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Detectable clonal mosaicism and its relationship to aging and cancer
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls drawn from 13 genome-wide association studies (GWAS), we observed large chromosomal abnormalities in a subset of clones from DNA obtained from blood or buccal samples. Mosaic chromosomal abnormalities, either aneuploidy or copy-ne...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372921/ https://www.ncbi.nlm.nih.gov/pubmed/22561519 http://dx.doi.org/10.1038/ng.2270 |
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author | Jacobs, Kevin B Yeager, Meredith Zhou, Weiyin Wacholder, Sholom Wang, Zhaoming Rodriguez-Santiago, Benjamin Hutchinson, Amy Deng, Xiang Liu, Chenwei Horner, Marie-Josephe Cullen, Michael Epstein, Caroline G Burdett, Laurie Dean, Michael C Chatterjee, Nilanjan Sampson, Joshua Chung, Charles C Kovaks, Joseph Gapstur, Susan M Stevens, Victoria L Teras, Lauren T Gaudet, Mia M Albanes, Demetrius Weinstein, Stephanie J Virtamo, Jarmo Taylor, Philip R Freedman, Neal D Abnet, Christian C Goldstein, Alisa M Hu, Nan Yu, Kai Yuan, Jian-Min Liao, Linda Ding, Ti Qiao, You-Lin Gao, Yu-Tang Koh, Woon-Puay Xiang, Yong-Bing Tang, Ze-Zhong Fan, Jin-Hu Aldrich, Melinda C Amos, Christopher Blot, William J Bock, Cathryn H Gillanders, Elizabeth M Harris, Curtis C Haiman, Christopher A Henderson, Brian E Kolonel, Laurence N Le Marchand, Loic McNeill, Lorna H Rybicki, Benjamin A Schwartz, Ann G Signorello, Lisa B Spitz, Margaret R Wiencke, John K Wrensch, Margaret Wu, Xifeng Zanetti, Krista A Ziegler, Regina G Figueroa, Jonine D Garcia-Closas, Montserrat Malats, Nuria Marenne, Gaelle Prokunina-Olsson, Ludmila Baris, Dalsu Schwenn, Molly Johnson, Alison Landi, Maria Teresa Goldin, Lynn Consonni, Dario Bertazzi, Pier Alberto Rotunno, Melissa Rajaraman, Preetha Andersson, Ulrika Freeman, Laura E Beane Berg, Christine D Buring, Julie E Butler, Mary A Carreon, Tania Feychting, Maria Ahlbom, Anders Gaziano, J Michael Giles, Graham G Hallmans, Goran Hankinson, Susan E Hartge, Patricia Henriksson, Roger Inskip, Peter D Johansen, Christoffer Landgren, Annelie McKean-Cowdin, Roberta Michaud, Dominique S Melin, Beatrice S Peters, Ulrike Ruder, Avima M Sesso, Howard D Severi, Gianluca Shu, Xiao-Ou Visvanathan, Kala White, Emily Wolk, Alicja Zeleniuch-Jacquotte, Anne Zheng, Wei Silverman, Debra T Kogevinas, Manolis Gonzalez, Juan R Villa, Olaya Li, Donghui Duell, Eric J Risch, Harvey A Olson, Sara H Kooperberg, Charles Wolpin, Brian M Jiao, Li Hassan, Manal Wheeler, William Arslan, Alan A Bas Bueno-de-Mesquita, H Fuchs, Charles S Gallinger, Steven Gross, Myron D Holly, Elizabeth A Klein, Alison P LaCroix, Andrea Mandelson, Margaret T Petersen, Gloria Boutron-Ruault, Marie-Christine Bracci, Paige M Canzian, Federico Chang, Kenneth Cotterchio, Michelle Giovannucci, Edward L Goggins, Michael Bolton, Judith A Hoffman Jenab, Mazda Khaw, Kay-Tee Krogh, Vittorio Kurtz, Robert C McWilliams, Robert R Mendelsohn, Julie B Rabe, Kari G Riboli, Elio Tjønneland, Anne Tobias, Geoffrey S Trichopoulos, Dimitrios Elena, Joanne W Yu, Herbert Amundadottir, Laufey Stolzenberg-Solomon, Rachael Z Kraft, Peter Schumacher, Fredrick Stram, Daniel Savage, Sharon A Mirabello, Lisa Andrulis, Irene L Wunder, Jay S García, Ana Patiño Sierrasesúmaga, Luis Barkauskas, Donald A Gorlick, Richard G Purdue, Mark Chow, Wong-Ho Moore, Lee E Schwartz, Kendra L Davis, Faith G Hsing, Ann W Berndt, Sonja I Black, Amanda Wentzensen, Nicolas Brinton, Louise A Lissowska, Jolanta Peplonska, Beata McGlynn, Katherine A Cook, Michael B Graubard, Barry I Kratz, Christian P Greene, Mark H Erickson, Ralph L Hunter, David J Thomas, Gilles Hoover, Robert N Real, Francisco X Fraumeni, Joseph F Caporaso, Neil E Tucker, Margaret Rothman, Nathaniel Pérez-Jurado, Luis A Chanock, Stephen J |
