuch-Jacquotte, Anne
Zheng, Wei
Silverman, Debra T
Kogevinas, Manolis
Gonzalez, Juan R
Villa, Olaya
Li, Donghui
Duell, Eric J
Risch, Harvey A
Olson, Sara H
Kooperberg, Charles
Wolpin, Brian M
Jiao, Li
Hassan, Manal
Wheeler, William
Arslan, Alan A
Bas Bueno-de-Mesquita, H
Fuchs, Charles S
Gallinger, Steven
Gross, Myron D
Holly, Elizabeth A
Klein, Alison P
LaCroix, Andrea
Mandelson, Margaret T
Petersen, Gloria
Boutron-Ruault, Marie-Christine
Bracci, Paige M
Canzian, Federico
Chang, Kenneth
Cotterchio, Michelle
Giovannucci, Edward L
Goggins, Michael
Bolton, Judith A Hoffman
Jenab, Mazda
Khaw, Kay-Tee
Krogh, Vittorio
Kurtz, Robert C
McWilliams, Robert R
Mendelsohn, Julie B
Rabe, Kari G
Riboli, Elio
Tjønneland, Anne
Tobias, Geoffrey S
Trichopoulos, Dimitrios
Elena, Joanne W
Yu, Herbert
Amundadottir, Laufey
Stolzenberg-Solomon, Rachael Z
Kraft, Peter
Schumacher, Fredrick
Stram, Daniel
Savage, Sharon A
Mirabello, Lisa
Andrulis, Irene L
Wunder, Jay S
García, Ana Patiño
Sierrasesúmaga, Luis
Barkauskas, Donald A
Gorlick, Richard G
Purdue, Mark
Chow, Wong-Ho
Moore, Lee E
Schwartz, Kendra L
Davis, Faith G
Hsing, Ann W
Berndt, Sonja I
Black, Amanda
Wentzensen, Nicolas
Brinton, Louise A
Lissowska, Jolanta
Peplonska, Beata
McGlynn, Katherine A
Cook, Michael B
Graubard, Barry I
Kratz, Christian P
Greene, Mark H
Erickson, Ralph L
Hunter, David J
Thomas, Gilles
Hoover, Robert N
Real, Francisco X
Fraumeni, Joseph F
Caporaso, Neil E
Tucker, Margaret
Rothman, Nathaniel
Pérez-Jurado, Luis A
Chanock, Stephen J
author_sort Jacobs, Kevin B
collection PubMed
description In an analysis of 31,717 cancer cases and 26,136 cancer-free controls drawn from 13 genome-wide association studies (GWAS), we observed large chromosomal abnormalities in a subset of clones from DNA obtained from blood or buccal samples. Mosaic chromosomal abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of size >2 Mb were observed in autosomes of 517 individuals (0.89%) with abnormal cell proportions between 7% and 95%. In cancer-free individuals, the frequency increased with age; 0.23% under 50 and 1.91% between 75 and 79 (p=4.8×10(−8)). Mosaic abnormalities were more frequent in individuals with solid-tumors (0.97% versus 0.74% in cancer-free individuals, OR=1.25, p=0.016), with a stronger association for cases who had DNA collected prior to diagnosis or treatment (OR=1.45, p=0.0005). Detectable clonal mosaicism was common in individuals for whom DNA was collected at least one year prior to diagnosis of leukemia compared to cancer-free individuals (OR=35.4, p=3.8×10(−11)). These findings underscore the importance of the role and time-dependent nature of somatic events in the etiology of cancer and other late-onset diseases.
