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Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters

Despite much research, our understanding of the rules by which cis-regulatory sequences are translated into expression levels is still lacking. We devised a method for obtaining parallel and highly accurate expression measurements of thousands of fully designed promoters, and applied it to measure t...

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Detalles Bibliográficos
Autores principales: Sharon, Eilon, Kalma, Yael, Sharp, Ayala, Raveh-Sadka, Tali, Levo, Michal, Zeevi, Danny, Keren, Leeat, Yakhini, Zohar, Weinberger, Adina, Segal, Eran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374032/
https://www.ncbi.nlm.nih.gov/pubmed/22609971
http://dx.doi.org/10.1038/nbt.2205