Circulating DNA: Diagnostic Tool and Predictive Marker for Overall Survival of NSCLC Patients

PURPOSE: The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease. METHODS: We conducted a study of 309 individuals and the cDNA levels were as...

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Autores principales: Catarino, Raquel, Coelho, Ana, Araújo, António, Gomes, Mónica, Nogueira, Augusto, Lopes, Carlos, Medeiros, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373551/
https://www.ncbi.nlm.nih.gov/pubmed/22701665
http://dx.doi.org/10.1371/journal.pone.0038559
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author Catarino, Raquel
Coelho, Ana
Araújo, António
Gomes, Mónica
Nogueira, Augusto
Lopes, Carlos
Medeiros, Rui
author_facet Catarino, Raquel
Coelho, Ana
Araújo, António
Gomes, Mónica
Nogueira, Augusto
Lopes, Carlos
Medeiros, Rui
author_sort Catarino, Raquel
collection PubMed
description PURPOSE: The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease. METHODS: We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology. RESULTS: We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations. CONCLUSIONS: Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability.
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spelling pubmed-33735512012-06-14 Circulating DNA: Diagnostic Tool and Predictive Marker for Overall Survival of NSCLC Patients Catarino, Raquel Coelho, Ana Araújo, António Gomes, Mónica Nogueira, Augusto Lopes, Carlos Medeiros, Rui PLoS One Research Article PURPOSE: The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease. METHODS: We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology. RESULTS: We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations. CONCLUSIONS: Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability. Public Library of Science 2012-06-12 /pmc/articles/PMC3373551/ /pubmed/22701665 http://dx.doi.org/10.1371/journal.pone.0038559 Text en Catarino et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Catarino, Raquel
Coelho, Ana
Araújo, António
Gomes, Mónica
Nogueira, Augusto
Lopes, Carlos
Medeiros, Rui
Circulating DNA: Diagnostic Tool and Predictive Marker for Overall Survival of NSCLC Patients
title Circulating DNA: Diagnostic Tool and Predictive Marker for Overall Survival of NSCLC Patients
title_full Circulating DNA: Diagnostic Tool and Predictive Marker for Overall Survival of NSCLC Patients
title_fullStr Circulating DNA: Diagnostic Tool and Predictive Marker for Overall Survival of NSCLC Patients
title_full_unstemmed Circulating DNA: Diagnostic Tool and Predictive Marker for Overall Survival of NSCLC Patients
title_short Circulating DNA: Diagnostic Tool and Predictive Marker for Overall Survival of NSCLC Patients
title_sort circulating dna: diagnostic tool and predictive marker for overall survival of nsclc patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373551/
https://www.ncbi.nlm.nih.gov/pubmed/22701665
http://dx.doi.org/10.1371/journal.pone.0038559
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