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spelling pubmed-33729212012-10-03 Detectable clonal mosaicism and its relationship to aging and cancer Jacobs, Kevin B Yeager, Meredith Zhou, Weiyin Wacholder, Sholom Wang, Zhaoming Rodriguez-Santiago, Benjamin Hutchinson, Amy Deng, Xiang Liu, Chenwei Horner, Marie-Josephe Cullen, Michael Epstein, Caroline G Burdett, Laurie Dean, Michael C Chatterjee, Nilanjan Sampson, Joshua Chung, Charles C Kovaks, Joseph Gapstur, Susan M Stevens, Victoria L Teras, Lauren T Gaudet, Mia M Albanes, Demetrius Weinstein, Stephanie J Virtamo, Jarmo Taylor, Philip R Freedman, Neal D Abnet, Christian C Goldstein, Alisa M Hu, Nan Yu, Kai Yuan, Jian-Min Liao, Linda Ding, Ti Qiao, You-Lin Gao, Yu-Tang Koh, Woon-Puay Xiang, Yong-Bing Tang, Ze-Zhong Fan, Jin-Hu Aldrich, Melinda C Amos, Christopher Blot, William J Bock, Cathryn H Gillanders, Elizabeth M Harris, Curtis C Haiman, Christopher A Henderson, Brian E Kolonel, Laurence N Le Marchand, Loic McNeill, Lorna H Rybicki, Benjamin A Schwartz, Ann G Signorello, Lisa B Spitz, Margaret R Wiencke, John K Wrensch, Margaret Wu, Xifeng Zanetti, Krista A Ziegler, Regina G Figueroa, Jonine D Garcia-Closas, Montserrat Malats, Nuria Marenne, Gaelle Prokunina-Olsson, Ludmila Baris, Dalsu Schwenn, Molly Johnson, Alison Landi, Maria Teresa Goldin, Lynn Consonni, Dario Bertazzi, Pier Alberto Rotunno, Melissa Rajaraman, Preetha Andersson, Ulrika Freeman, Laura E Beane Berg, Christine D Buring, Julie E Butler, Mary A Carreon, Tania Feychting, Maria Ahlbom, Anders Gaziano, J Michael Giles, Graham G Hallmans, Goran Hankinson, Susan E Hartge, Patricia Henriksson, Roger Inskip, Peter D Johansen, Christoffer Landgren, Annelie McKean-Cowdin, Roberta Michaud, Dominique S Melin, Beatrice S Peters, Ulrike Ruder, Avima M Sesso, Howard D Severi, Gianluca Shu, Xiao-Ou Visvanathan, Kala White, Emily Wolk, Alicja Zeleniuch-Jacquotte, Anne Zheng, Wei Silverman, Debra T Kogevinas, Manolis Gonzalez, Juan R Villa, Olaya Li, Donghui Duell, Eric J Risch, Harvey A Olson, Sara H Kooperberg, Charles Wolpin, Brian M Jiao, Li Hassan, Manal Wheeler, William Arslan, Alan A Bas Bueno-de-Mesquita, H Fuchs, Charles S Gallinger, Steven Gross, Myron D Holly, Elizabeth A Klein, Alison P LaCroix, Andrea Mandelson, Margaret T Petersen, Gloria Boutron-Ruault, Marie-Christine Bracci, Paige M Canzian, Federico Chang, Kenneth Cotterchio, Michelle Giovannucci, Edward L Goggins, Michael Bolton, Judith A Hoffman Jenab, Mazda Khaw, Kay-Tee Krogh, Vittorio Kurtz, Robert C McWilliams, Robert R Mendelsohn, Julie B Rabe, Kari G Riboli, Elio Tjønneland, Anne Tobias, Geoffrey S Trichopoulos, Dimitrios Elena, Joanne W Yu, Herbert Amundadottir, Laufey Stolzenberg-Solomon, Rachael Z Kraft, Peter Schumacher, Fredrick Stram, Daniel Savage, Sharon A Mirabello, Lisa Andrulis, Irene L Wunder, Jay S García, Ana Patiño Sierrasesúmaga, Luis Barkauskas, Donald A Gorlick, Richard G Purdue, Mark Chow, Wong-Ho Moore, Lee E Schwartz, Kendra L Davis, Faith G Hsing, Ann W Berndt, Sonja I Black, Amanda Wentzensen, Nicolas Brinton, Louise A Lissowska, Jolanta Peplonska, Beata McGlynn, Katherine A Cook, Michael B Graubard, Barry I Kratz, Christian P Greene, Mark H Erickson, Ralph L Hunter, David J Thomas, Gilles Hoover, Robert N Real, Francisco X Fraumeni, Joseph F Caporaso, Neil E Tucker, Margaret Rothman, Nathaniel Pérez-Jurado, Luis A Chanock, Stephen J Nat Genet Article In an analysis of 31,717 cancer cases and 26,136 cancer-free controls drawn from 13 genome-wide association studies (GWAS), we observed large chromosomal abnormalities in a subset of clones from DNA obtained from blood or buccal samples. Mosaic chromosomal abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of size >2 Mb were observed in autosomes of 517 individuals (0.89%) with abnormal cell proportions between 7% and 95%. In cancer-free individuals, the frequency increased with age; 0.23% under 50 and 1.91% between 75 and 79 (p=4.8×10(−8)). Mosaic abnormalities were more frequent in individuals with solid-tumors (0.97% versus 0.74% in cancer-free individuals, OR=1.25, p=0.016), with a stronger association for cases who had DNA collected prior to diagnosis or treatment (OR=1.45, p=0.0005). Detectable clonal mosaicism was common in individuals for whom DNA was collected at least one year prior to diagnosis of leukemia compared to cancer-free individuals (OR=35.4, p=3.8×10(−11)). These findings underscore the importance of the role and time-dependent nature of somatic events in the etiology of cancer and other late-onset diseases. 2012-05-06 /pmc/articles/PMC3372921/ /pubmed/22561519 http://dx.doi.org/10.1038/ng.2270 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Jacobs, Kevin B
Yeager, Meredith
Zhou, Weiyin
Wacholder, Sholom
Wang, Zhaoming
Rodriguez-Santiago, Benjamin
Hutchinson, Amy
Deng, Xiang
Liu, Chenwei
Horner, Marie-Josephe
Cullen, Michael
Epstein, Caroline G
Burdett, Laurie
Dean, Michael C
Chatterjee, Nilanjan
Sampson, Joshua
Chung, Charles C
Kovaks, Joseph
Gapstur, Susan M
Stevens, Victoria L
Teras, Lauren T
Gaudet, Mia M
Albanes, Demetrius
Weinstein, Stephanie J
Virtamo, Jarmo
Taylor, Philip R
Freedman, Neal D
Abnet, Christian C
Goldstein, Alisa M
Hu, Nan
Yu, Kai
Yuan, Jian-Min
Liao, Linda
Ding, Ti
Qiao, You-Lin
Gao, Yu-Tang
Koh, Woon-Puay
Xiang, Yong-Bing
Tang, Ze-Zhong
Fan, Jin-Hu
Aldrich, Melinda C
Amos, Christopher
Blot, William J
