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Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs

BACKGROUND: Multidrug resistance, a major impediment to successful cancer chemotherapy, is the result of overexpression of ATP-binding cassette (ABC) transporters extruding internalized drugs. Silencing of ABC transporter gene expression with small interfering RNA (siRNA) could be an attractive appr...

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Detalles Bibliográficos
Autores principales:	Li, Yong Tsuey, Chua, Ming Jang, Kunnath, Anil Philip, Chowdhury, Ezharul Hoque
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373294/ https://www.ncbi.nlm.nih.gov/pubmed/22701315 http://dx.doi.org/10.2147/IJN.S30500

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