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Metabolic Disorders and Steatosis in Patients with Chronic Hepatitis C: Metabolic Strategies for Antiviral Treatments
It has been reported that hepatitis C virus (HCV) infection is closely associated with hepatic metabolic disorders. Hepatic steatosis and insulin resistance are both relatively common in patients with chronic hepatitis C. Recent investigations suggest that HCV infection changes the expression profil...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373124/ https://www.ncbi.nlm.nih.gov/pubmed/22701799 http://dx.doi.org/10.1155/2012/264017 |
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author | Enjoji, Munechika Kohjima, Motoyuki Kotoh, Kazuhiro Nakamuta, Makoto |
author_facet | Enjoji, Munechika Kohjima, Motoyuki Kotoh, Kazuhiro Nakamuta, Makoto |
author_sort | Enjoji, Munechika |
collection | PubMed |
description | It has been reported that hepatitis C virus (HCV) infection is closely associated with hepatic metabolic disorders. Hepatic steatosis and insulin resistance are both relatively common in patients with chronic hepatitis C. Recent investigations suggest that HCV infection changes the expression profile of lipid-metabolism-associated factors in the liver, conferring advantages to the life cycle of HCV. Moreover, insulin resistance and steatosis are independent predictors of impaired response to antiviral treatment in chronic hepatitis C. In this paper, we summarize our current knowledge of hepatic metabolic disorders and describe how HCV leads to and exploits these hepatic disorders. We also discuss the clinical significance of insulin sensitizers used to improve insulin resistance and lipid modulators used to manage lipid metabolism as potential treatment options for chronic hepatitis C. |
format | Online Article Text |
id | pubmed-3373124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33731242012-06-14 Metabolic Disorders and Steatosis in Patients with Chronic Hepatitis C: Metabolic Strategies for Antiviral Treatments Enjoji, Munechika Kohjima, Motoyuki Kotoh, Kazuhiro Nakamuta, Makoto Int J Hepatol Review Article It has been reported that hepatitis C virus (HCV) infection is closely associated with hepatic metabolic disorders. Hepatic steatosis and insulin resistance are both relatively common in patients with chronic hepatitis C. Recent investigations suggest that HCV infection changes the expression profile of lipid-metabolism-associated factors in the liver, conferring advantages to the life cycle of HCV. Moreover, insulin resistance and steatosis are independent predictors of impaired response to antiviral treatment in chronic hepatitis C. In this paper, we summarize our current knowledge of hepatic metabolic disorders and describe how HCV leads to and exploits these hepatic disorders. We also discuss the clinical significance of insulin sensitizers used to improve insulin resistance and lipid modulators used to manage lipid metabolism as potential treatment options for chronic hepatitis C. Hindawi Publishing Corporation 2012 2012-06-04 /pmc/articles/PMC3373124/ /pubmed/22701799 http://dx.doi.org/10.1155/2012/264017 Text en Copyright © 2012 Munechika Enjoji et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Enjoji, Munechika Kohjima, Motoyuki Kotoh, Kazuhiro Nakamuta, Makoto Metabolic Disorders and Steatosis in Patients with Chronic Hepatitis C: Metabolic Strategies for Antiviral Treatments |
title | Metabolic Disorders and Steatosis in Patients with Chronic Hepatitis C: Metabolic Strategies for Antiviral Treatments |
title_full | Metabolic Disorders and Steatosis in Patients with Chronic Hepatitis C: Metabolic Strategies for Antiviral Treatments |
title_fullStr | Metabolic Disorders and Steatosis in Patients with Chronic Hepatitis C: Metabolic Strategies for Antiviral Treatments |
title_full_unstemmed | Metabolic Disorders and Steatosis in Patients with Chronic Hepatitis C: Metabolic Strategies for Antiviral Treatments |
title_short | Metabolic Disorders and Steatosis in Patients with Chronic Hepatitis C: Metabolic Strategies for Antiviral Treatments |
title_sort | metabolic disorders and steatosis in patients with chronic hepatitis c: metabolic strategies for antiviral treatments |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373124/ https://www.ncbi.nlm.nih.gov/pubmed/22701799 http://dx.doi.org/10.1155/2012/264017 |
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