Bock, Cathryn H
Gillanders, Elizabeth M
Harris, Curtis C
Haiman, Christopher A
Henderson, Brian E
Kolonel, Laurence N
Le Marchand, Loic
McNeill, Lorna H
Rybicki, Benjamin A
Schwartz, Ann G
Signorello, Lisa B
Spitz, Margaret R
Wiencke, John K
Wrensch, Margaret
Wu, Xifeng
Zanetti, Krista A
Ziegler, Regina G
Figueroa, Jonine D
Garcia-Closas, Montserrat
Malats, Nuria
Marenne, Gaelle
Prokunina-Olsson, Ludmila
Baris, Dalsu
Schwenn, Molly
Johnson, Alison
Landi, Maria Teresa
Goldin, Lynn
Consonni, Dario
Bertazzi, Pier Alberto
Rotunno, Melissa
Rajaraman, Preetha
Andersson, Ulrika
Freeman, Laura E Beane
Berg, Christine D
Buring, Julie E
Butler, Mary A
Carreon, Tania
Feychting, Maria
Ahlbom, Anders
Gaziano, J Michael
Giles, Graham G
Hallmans, Goran
Hankinson, Susan E
Hartge, Patricia
Henriksson, Roger
Inskip, Peter D
Johansen, Christoffer
Landgren, Annelie
McKean-Cowdin, Roberta
Michaud, Dominique S
Melin, Beatrice S
Peters, Ulrike
Ruder, Avima M
Sesso, Howard D
Severi, Gianluca
Shu, Xiao-Ou
Visvanathan, Kala
White, Emily
Wolk, Alicja
Zeleniuch-Jacquotte, Anne
Zheng, Wei
Silverman, Debra T
Kogevinas, Manolis
Gonzalez, Juan R
Villa, Olaya
Li, Donghui
Duell, Eric J
Risch, Harvey A
Olson, Sara H
Kooperberg, Charles
Wolpin, Brian M
Jiao, Li
Hassan, Manal
Wheeler, William
Arslan, Alan A
Bas Bueno-de-Mesquita, H
Fuchs, Charles S
Gallinger, Steven
Gross, Myron D
Holly, Elizabeth A
Klein, Alison P
LaCroix, Andrea
Mandelson, Margaret T
Petersen, Gloria
Boutron-Ruault, Marie-Christine
Bracci, Paige M
Canzian, Federico
Chang, Kenneth
Cotterchio, Michelle
Giovannucci, Edward L
Goggins, Michael
Bolton, Judith A Hoffman
Jenab, Mazda
Khaw, Kay-Tee
Krogh, Vittorio
Kurtz, Robert C
McWilliams, Robert R
Mendelsohn, Julie B
Rabe, Kari G
Riboli, Elio
Tjønneland, Anne
Tobias, Geoffrey S
Trichopoulos, Dimitrios
Elena, Joanne W
Yu, Herbert
Amundadottir, Laufey
Stolzenberg-Solomon, Rachael Z
Kraft, Peter
Schumacher, Fredrick
Stram, Daniel
Savage, Sharon A
Mirabello, Lisa
Andrulis, Irene L
Wunder, Jay S
García, Ana Patiño
Sierrasesúmaga, Luis
Barkauskas, Donald A
Gorlick, Richard G
Purdue, Mark
Chow, Wong-Ho
Moore, Lee E
Schwartz, Kendra L
Davis, Faith G
Hsing, Ann W
Berndt, Sonja I
Black, Amanda
Wentzensen, Nicolas
Brinton, Louise A
Lissowska, Jolanta
Peplonska, Beata
McGlynn, Katherine A
Cook, Michael B
Graubard, Barry I
Kratz, Christian P
Greene, Mark H
Erickson, Ralph L
Hunter, David J
Thomas, Gilles
Hoover, Robert N
Real, Francisco X
Fraumeni, Joseph F
Caporaso, Neil E
Tucker, Margaret
Rothman, Nathaniel
Pérez-Jurado, Luis A
Chanock, Stephen J
Detectable clonal mosaicism and its relationship to aging and cancer
title Detectable clonal mosaicism and its relationship to aging and cancer
title_full Detectable clonal mosaicism and its relationship to aging and cancer
title_fullStr Detectable clonal mosaicism and its relationship to aging and cancer
title_full_unstemmed Detectable clonal mosaicism and its relationship to aging and cancer
title_short Detectable clonal mosaicism and its relationship to aging and cancer
title_sort detectable clonal mosaicism and its relationship to aging and cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372921/
https://www.ncbi.nlm.nih.gov/pubmed/22561519
http://dx.doi.org/10.1038/ng.2270
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AT epsteincarolineg detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT burdettlaurie detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT deanmichaelc detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT chatterjeenilanjan detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT sampsonjoshua detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT chungcharlesc detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT kovaksjoseph detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT gapstursusanm detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT stevensvictorial detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT teraslaurent detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT gaudetmiam detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT albanesdemetrius detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT weinsteinstephaniej detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT virtamojarmo detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT taylorphilipr detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT freedmanneald detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT abnetchristianc detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT goldsteinalisam detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT hunan detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT yukai detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT yuanjianmin detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT liaolinda detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT dingti detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT qiaoyoulin detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT gaoyutang detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT kohwoonpuay detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT xiangyongbing detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT tangzezhong detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT fanjinhu detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT aldrichmelindac detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT amoschristopher detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT blotwilliamj detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT bockcathrynh detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT gillanderselizabethm detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT harriscurtisc detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT haimanchristophera detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT hendersonbriane detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT kolonellaurencen detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT lemarchandloic detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT mcneilllornah detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT rybickibenjamina detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT schwartzanng detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT signorellolisab detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT spitzmargaretr detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT wienckejohnk detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT wrenschmargaret detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT wuxifeng detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT zanettikristaa detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT zieglerreginag detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT figueroajonined detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT garciaclosasmontserrat detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT malatsnuria detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT marennegaelle detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT prokuninaolssonludmila detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT barisdalsu detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT schwennmolly detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT johnsonalison detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT landimariateresa detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT goldinlynn detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT consonnidario detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT bertazzipieralberto detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT rotunnomelissa detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT rajaramanpreetha detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT anderssonulrika detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT freemanlauraebeane detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT bergchristined detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT buringjuliee detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT butlermarya detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT carreontania detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT feychtingmaria detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT ahlbomanders detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT gazianojmichael detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT gilesgrahamg detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT hallmansgoran detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT hankinsonsusane detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT hartgepatricia detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT henrikssonroger detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT inskippeterd detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT johansenchristoffer detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT landgrenannelie detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT mckeancowdinroberta detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT michauddominiques detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT melinbeatrices detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT petersulrike detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT ruderavimam detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT sessohowardd detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT severigianluca detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT shuxiaoou detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT visvanathankala detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT whiteemily detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT wolkalicja detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT zeleniuchjacquotteanne detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT zhengwei detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT silvermandebrat detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT kogevinasmanolis detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT gonzalezjuanr detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT villaolaya detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT lidonghui detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT duellericj detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT rischharveya detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT olsonsarah detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT kooperbergcharles detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT wolpinbrianm detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT jiaoli detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT