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Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation

The abnormal accumulation of the microtubule-binding protein tau is associated with a number of neurodegenerative conditions, and correlates with cognitive decline in Alzheimer's disease. The ubiquitin ligase carboxy terminus of Hsp70-interacting protein (CHIP) and the molecular chaperone Hsp90...

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Detalles Bibliográficos
Autores principales:	Cook, Casey, Gendron, Tania F., Scheffel, Kristyn, Carlomagno, Yari, Dunmore, Judy, DeTure, Michael, Petrucelli, Leonard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373241/ https://www.ncbi.nlm.nih.gov/pubmed/22492994 http://dx.doi.org/10.1093/hmg/dds125

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