Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease

Synapse abnormalities in Huntington's disease (HD) patients can precede clinical diagnosis and neuron loss by decades. The polyglutamine expansion in the huntingtin (htt) protein that underlies this disorder leads to perturbations in many cellular pathways, including the disruption of Rab11-dep...

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Detalles Bibliográficos
Autores principales: Steinert, Joern R., Campesan, Susanna, Richards, Paul, Kyriacou, Charalambos P., Forsythe, Ian D., Giorgini, Flaviano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373239/
https://www.ncbi.nlm.nih.gov/pubmed/22466800
http://dx.doi.org/10.1093/hmg/dds117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373239/
https://www.ncbi.nlm.nih.gov/pubmed/22466800
http://dx.doi.org/10.1093/hmg/dds117

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