Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss

BACKGROUND: Fibrinogen/LDL apheresis has been proven to be effective in treatment of sudden sensorineural hearing loss (SSNH). This study is aimed to investigate if reduction of fibrinogen and serum LDL is also effective in patients with SSNH non-responding toward treatment with corticosteroids and...

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Detalles Bibliográficos
Autores principales: Canis, Martin, Heigl, Franz, Suckfuell, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374113/
https://www.ncbi.nlm.nih.gov/pubmed/22528132
http://dx.doi.org/10.1007/s11789-012-0044-8
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author Canis, Martin
Heigl, Franz
Suckfuell, Markus
author_facet Canis, Martin
Heigl, Franz
Suckfuell, Markus
author_sort Canis, Martin
collection PubMed
description BACKGROUND: Fibrinogen/LDL apheresis has been proven to be effective in treatment of sudden sensorineural hearing loss (SSNH). This study is aimed to investigate if reduction of fibrinogen and serum LDL is also effective in patients with SSNH non-responding toward treatment with corticosteroids and plasmaexpanders. METHODS: Remission rates of 217 patients suffering from SSHL were investigated after treatment with apheresis. All patients were non-responders after other therapies such as high doses of steroids or plasmaexpanders. RESULTS: Single apheresis resulted in complete or partial remissions in 61% of patients when given after other unsuccessful conducted therapies such as corticosteroids and plasmaexpanders. CONCLUSION: Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss even after unsuccessful other therapies.
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spelling pubmed-33741132012-06-14 Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss Canis, Martin Heigl, Franz Suckfuell, Markus Clin Res Cardiol Suppl Article BACKGROUND: Fibrinogen/LDL apheresis has been proven to be effective in treatment of sudden sensorineural hearing loss (SSNH). This study is aimed to investigate if reduction of fibrinogen and serum LDL is also effective in patients with SSNH non-responding toward treatment with corticosteroids and plasmaexpanders. METHODS: Remission rates of 217 patients suffering from SSHL were investigated after treatment with apheresis. All patients were non-responders after other therapies such as high doses of steroids or plasmaexpanders. RESULTS: Single apheresis resulted in complete or partial remissions in 61% of patients when given after other unsuccessful conducted therapies such as corticosteroids and plasmaexpanders. CONCLUSION: Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss even after unsuccessful other therapies. Springer-Verlag 2012-02-28 2012-06 /pmc/articles/PMC3374113/ /pubmed/22528132 http://dx.doi.org/10.1007/s11789-012-0044-8 Text en © The Author(s) 2012
spellingShingle Article
Canis, Martin
Heigl, Franz
Suckfuell, Markus
Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss
title Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss
title_full Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss
title_fullStr Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss
title_full_unstemmed Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss
title_short Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss
title_sort fibrinogen/ldl apheresis is a promising rescue therapy for sudden sensorineural hearing loss
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374113/
https://www.ncbi.nlm.nih.gov/pubmed/22528132
http://dx.doi.org/10.1007/s11789-012-0044-8
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AT suckfuellmarkus fibrinogenldlapheresisisapromisingrescuetherapyforsuddensensorineuralhearingloss

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