author_facet | Jacobs, Kevin B Yeager, Meredith Zhou, Weiyin Wacholder, Sholom Wang, Zhaoming Rodriguez-Santiago, Benjamin Hutchinson, Amy Deng, Xiang Liu, Chenwei Horner, Marie-Josephe Cullen, Michael Epstein, Caroline G Burdett, Laurie Dean, Michael C Chatterjee, Nilanjan Sampson, Joshua Chung, Charles C Kovaks, Joseph Gapstur, Susan M Stevens, Victoria L Teras, Lauren T Gaudet, Mia M Albanes, Demetrius Weinstein, Stephanie J Virtamo, Jarmo Taylor, Philip R Freedman, Neal D Abnet, Christian C Goldstein, Alisa M Hu, Nan Yu, Kai Yuan, Jian-Min Liao, Linda Ding, Ti Qiao, You-Lin Gao, Yu-Tang Koh, Woon-Puay Xiang, Yong-Bing Tang, Ze-Zhong Fan, Jin-Hu Aldrich, Melinda C Amos, Christopher Blot, William J Bock, Cathryn H Gillanders, Elizabeth M Harris, Curtis C Haiman, Christopher A Henderson, Brian E Kolonel, Laurence N Le Marchand, Loic McNeill, Lorna H Rybicki, Benjamin A Schwartz, Ann G Signorello, Lisa B Spitz, Margaret R Wiencke, John K Wrensch, Margaret Wu, Xifeng Zanetti, Krista A Ziegler, Regina G Figueroa, Jonine D Garcia-Closas, Montserrat Malats, Nuria Marenne, Gaelle Prokunina-Olsson, Ludmila Baris, Dalsu Schwenn, Molly Johnson, Alison Landi, Maria Teresa Goldin, Lynn Consonni, Dario Bertazzi, Pier Alberto Rotunno, Melissa Rajaraman, Preetha Andersson, Ulrika Freeman, Laura E Beane Berg, Christine D Buring, Julie E Butler, Mary A Carreon, Tania Feychting, Maria Ahlbom, Anders Gaziano, J Michael Giles, Graham G Hallmans, Goran Hankinson, Susan E Hartge, Patricia Henriksson, Roger Inskip, Peter D Johansen, Christoffer Landgren, Annelie McKean-Cowdin, Roberta Michaud, Dominique S Melin, Beatrice S Peters, Ulrike Ruder, Avima M Sesso, Howard D Severi, Gianluca Shu, Xiao-Ou Visvanathan, Kala White, Emily Wolk, Alicja Zeleniuch-Jacquotte, Anne Zheng, Wei Silverman, Debra T Kogevinas, Manolis Gonzalez, Juan R Villa, Olaya Li, Donghui Duell, Eric J Risch, Harvey A Olson, Sara H Kooperberg, Charles Wolpin, Brian M Jiao, Li Hassan, Manal Wheeler, William Arslan, Alan A Bas Bueno-de-Mesquita, H Fuchs, Charles S Gallinger, Steven Gross, Myron D Holly, Elizabeth A Klein, Alison P LaCroix, Andrea Mandelson, Margaret T Petersen, Gloria Boutron-Ruault, Marie-Christine Bracci, Paige M Canzian, Federico Chang, Kenneth Cotterchio, Michelle Giovannucci, Edward L Goggins, Michael Bolton, Judith A Hoffman Jenab, Mazda Khaw, Kay-Tee Krogh, Vittorio Kurtz, Robert C McWilliams, Robert R Mendelsohn, Julie B Rabe, Kari G Riboli, Elio Tjønneland, Anne Tobias, Geoffrey S Trichopoulos, Dimitrios Elena, Joanne W Yu, Herbert Amundadottir, Laufey Stolzenberg-Solomon, Rachael Z Kraft, Peter Schumacher, Fredrick Stram, Daniel Savage, Sharon A Mirabello, Lisa Andrulis, Irene L Wunder, Jay S García, Ana Patiño Sierrasesúmaga, Luis Barkauskas, Donald A Gorlick, Richard G Purdue, Mark Chow, Wong-Ho Moore, Lee E Schwartz, Kendra L Davis, Faith G Hsing, Ann W Berndt, Sonja I Black, Amanda Wentzensen, Nicolas Brinton, Louise A Lissowska, Jolanta Peplonska, Beata McGlynn, Katherine A Cook, Michael B Graubard, Barry I Kratz, Christian P Greene, Mark H Erickson, Ralph L Hunter, David J Thomas, Gilles Hoover, Robert N Real, Francisco X Fraumeni, Joseph F Caporaso, Neil E Tucker, Margaret Rothman, Nathaniel Pérez-Jurado, Luis A Chanock, Stephen J |
