The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking

Two intraflagellar transport (IFT) complexes, IFT-A and IFT-B, build and maintain primary cilia and are required for activity of the Sonic hedgehog (Shh) pathway. A weak allele of the IFT-A gene, Ift144, caused subtle defects in cilia structure and ectopic activation of the Shh pathway. In contrast,...

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Detalles Bibliográficos
Autores principales: Liem, Karel F., Ashe, Alyson, He, Mu, Satir, Peter, Moran, Jennifer, Beier, David, Wicking, Carol, Anderson, Kathryn V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373400/
https://www.ncbi.nlm.nih.gov/pubmed/22689656
http://dx.doi.org/10.1083/jcb.201110049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373400/
https://www.ncbi.nlm.nih.gov/pubmed/22689656
http://dx.doi.org/10.1083/jcb.201110049

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