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Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase

Little is known about quality control of proteins that aberrantly or persistently engage the endoplasmic reticulum (ER)-localized translocon en route to membrane localization or the secretory pathway. Hrd1 and Doa10, the primary ubiquitin ligases that function in ER-associated degradation (ERAD) in...

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Detalles Bibliográficos
Autores principales:	Rubenstein, Eric M., Kreft, Stefan G., Greenblatt, Wesley, Swanson, Robert, Hochstrasser, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373407/ https://www.ncbi.nlm.nih.gov/pubmed/22689655 http://dx.doi.org/10.1083/jcb.201203061

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