author_sort | Jacobs, Kevin B |
collection | PubMed |
description | In an analysis of 31,717 cancer cases and 26,136 cancer-free controls drawn from 13 genome-wide association studies (GWAS), we observed large chromosomal abnormalities in a subset of clones from DNA obtained from blood or buccal samples. Mosaic chromosomal abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of size >2 Mb were observed in autosomes of 517 individuals (0.89%) with abnormal cell proportions between 7% and 95%. In cancer-free individuals, the frequency increased with age; 0.23% under 50 and 1.91% between 75 and 79 (p=4.8×10(−8)). Mosaic abnormalities were more frequent in individuals with solid-tumors (0.97% versus 0.74% in cancer-free individuals, OR=1.25, p=0.016), with a stronger association for cases who had DNA collected prior to diagnosis or treatment (OR=1.45, p=0.0005). Detectable clonal mosaicism was common in individuals for whom DNA was collected at least one year prior to diagnosis of leukemia compared to cancer-free individuals (OR=35.4, p=3.8×10(−11)). These findings underscore the importance of the role and time-dependent nature of somatic events in the etiology of cancer and other late-onset diseases. |
format | Online Article Text |
id | pubmed-3372921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
record_format | MEDLINE/PubMed |
spelling | pubmed-33729212012-10-03 Detectable clonal mosaicism and its relationship to aging and cancer Jacobs, Kevin B Yeager, Meredith Zhou, Weiyin Wacholder, Sholom Wang, Zhaoming Rodriguez-Santiago, Benjamin Hutchinson, Amy Deng, Xiang Liu, Chenwei Horner, Marie-Josephe Cullen, Michael Epstein, Caroline G Burdett, Laurie Dean, Michael C Chatterjee, Nilanjan Sampson, Joshua Chung, Charles C Kovaks, Joseph Gapstur, Susan M Stevens, Victoria L Teras, Lauren T Gaudet, Mia M Albanes, Demetrius Weinstein, Stephanie J Virtamo, Jarmo Taylor, Philip R Freedman, Neal D Abnet, Christian C Goldstein, Alisa M Hu, Nan Yu, Kai Yuan, Jian-Min Liao, Linda Ding, Ti Qiao, You-Lin Gao, Yu-Tang Koh, Woon-Puay Xiang, Yong-Bing Tang, Ze-Zhong Fan, Jin-Hu Aldrich, Melinda C Amos, Christopher Blot, William J Bock, Cathryn H Gillanders, Elizabeth M Harris, Curtis C Haiman, Christopher A Henderson, Brian E Kolonel, Laurence N Le Marchand, Loic McNeill, Lorna H Rybicki, Benjamin A Schwartz, Ann G Signorello, Lisa B Spitz, Margaret R Wiencke, John K Wrensch, Margaret Wu, Xifeng Zanetti, Krista A Ziegler, Regina G Figueroa, Jonine D Garcia-Closas, Montserrat Malats, Nuria Marenne, Gaelle Prokunina-Olsson, Ludmila Baris, Dalsu Schwenn, Molly Johnson, Alison Landi, Maria Teresa Goldin, Lynn Consonni, Dario Bertazzi, Pier Alberto Rotunno, Melissa Rajaraman, Preetha Andersson, Ulrika Freeman, Laura E Beane Berg, Christine D Buring, Julie E Butler, Mary A Carreon, Tania Feychting, Maria Ahlbom, Anders Gaziano, J Michael Giles, Graham G Hallmans, Goran Hankinson, Susan E Hartge, Patricia Henriksson, Roger Inskip, Peter D Johansen, Christoffer Landgren, Annelie McKean-Cowdin, Roberta Michaud, Dominique S Melin, Beatrice S Peters, Ulrike Ruder, Avima M Sesso, Howard D Severi, Gianluca Shu, Xiao-Ou Visvanathan, Kala White, Emily