hassanmanal detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT wheelerwilliam detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT arslanalana detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT basbuenodemesquitah detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT fuchscharless detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT gallingersteven detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT grossmyrond detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT hollyelizabetha detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT kleinalisonp detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT lacroixandrea detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT mandelsonmargarett detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT petersengloria detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT boutronruaultmariechristine detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT braccipaigem detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT canzianfederico detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT changkenneth detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT cotterchiomichelle detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT giovannucciedwardl detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT gogginsmichael detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT boltonjudithahoffman detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT jenabmazda detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT khawkaytee detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT kroghvittorio detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT kurtzrobertc detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT mcwilliamsrobertr detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT mendelsohnjulieb detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT rabekarig detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT ribolielio detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT tjønnelandanne detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT tobiasgeoffreys detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT trichopoulosdimitrios detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT elenajoannew detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT yuherbert detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT amundadottirlaufey detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT stolzenbergsolomonrachaelz detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT kraftpeter detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT schumacherfredrick detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT stramdaniel detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT savagesharona detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT mirabellolisa detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT andrulisirenel detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT wunderjays detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT garciaanapatino detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT sierrasesumagaluis detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT barkauskasdonalda detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT gorlickrichardg detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT purduemark detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT chowwongho detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT mooreleee detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT schwartzkendral detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT davisfaithg detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT hsingannw detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT berndtsonjai detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT blackamanda detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT wentzensennicolas detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT brintonlouisea detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT lissowskajolanta detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT peplonskabeata detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT mcglynnkatherinea detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT cookmichaelb detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT graubardbarryi detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT kratzchristianp detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT greenemarkh detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT ericksonralphl detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT hunterdavidj detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT thomasgilles detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT hooverrobertn detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT realfranciscox detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT fraumenijosephf detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT caporasoneile detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT tuckermargaret detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT rothmannathaniel detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT perezjuradoluisa detectableclonalmosaicismanditsrelationshiptoagingandcancer
AT chanockstephenj detectableclonalmosaicismanditsrelationshiptoagingandcancer