Cargando…

A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway

Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic reticulum (ER) stress leads to apoptosis through the upregulation of a subset of pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zamorano, Sebastián, Rojas-Rivera, Diego, Lisbona, Fernanda, Parra, Valentina, Court, Felipe A., Villegas, Rosario, Cheng, Emily H., Korsmeyer, Stanley J., Lavandero, Sergio, Hetz, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373601/ https://www.ncbi.nlm.nih.gov/pubmed/22719850 http://dx.doi.org/10.1371/journal.pone.0037782

Ejemplares similares

Paradoxical implication of BAX/BAK in the persistence of tetraploid cells
por: Deng, Jiayin, et al.
Publicado: (2021)

The great migration of Bax and Bak
por: Edlich, Frank
Publicado: (2015)

Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis
por: Quarato, Giovanni, et al.
Publicado: (2023)

Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis
por: Heimer, Sina, et al.
Publicado: (2019)

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target
por: Iyer, Sweta, et al.
Publicado: (2020)

Paclitaxel-Induced Apoptosis Is BAK-Dependent, but BAX and BIM-Independent in Breast Tumor
por: Miller, Anna V., et al.
Publicado: (2013)

Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK
por: Ke, F, et al.
Publicado: (2015)

Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK
por: McCoy, F, et al.
Publicado: (2010)

BH3 Peptides Induce Mitochondrial Fission and Cell Death Independent of BAX/BAK
por: Shroff, Emelyn H., et al.
Publicado: (2009)

Consequences of the combined loss of BOK and BAK or BOK and BAX
por: Ke, F, et al.
Publicado: (2013)

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax
por: Hockings, C, et al.
Publicado: (2015)

Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation
por: Shalaby, Raed, et al.
Publicado: (2022)

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
por: Zong, Wei-Xing, et al.
Publicado: (2003)

Evaluation of Bax and Bak Gene Mutations and Expression in Breast Cancer
por: Kholoussi, Naglaa Mohamed, et al.
Publicado: (2014)

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
por: Iyer, Sweta, et al.
Publicado: (2016)

Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells
por: Leanza, Luigi, et al.
Publicado: (2012)

MCL-1ES Induces MCL-1L-Dependent BAX- and BAK-Independent Mitochondrial Apoptosis
por: Kim, Jae-Hong, et al.
Publicado: (2013)

Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis
por: Nechushtan, Amotz, et al.
Publicado: (2001)

Brain and Testicular Tumors in Mice with Progenitor Cells Lacking BAX and BAK
por: Katz, Samuel G., et al.
Publicado: (2012)

Bax/Bak activation in the absence of Bid, Bim, Puma, and p53
por: Zhang, J, et al.
Publicado: (2016)

BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming
por: Kim, Esther J.Y., et al.
Publicado: (2018)

Regulated Targeting of BAX to Mitochondria
por: Goping, Ing Swie, et al.
Publicado: (1998)

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins
por: Goodall, Katharine J., et al.
Publicado: (2016)

The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer
por: Carberry, Steven, et al.
Publicado: (2018)

Ablation of Bax and Bak protects skeletal muscle against pressure-induced injury
por: Tam, Bjorn T., et al.
Publicado: (2018)

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
por: Karch, Jason, et al.
Publicado: (2017)

Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1
por: Dong, Li, et al.
Publicado: (2020)

Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function
por: Ferrer, Pedro Eitz, et al.
Publicado: (2012)

The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization
por: Zhou, Heng, et al.
Publicado: (2015)

Titanium Dioxide (TiO(2)) Nanoparticles Preferentially Induce Cell Death in Transformed Cells in a Bak/Bax-Independent Fashion
por: Zhu, Yanglong, et al.
Publicado: (2012)

Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner
por: Guo, W, et al.
Publicado: (2015)

BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy
por: Pedro, Jose Manuel Bravo-San, et al.
Publicado: (2015)

Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death
por: Miller, Timothy M., et al.
Publicado: (1997)

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane
por: O'Neill, Katelyn L., et al.
Publicado: (2016)

The third model of Bax/Bak activation: a Bcl-2 family feud finally resolved?
por: Luo, Xu, et al.
Publicado: (2020)

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death
por: Garciaz, Sylvain, et al.
Publicado: (2022)

Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak
por: Waguia Kontchou, Collins, et al.
Publicado: (2022)

Modeling apoptosis resistance in CHO cells with CRISPR‐mediated knockouts of Bak1, Bax, and Bok
por: MacDonald, Michael A., et al.
Publicado: (2022)

Study of the Bcl-2 Interactome by BiFC Reveals Differences in the Activation Mechanism of Bax and Bak
por: Gonzalo, Óscar, et al.
Publicado: (2023)

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis
por: Hutcheson, Jack, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_l9jgeu1mgioji4pg0cnse17gnq