Wolk, Alicja Zeleniuch-Jacquotte, Anne Zheng, Wei Silverman, Debra T Kogevinas, Manolis Gonzalez, Juan R Villa, Olaya Li, Donghui Duell, Eric J Risch, Harvey A Olson, Sara H Kooperberg, Charles Wolpin, Brian M Jiao, Li Hassan, Manal Wheeler, William Arslan, Alan A Bas Bueno-de-Mesquita, H Fuchs, Charles S Gallinger, Steven Gross, Myron D Holly, Elizabeth A Klein, Alison P LaCroix, Andrea Mandelson, Margaret T Petersen, Gloria Boutron-Ruault, Marie-Christine Bracci, Paige M Canzian, Federico Chang, Kenneth Cotterchio, Michelle Giovannucci, Edward L Goggins, Michael Bolton, Judith A Hoffman Jenab, Mazda Khaw, Kay-Tee Krogh, Vittorio Kurtz, Robert C McWilliams, Robert R Mendelsohn, Julie B Rabe, Kari G Riboli, Elio Tjønneland, Anne Tobias, Geoffrey S Trichopoulos, Dimitrios Elena, Joanne W Yu, Herbert Amundadottir, Laufey Stolzenberg-Solomon, Rachael Z Kraft, Peter Schumacher, Fredrick Stram, Daniel Savage, Sharon A Mirabello, Lisa Andrulis, Irene L Wunder, Jay S García, Ana Patiño Sierrasesúmaga, Luis Barkauskas, Donald A Gorlick, Richard G Purdue, Mark Chow, Wong-Ho Moore, Lee E Schwartz, Kendra L Davis, Faith G Hsing, Ann W Berndt, Sonja I Black, Amanda Wentzensen, Nicolas Brinton, Louise A Lissowska, Jolanta Peplonska, Beata McGlynn, Katherine A Cook, Michael B Graubard, Barry I Kratz, Christian P Greene, Mark H Erickson, Ralph L Hunter, David J Thomas, Gilles Hoover, Robert N Real, Francisco X Fraumeni, Joseph F Caporaso, Neil E Tucker, Margaret Rothman, Nathaniel Pérez-Jurado, Luis A Chanock, Stephen J Nat Genet Article In an analysis of 31,717 cancer cases and 26,136 cancer-free controls drawn from 13 genome-wide association studies (GWAS), we observed large chromosomal abnormalities in a subset of clones from DNA obtained from blood or buccal samples. Mosaic chromosomal abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of size >2 Mb were observed in autosomes of 517 individuals (0.89%) with abnormal cell proportions between 7% and 95%. In cancer-free individuals, the frequency increased with age; 0.23% under 50 and 1.91% between 75 and 79 (p=4.8×10(−8)). Mosaic abnormalities were more frequent in individuals with solid-tumors (0.97% versus 0.74% in cancer-free individuals, OR=1.25, p=0.016), with a stronger association for cases who had DNA collected prior to diagnosis or treatment (OR=1.45, p=0.0005). Detectable clonal mosaicism was common in individuals for whom DNA was collected at least one year prior to diagnosis of leukemia compared to cancer-free individuals (OR=35.4, p=3.8×10(−11)). These findings underscore the importance of the role and time-dependent nature of somatic events in the etiology of cancer and other late-onset diseases. 2012-05-06 /pmc/articles/PMC3372921/ /pubmed/22561519 http://dx.doi.org/10.1038/ng.2270 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Jacobs, Kevin B Yeager, Meredith Zhou, Weiyin Wacholder, Sholom Wang, Zhaoming Rodriguez-Santiago, Benjamin Hutchinson, Amy Deng, Xiang Liu, Chenwei Horner, Marie-Josephe Cullen, Michael Epstein, Caroline G Burdett, Laurie Dean, Michael C Chatterjee, Nilanjan Sampson, Joshua Chung, Charles C Kovaks, Joseph Gapstur, Susan M Stevens, Victoria L Teras, Lauren T Gaudet, Mia M Albanes, Demetrius Weinstein, Stephanie J Virtamo, Jarmo Taylor, Philip R Freedman, Neal D Abnet, Christian C Goldstein, Alisa M Hu, Nan Yu, Kai Yuan, Jian-Min Liao, Linda Ding, Ti Qiao, You-Lin Gao, Yu-Tang Koh, Woon-Puay