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Regulation of RasGRP1 Function in T Cell Development and Activation by Its Unique Tail Domain

The Ras-guanyl nucleotide exchange factor RasGRP1 plays a critical role in T cell receptor-mediated Erk activation. Previous studies have emphasized the importance of RasGRP1 in the positive selection of thymocytes, activation of T cells, and control of autoimmunity. RasGRP1 consists of a number of...

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Detalles Bibliográficos
Autores principales:	Fuller, Deirdre M., Zhu, Minghua, Song, Xiaohua, Ou-Yang, Chih-wen, Sullivan, Sarah A., Stone, James C., Zhang, Weiguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373593/ https://www.ncbi.nlm.nih.gov/pubmed/22719950 http://dx.doi.org/10.1371/journal.pone.0038796

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