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Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry

Genetic variation on the Y chromosome has not been convincingly implicated in prostate cancer risk. To comprehensively analyze the role of inherited Y chromosome variation in prostate cancer risk in individuals of European ancestry, we genotyped 34 binary Y chromosome markers in 3,995 prostate cance...

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Autores principales: Wang, Zhaoming, Parikh, Hemang, Jia, Jinping, Myers, Timothy, Yeager, Meredith, Jacobs, Kevin B., Hutchinson, Amy, Burdett, Laurie, Ghosh, Arpita, Thun, Michael J., Gapstur, Susan M., Ryan Diver, W., Virtamo, Jarmo, Albanes, Demetrius, Cancel-Tassin, Geraldine, Valeri, Antoine, Cussenot, Olivier, Offit, Kenneth, Giovannucci, Ed, Ma, Jing, Stampfer, Meir J., Michael Gaziano, J., Hunter, David J., Dutra-Clarke, Ana, Kirchhoff, Tomas, Alavanja, Michael, Freeman, Laura B., Koutros, Stella, Hoover, Robert, Berndt, Sonja I., Hayes, Richard B., Agalliu, Ilir, Burk, Robert D., Wacholder, Sholom, Thomas, Gilles, Amundadottir, Laufey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374121/
https://www.ncbi.nlm.nih.gov/pubmed/22271044
http://dx.doi.org/10.1007/s00439-012-1139-5
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author Wang, Zhaoming
Parikh, Hemang
Jia, Jinping
Myers, Timothy
Yeager, Meredith
Jacobs, Kevin B.
Hutchinson, Amy
Burdett, Laurie
Ghosh, Arpita
Thun, Michael J.
Gapstur, Susan M.
Ryan Diver, W.
Virtamo, Jarmo
Albanes, Demetrius
Cancel-Tassin, Geraldine
Valeri, Antoine
Cussenot, Olivier
Offit, Kenneth
Giovannucci, Ed
Ma, Jing
Stampfer, Meir J.
Michael Gaziano, J.
Hunter, David J.
Dutra-Clarke, Ana
Kirchhoff, Tomas
Alavanja, Michael
Freeman, Laura B.
Koutros, Stella
Hoover, Robert
Berndt, Sonja I.
Hayes, Richard B.
Agalliu, Ilir
Burk, Robert D.
Wacholder, Sholom
Thomas, Gilles
Amundadottir, Laufey
author_facet Wang, Zhaoming
Parikh, Hemang
Jia, Jinping
Myers, Timothy
Yeager, Meredith
Jacobs, Kevin B.
Hutchinson, Amy
Burdett, Laurie
Ghosh, Arpita
Thun, Michael J.
Gapstur, Susan M.
Ryan Diver, W.
Virtamo, Jarmo
Albanes, Demetrius
Cancel-Tassin, Geraldine
Valeri, Antoine
Cussenot, Olivier
Offit, Kenneth
Giovannucci, Ed
Ma, Jing
Stampfer, Meir J.
Michael Gaziano, J.
Hunter, David J.
Dutra-Clarke, Ana
Kirchhoff, Tomas
Alavanja, Michael
Freeman, Laura B.
Koutros, Stella
Hoover, Robert
Berndt, Sonja I.
Hayes, Richard B.
Agalliu, Ilir
Burk, Robert D.