Xiang, Yong-Bing Tang, Ze-Zhong Fan, Jin-Hu Aldrich, Melinda C Amos, Christopher Blot, William J Bock, Cathryn H Gillanders, Elizabeth M Harris, Curtis C Haiman, Christopher A Henderson, Brian E Kolonel, Laurence N Le Marchand, Loic McNeill, Lorna H Rybicki, Benjamin A Schwartz, Ann G Signorello, Lisa B Spitz, Margaret R Wiencke, John K Wrensch, Margaret Wu, Xifeng Zanetti, Krista A Ziegler, Regina G Figueroa, Jonine D Garcia-Closas, Montserrat Malats, Nuria Marenne, Gaelle Prokunina-Olsson, Ludmila Baris, Dalsu Schwenn, Molly Johnson, Alison Landi, Maria Teresa Goldin, Lynn Consonni, Dario Bertazzi, Pier Alberto Rotunno, Melissa Rajaraman, Preetha Andersson, Ulrika Freeman, Laura E Beane Berg, Christine D Buring, Julie E Butler, Mary A Carreon, Tania Feychting, Maria Ahlbom, Anders Gaziano, J Michael Giles, Graham G Hallmans, Goran Hankinson, Susan E Hartge, Patricia Henriksson, Roger Inskip, Peter D Johansen, Christoffer Landgren, Annelie McKean-Cowdin, Roberta Michaud, Dominique S Melin, Beatrice S Peters, Ulrike Ruder, Avima M Sesso, Howard D Severi, Gianluca Shu, Xiao-Ou Visvanathan, Kala White, Emily Wolk, Alicja Zeleniuch-Jacquotte, Anne Zheng, Wei Silverman, Debra T Kogevinas, Manolis Gonzalez, Juan R Villa, Olaya Li, Donghui Duell, Eric J Risch, Harvey A Olson, Sara H Kooperberg, Charles Wolpin, Brian M Jiao, Li Hassan, Manal Wheeler, William Arslan, Alan A Bas Bueno-de-Mesquita, H Fuchs, Charles S Gallinger, Steven Gross, Myron D Holly, Elizabeth A Klein, Alison P LaCroix, Andrea Mandelson, Margaret T Petersen, Gloria Boutron-Ruault, Marie-Christine Bracci, Paige M Canzian, Federico Chang, Kenneth Cotterchio, Michelle Giovannucci, Edward L Goggins, Michael Bolton, Judith A Hoffman Jenab, Mazda Khaw, Kay-Tee Krogh, Vittorio Kurtz, Robert C McWilliams, Robert R Mendelsohn, Julie B Rabe, Kari G Riboli, Elio Tjønneland, Anne Tobias, Geoffrey S Trichopoulos, Dimitrios Elena, Joanne W Yu, Herbert Amundadottir, Laufey Stolzenberg-Solomon, Rachael Z Kraft, Peter Schumacher, Fredrick Stram, Daniel Savage, Sharon A Mirabello, Lisa Andrulis, Irene L Wunder, Jay S García, Ana Patiño Sierrasesúmaga, Luis Barkauskas, Donald A Gorlick, Richard G Purdue, Mark Chow, Wong-Ho Moore, Lee E Schwartz, Kendra L Davis, Faith G Hsing, Ann W Berndt, Sonja I Black, Amanda Wentzensen, Nicolas Brinton, Louise A Lissowska, Jolanta Peplonska, Beata McGlynn, Katherine A Cook, Michael B Graubard, Barry I Kratz, Christian P Greene, Mark H Erickson, Ralph L Hunter, David J Thomas, Gilles Hoover, Robert N Real, Francisco X Fraumeni, Joseph F Caporaso, Neil E Tucker, Margaret Rothman, Nathaniel Pérez-Jurado, Luis A Chanock, Stephen J Detectable clonal mosaicism and its relationship to aging and cancer |
title | Detectable clonal mosaicism and its relationship to aging and cancer |
title_full | Detectable clonal mosaicism and its relationship to aging and cancer |
title_fullStr | Detectable clonal mosaicism and its relationship to aging and cancer |
title_full_unstemmed | Detectable clonal mosaicism and its relationship to aging and cancer |
title_short | Detectable clonal mosaicism and its relationship to aging and cancer |
title_sort | detectable clonal mosaicism and its relationship to aging and cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372921/ https://www.ncbi.nlm.nih.gov/pubmed/22561519 http://dx.doi.org/10.1038/ng.2270 |
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detectableclonalmosaicismanditsrelationshiptoagingandcancer AT wolkalicja detectableclonalmosaicismanditsrelationshiptoagingandcancer AT zeleniuchjacquotteanne detectableclonalmosaicismanditsrelationshiptoagingandcancer AT zhengwei detectableclonalmosaicismanditsrelationshiptoagingandcancer AT silvermandebrat detectableclonalmosaicismanditsrelationshiptoagingandcancer AT kogevinasmanolis detectableclonalmosaicismanditsrelationshiptoagingandcancer AT gonzalezjuanr detectableclonalmosaicismanditsrelationshiptoagingandcancer AT villaolaya detectableclonalmosaicismanditsrelationshiptoagingandcancer AT lidonghui detectableclonalmosaicismanditsrelationshiptoagingandcancer AT duellericj detectableclonalmosaicismanditsrelationshiptoagingandcancer AT rischharveya detectableclonalmosaicismanditsrelationshiptoagingandcancer AT olsonsarah detectableclonalmosaicismanditsrelationshiptoagingandcancer AT kooperbergcharles detectableclonalmosaicismanditsrelationshiptoagingandcancer AT wolpinbrianm detectableclonalmosaicismanditsrelationshiptoagingandcancer AT jiaoli detectableclonalmosaicismanditsrelationshiptoagingandcancer AT hassanmanal detectableclonalmosaicismanditsrelationshiptoagingandcancer AT wheelerwilliam detectableclonalmosaicismanditsrelationshiptoagingandcancer AT arslanalana detectableclonalmosaicismanditsrelationshiptoagingandcancer AT basbuenodemesquitah detectableclonalmosaicismanditsrelationshiptoagingandcancer AT fuchscharless detectableclonalmosaicismanditsrelationshiptoagingandcancer AT gallingersteven detectableclonalmosaicismanditsrelationshiptoagingandcancer AT grossmyrond detectableclonalmosaicismanditsrelationshiptoagingandcancer AT hollyelizabetha detectableclonalmosaicismanditsrelationshiptoagingandcancer AT kleinalisonp detectableclonalmosaicismanditsrelationshiptoagingandcancer AT lacroixandrea detectableclonalmosaicismanditsrelationshiptoagingandcancer AT mandelsonmargarett detectableclonalmosaicismanditsrelationshiptoagingandcancer AT petersengloria detectableclonalmosaicismanditsrelationshiptoagingandcancer AT boutronruaultmariechristine detectableclonalmosaicismanditsrelationshiptoagingandcancer AT braccipaigem detectableclonalmosaicismanditsrelationshiptoagingandcancer AT canzianfederico detectableclonalmosaicismanditsrelationshiptoagingandcancer AT changkenneth detectableclonalmosaicismanditsrelationshiptoagingandcancer AT cotterchiomichelle detectableclonalmosaicismanditsrelationshiptoagingandcancer AT giovannucciedwardl detectableclonalmosaicismanditsrelationshiptoagingandcancer AT gogginsmichael detectableclonalmosaicismanditsrelationshiptoagingandcancer AT boltonjudithahoffman detectableclonalmosaicismanditsrelationshiptoagingandcancer AT jenabmazda detectableclonalmosaicismanditsrelationshiptoagingandcancer AT khawkaytee detectableclonalmosaicismanditsrelationshiptoagingandcancer AT kroghvittorio detectableclonalmosaicismanditsrelationshiptoagingandcancer AT kurtzrobertc detectableclonalmosaicismanditsrelationshiptoagingandcancer AT mcwilliamsrobertr detectableclonalmosaicismanditsrelationshiptoagingandcancer AT mendelsohnjulieb detectableclonalmosaicismanditsrelationshiptoagingandcancer AT rabekarig detectableclonalmosaicismanditsrelationshiptoagingandcancer AT ribolielio detectableclonalmosaicismanditsrelationshiptoagingandcancer AT tjønnelandanne detectableclonalmosaicismanditsrelationshiptoagingandcancer AT tobiasgeoffreys detectableclonalmosaicismanditsrelationshiptoagingandcancer