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p97 complexes as signal integration hubs
In the ubiquitin-proteasome system, a subset of ubiquitylated proteins requires the AAA+ ATPase p97 (also known as VCP or Cdc48) for extraction from membranes or protein complexes before delivery to the proteasome for degradation. Diverse ubiquitin adapters are known to link p97 to its client protei...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374291/ https://www.ncbi.nlm.nih.gov/pubmed/22694940 http://dx.doi.org/10.1186/1741-7007-10-48 |
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author | Meyer, Hemmo |
author_facet | Meyer, Hemmo |
author_sort | