Severe Community-acquired Pneumonia Due to Staphylococcus aureus, 2003–04 Influenza Season

During the 2003–04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk...

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Detalles Bibliográficos
Autores principales: Hageman, Jeffrey C., Uyeki, Timothy M., Francis, John S., Jernigan, Daniel B., Wheeler, J. Gary, Bridges, Carolyn B., Barenkamp, Stephen J., Sievert, Dawn M., Srinivasan, Arjun, Doherty, Meg C., McDougal, Linda K., Killgore, George E., Lopatin, Uri A., Coffman, Rebecca, MacDonald, J. Kathryn, McAllister, Sigrid K., Fosheim, Gregory E., Patel, Jean B., McDonald, L. Clifford
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373026/
https://www.ncbi.nlm.nih.gov/pubmed/16707043
http://dx.doi.org/10.3201/eid1206.051141
Descripción
Sumario:During the 2003–04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk factors for MRSA. Twelve (71%) had laboratory evidence of influenza virus infection. All but 1 patient, who died on arrival, were hospitalized. Death occurred in 5 (4 with MRSA). S. aureus isolates were available from 13 (76%) patients (11 MRSA). Toxin genes were detected in all isolates; 11 (85%) had only genes for Panton-Valentine leukocidin. All isolates had community-associated pulsed-field gel electrophoresis patterns; all MRSA isolates had the staphylococcal cassette chromosome mec type IVa. In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA.

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