AT trichopoulosdimitrios detectableclonalmosaicismanditsrelationshiptoagingandcancer AT elenajoannew detectableclonalmosaicismanditsrelationshiptoagingandcancer AT yuherbert detectableclonalmosaicismanditsrelationshiptoagingandcancer AT amundadottirlaufey detectableclonalmosaicismanditsrelationshiptoagingandcancer AT stolzenbergsolomonrachaelz detectableclonalmosaicismanditsrelationshiptoagingandcancer AT kraftpeter detectableclonalmosaicismanditsrelationshiptoagingandcancer AT schumacherfredrick detectableclonalmosaicismanditsrelationshiptoagingandcancer AT stramdaniel detectableclonalmosaicismanditsrelationshiptoagingandcancer AT savagesharona detectableclonalmosaicismanditsrelationshiptoagingandcancer AT mirabellolisa detectableclonalmosaicismanditsrelationshiptoagingandcancer AT andrulisirenel detectableclonalmosaicismanditsrelationshiptoagingandcancer AT wunderjays detectableclonalmosaicismanditsrelationshiptoagingandcancer AT garciaanapatino detectableclonalmosaicismanditsrelationshiptoagingandcancer AT sierrasesumagaluis detectableclonalmosaicismanditsrelationshiptoagingandcancer AT barkauskasdonalda detectableclonalmosaicismanditsrelationshiptoagingandcancer AT gorlickrichardg detectableclonalmosaicismanditsrelationshiptoagingandcancer AT purduemark detectableclonalmosaicismanditsrelationshiptoagingandcancer AT chowwongho detectableclonalmosaicismanditsrelationshiptoagingandcancer AT mooreleee detectableclonalmosaicismanditsrelationshiptoagingandcancer AT schwartzkendral detectableclonalmosaicismanditsrelationshiptoagingandcancer AT davisfaithg detectableclonalmosaicismanditsrelationshiptoagingandcancer AT hsingannw detectableclonalmosaicismanditsrelationshiptoagingandcancer AT berndtsonjai detectableclonalmosaicismanditsrelationshiptoagingandcancer AT blackamanda detectableclonalmosaicismanditsrelationshiptoagingandcancer AT wentzensennicolas detectableclonalmosaicismanditsrelationshiptoagingandcancer AT brintonlouisea detectableclonalmosaicismanditsrelationshiptoagingandcancer AT lissowskajolanta detectableclonalmosaicismanditsrelationshiptoagingandcancer AT peplonskabeata detectableclonalmosaicismanditsrelationshiptoagingandcancer AT mcglynnkatherinea detectableclonalmosaicismanditsrelationshiptoagingandcancer AT cookmichaelb detectableclonalmosaicismanditsrelationshiptoagingandcancer AT graubardbarryi detectableclonalmosaicismanditsrelationshiptoagingandcancer AT kratzchristianp detectableclonalmosaicismanditsrelationshiptoagingandcancer AT greenemarkh detectableclonalmosaicismanditsrelationshiptoagingandcancer AT ericksonralphl detectableclonalmosaicismanditsrelationshiptoagingandcancer AT hunterdavidj detectableclonalmosaicismanditsrelationshiptoagingandcancer AT thomasgilles detectableclonalmosaicismanditsrelationshiptoagingandcancer AT hooverrobertn detectableclonalmosaicismanditsrelationshiptoagingandcancer AT realfranciscox detectableclonalmosaicismanditsrelationshiptoagingandcancer AT fraumenijosephf detectableclonalmosaicismanditsrelationshiptoagingandcancer AT caporasoneile detectableclonalmosaicismanditsrelationshiptoagingandcancer AT tuckermargaret detectableclonalmosaicismanditsrelationshiptoagingandcancer AT rothmannathaniel detectableclonalmosaicismanditsrelationshiptoagingandcancer AT perezjuradoluisa detectableclonalmosaicismanditsrelationshiptoagingandcancer AT chanockstephenj detectableclonalmosaicismanditsrelationshiptoagingandcancer |