Wacholder, Sholom
Thomas, Gilles
Amundadottir, Laufey
author_sort Wang, Zhaoming
collection PubMed
description Genetic variation on the Y chromosome has not been convincingly implicated in prostate cancer risk. To comprehensively analyze the role of inherited Y chromosome variation in prostate cancer risk in individuals of European ancestry, we genotyped 34 binary Y chromosome markers in 3,995 prostate cancer cases and 3,815 control subjects drawn from four studies. In this set, we identified nominally significant association between a rare haplogroup, E1b1b1c, and prostate cancer in stage I (P = 0.012, OR = 0.51; 95% confidence interval 0.30–0.87). Population substructure of E1b1b1c carriers suggested Ashkenazi Jewish ancestry, prompting a replication phase in individuals of both European and Ashkenazi Jewish ancestry. The association was not significant for prostate cancer overall in studies of either Ashkenazi Jewish (1,686 cases and 1,597 control subjects) or European (686 cases and 734 control subjects) ancestry (P (meta) = 0.078), but a meta-analysis of stage I and II studies revealed a nominally significant association with prostate cancer risk (P (meta) = 0.010, OR = 0.77; 95% confidence interval 0.62–0.94). Comparing haplogroup frequencies between studies, we noted strong similarities between those conducted in the US and France, in which the majority of men carried R1 haplogroups, resembling Northwestern European populations. On the other hand, Finns had a remarkably different haplogroup distribution with a preponderance of N1c and I1 haplogroups. In summary, our results suggest that inherited Y chromosome variation plays a limited role in prostate cancer etiology in European populations but warrant follow-up in additional large and well characterized studies of multiple ethnic backgrounds. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00439-012-1139-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-33741212012-06-14 Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry Wang, Zhaoming Parikh, Hemang Jia, Jinping Myers, Timothy Yeager, Meredith Jacobs, Kevin B. Hutchinson, Amy Burdett, Laurie Ghosh, Arpita Thun, Michael J. Gapstur, Susan M. Ryan Diver, W. Virtamo, Jarmo Albanes, Demetrius Cancel-Tassin, Geraldine Valeri, Antoine Cussenot, Olivier Offit, Kenneth Giovannucci, Ed Ma, Jing Stampfer, Meir J. Michael Gaziano, J. Hunter, David J. Dutra-Clarke, Ana Kirchhoff, Tomas Alavanja, Michael Freeman, Laura B. Koutros, Stella Hoover, Robert Berndt, Sonja I. Hayes, Richard B. Agalliu, Ilir Burk, Robert D. Wacholder, Sholom Thomas, Gilles Amundadottir, Laufey Hum Genet Original Investigation Genetic variation on the Y chromosome has not been convincingly implicated in prostate cancer risk. To comprehensively analyze the role of inherited Y chromosome variation in prostate cancer risk in individuals of European ancestry, we genotyped 34 binary Y chromosome markers in 3,995 prostate cancer cases and 3,815 control subjects drawn from four studies. In this set, we identified nominally significant association between a rare haplogroup, E1b1b1c, and prostate cancer in stage I (P = 0.012, OR = 0.51; 95% confidence interval 0.30–0.87). Population substructure of E1b1b1c carriers suggested Ashkenazi Jewish ancestry, prompting a replication phase in individuals of both European and Ashkenazi Jewish ancestry. The association was not significant for prostate cancer overall in studies of either Ashkenazi Jewish (1,686 cases and 1,597 control subjects) or European (686 cases and 734 control subjects) ancestry (P (meta) = 0.078), but a meta-analysis of stage I and II studies revealed a nominally significant association with prostate cancer risk (P (meta) = 0.010, OR = 0.77; 95% confidence interval 0.62–0.94). Comparing haplogroup frequencies between studies, we noted strong similarities between those conducted in the US and France, in which the majority of men carried R1 haplogroups, resembling Northwestern European populations. On the other hand, Finns had a remarkably different haplogroup distribution with a preponderance of N1c and I1 haplogroups. In summary, our results suggest that inherited Y chromosome variation plays a limited role in prostate cancer etiology in European populations but warrant follow-up in additional large and well characterized studies of multiple ethnic backgrounds. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00439-012-1139-5) contains supplementary material, which is available to authorized users. Springer-Verlag 2012-01-24 2012 /pmc/articles/PMC3374121/ /pubmed/22271044 http://dx.doi.org/10.1007/s00439-012-1139-5 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Investigation
Wang, Zhaoming
Parikh, Hemang
Jia, Jinping
Myers, Timothy
Yeager, Meredith
Jacobs, Kevin B.
Hutchinson, Amy
Burdett, Laurie
Ghosh, Arpita
Thun, Michael J.
Gapstur, Susan M.
Ryan Diver, W.
Virtamo, Jarmo
Albanes, Demetrius
Cancel-Tassin, Geraldine
Valeri, Antoine
Cussenot, Olivier
Offit, Kenneth
Giovannucci, Ed
Ma, Jing
Stampfer, Meir J.
Michael Gaziano, J.
Hunter, David J.
Dutra-Clarke, Ana
Kirchhoff, Tomas
Alavanja, Michael
Freeman, Laura B.
Koutros, Stella
Hoover, Robert
Berndt, Sonja I.
Hayes, Richard B.
Agalliu, Ilir
Burk, Robert D.
Wacholder, Sholom
Thomas, Gilles
Amundadottir, Laufey
Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry
title Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry
title_full Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry
title_fullStr Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry
title_full_unstemmed Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry
title_short Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry
title_sort y chromosome haplogroups and prostate cancer in populations of european and ashkenazi jewish ancestry
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374121/
https://www.ncbi.nlm.nih.gov/pubmed/22271044
http://dx.doi.org/10.1007/s00439-012-1139-5
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