Cargando…

A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease

The adiponutrin (PNPLA3) rs738409 polymorphism has been found to be associated with susceptibility to non-alcoholic fatty liver disease (NAFLD) in various cohorts. We further investigated the association of this polymorphism with non-alcoholic steatohepatitis (NASH) severity and with histological fe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zain, Shamsul Mohd, Mohamed, Rosmawati, Mahadeva, Sanjiv, Cheah, Phaik Leng, Rampal, Sanjay, Basu, Roma Choudhury, Mohamed, Zahurin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2012
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374090/ https://www.ncbi.nlm.nih.gov/pubmed/22258181 http://dx.doi.org/10.1007/s00439-012-1141-y

Ejemplares similares

Susceptibility and Gene Interaction Study of the Angiotensin II Type 1 Receptor (AGTR1) Gene Polymorphisms with Non-Alcoholic Fatty Liver Disease in a Multi-Ethnic Population
por: Zain, Shamsul Mohd, et al.
Publicado: (2013)

Genome-Wide Analysis of Copy Number Variation Identifies Candidate Gene Loci Associated with the Progression of Non-Alcoholic Fatty Liver Disease
por: Zain, Shamsul Mohd, et al.
Publicado: (2014)

Use of simple scoring systems for a public health approach in the management of non‐alcoholic fatty liver disease patients
por: Zain, Shamsul Mohd, et al.
Publicado: (2020)

Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non-alcoholic fatty liver disease
por: Zain, Shamsul Mohd, et al.
Publicado: (2015)

Ethnic Differences in the Prevalence of Metabolic Syndrome: Results from a Multi-Ethnic Population-Based Survey in Malaysia
por: Rampal, Sanjay, et al.
Publicado: (2012)

Loss-of-function HSD17B13 variants, non-alcoholic steatohepatitis and adverse liver outcomes: Results from a multi-ethnic Asian cohort
por: Ting, Yi-Wen, et al.
Publicado: (2021)

PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease
por: BasuRay, Soumik
Publicado: (2019)

Anthropometric, biochemical and clinical assessment of malnutrition in Malaysian patients with advanced cirrhosis
por: Tai, Mei-Ling S, et al.
Publicado: (2010)

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
por: BasuRay, Soumik, et al.
Publicado: (2017)

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
por: Romeo, Stefano, et al.
Publicado: (2008)

Analysis of serum circulating MicroRNAs level in Malaysian patients with gestational diabetes mellitus
por: Jamalpour, Sajad, et al.
Publicado: (2022)

Author Correction: Analysis of serum circulating MicroRNAs level in Malaysian patients with gestational diabetes mellitus
por: Jamalpour, Sajad, et al.
Publicado: (2023)

Determinants of High Fasting Insulin and Insulin Resistance Among Overweight/Obese Adolescents
por: Ling, Jerri Chiu Yun, et al.
Publicado: (2016)

PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver disease
por: Wang, Jin-Zhi, et al.
Publicado: (2018)

Association between the PNPLA3 I148M Polymorphism and Non-Alcoholic Fatty Liver Disease in the Uygur and Han Ethnic Groups of Northwestern China
por: Zhang, Yuexin, et al.
Publicado: (2014)

Circulating cytokines and small molecules follow distinct expression patterns in acute myeloid leukaemia
por: Islam, Mirazul, et al.
Publicado: (2017)

PNPLA3 GG Genotype and Carotid Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease
por: Petta, Salvatore, et al.
Publicado: (2013)

The PNPLA3 rs738409 Variant but not MBOAT7 rs641738 is a Risk Factor for Nonalcoholic Fatty Liver Disease in Obese U.S. Children of Hispanic Ethnicity
por: Mansoor, Sana, et al.
Publicado: (2021)

Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease
por: Hotta, Kikuko, et al.
Publicado: (2010)

PNPLA3 as a Genetic Determinant of Risk for and Severity of Non-alcoholic Fatty Liver Disease Spectrum
por: Salameh, Habeeb, et al.
Publicado: (2016)

Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans
por: Liu, Wanqing, et al.
Publicado: (2016)

PNPLA3 and TM6SF2 polymorphisms in Brazilian patients with nonalcoholic fatty liver disease
por: Lisboa, Quelson Coelho, et al.
Publicado: (2020)

Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
por: Smagris, Eriks, et al.
Publicado: (2015)

Kombiglyze (metformin and saxagliptin)‐induced hepatotoxicity in a patient with non‐alcoholic fatty liver disease
por: Thalha, Abdul Malik, et al.
Publicado: (2018)

Genetic Variants in PNPLA3 and Risk of Non-Alcoholic Fatty Liver Disease in a Han Chinese Population
por: Peng, Xian-E, et al.
Publicado: (2012)

SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy
por: Kim, Kwang-Youn, et al.
Publicado: (2016)

Genetic Polymorphisms of PNPLA3 and SAMM50 Are Associated with Nonalcoholic Fatty Liver Disease in a Korean Population
por: Chung, Goh Eun, et al.
Publicado: (2018)

PNPLA3 rs139051 is associated with phospholipid metabolite profile and hepatic inflammation in nonalcoholic fatty liver disease
por: Luo, Ji-Jun, et al.
Publicado: (2018)

PNPLA3 Expression Is Related to Liver Steatosis in Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease
por: Aragonès, Gemma, et al.
Publicado: (2016)

Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease
por: Razlan, Hamizah, et al.
Publicado: (2011)

Synergistic Associations of PNPLA3 I148M Variant, Alcohol Intake, and Obesity With Risk of Cirrhosis, Hepatocellular Carcinoma, and Mortality
por: Kim, Hyun-seok, et al.
Publicado: (2022)

Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease
por: Huang, Yongcheng, et al.
Publicado: (2011)

Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese
por: Kawaguchi, Takahisa, et al.
Publicado: (2012)

Corrigendum: SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy
por: Kim, Kwang-Youn, et al.
Publicado: (2016)

Effect of Gut Microbiota and PNPLA3 rs738409 Variant on Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Youth
por: Monga Kravetz, Ayesha, et al.
Publicado: (2020)

Mitochondrial haplogroup G is associated with nonalcoholic fatty liver disease, while haplogroup A mitigates the effects of PNPLA3
por: Gusdon, Aaron M., et al.
Publicado: (2020)

PNPLA3 and SERPINA1 Variants Are Associated with Severity of Fatty Liver Disease at First Referral to a Tertiary Center
por: Semmler, Georg, et al.
Publicado: (2021)

The role of PNPLA3 (rs738409) c>g variant on histological progression of non-alcoholic fatty liver disease
por: Idilman, Ramazan, et al.
Publicado: (2020)

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics
por: Sherman, David J., et al.
Publicado: (2023)

Association between non‐alcoholic fatty liver disease evaluated by transient elastography with extracranial carotid atherosclerosis in a multiethnic Asian community
por: Tan, Eugene Choon‐Li, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lfi05hhvojsbk172ucsoml5pu2