Cargando…

Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer's Disease

Alzheimer's disease (AD) is the most common form of dementia found in all human populations worldwide, while vascular dementia (VaD) is the second most common form of dementia. New biomarkers for early and specific diagnosis of AD and VaD are needed to achieve greater insight into changes occur...

Descripción completa

Detalles Bibliográficos
Autores principales: Simonsen, A. H., Hagnelius, N.-O., Waldemar, G., Nilsson, T. K., McGuire, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373063/
https://www.ncbi.nlm.nih.gov/pubmed/22701795
http://dx.doi.org/10.1155/2012/824024
_version_ 1782235403858739200
author Simonsen, A. H.
Hagnelius, N.-O.
Waldemar, G.
Nilsson, T. K.
McGuire, J.
author_facet Simonsen, A. H.
Hagnelius, N.-O.
Waldemar, G.
Nilsson, T. K.
McGuire, J.
author_sort Simonsen, A. H.
collection PubMed
description Alzheimer's disease (AD) is the most common form of dementia found in all human populations worldwide, while vascular dementia (VaD) is the second most common form of dementia. New biomarkers for early and specific diagnosis of AD and VaD are needed to achieve greater insight into changes occurring in the brain and direct therapeutic strategies. The objective of this explorative study was to discover candidate protein biomarkers for the differential diagnosis between VaD and AD. Surface-enhanced laser desorption/ionization (SELDI) TOF-MS was used to differentially profile proteins and peptides in CSF samples from 28 AD patients and 21 patients with VaD. A combination of univariate (Kruskal-Wallis) and multivariate (independent component analysis) statistical approaches produced a list of 27 proteins and peptides that could differentiate between VaD and AD. These markers represent various physiological processes, such as protein degradation (ubiquitin), protease inhibition (cystatin C and alpha-1-antichymoptrypsin), and inflammation (C3a and C4a) that are known to be represented in neurodegenerative diseases.
format Online
Article
Text
id pubmed-3373063
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-33730632012-06-14 Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer's Disease Simonsen, A. H. Hagnelius, N.-O. Waldemar, G. Nilsson, T. K. McGuire, J. Int J Proteomics Research Article Alzheimer's disease (AD) is the most common form of dementia found in all human populations worldwide, while vascular dementia (VaD) is the second most common form of dementia. New biomarkers for early and specific diagnosis of AD and VaD are needed to achieve greater insight into changes occurring in the brain and direct therapeutic strategies. The objective of this explorative study was to discover candidate protein biomarkers for the differential diagnosis between VaD and AD. Surface-enhanced laser desorption/ionization (SELDI) TOF-MS was used to differentially profile proteins and peptides in CSF samples from 28 AD patients and 21 patients with VaD. A combination of univariate (Kruskal-Wallis) and multivariate (independent component analysis) statistical approaches produced a list of 27 proteins and peptides that could differentiate between VaD and AD. These markers represent various physiological processes, such as protein degradation (ubiquitin), protease inhibition (cystatin C and alpha-1-antichymoptrypsin), and inflammation (C3a and C4a) that are known to be represented in neurodegenerative diseases. Hindawi Publishing Corporation 2012 2012-06-04 /pmc/articles/PMC3373063/ /pubmed/22701795 http://dx.doi.org/10.1155/2012/824024 Text en Copyright © 2012 A. H. Simonsen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Simonsen, A. H.
Hagnelius, N.-O.
Waldemar, G.
Nilsson, T. K.
McGuire, J.
Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer's Disease
title Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer's Disease
title_full Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer's Disease
title_fullStr Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer's Disease
title_full_unstemmed Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer's Disease
title_short Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer's Disease
title_sort protein markers for the differential diagnosis of vascular dementia and alzheimer's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373063/
https://www.ncbi.nlm.nih.gov/pubmed/22701795
http://dx.doi.org/10.1155/2012/824024
work_keys_str_mv AT simonsenah proteinmarkersforthedifferentialdiagnosisofvasculardementiaandalzheimersdisease
AT hagneliusno proteinmarkersforthedifferentialdiagnosisofvasculardementiaandalzheimersdisease
AT waldemarg proteinmarkersforthedifferentialdiagnosisofvasculardementiaandalzheimersdisease
AT nilssontk proteinmarkersforthedifferentialdiagnosisofvasculardementiaandalzheimersdisease
AT mcguirej proteinmarkersforthedifferentialdiagnosisofvasculardementiaandalzheimersdisease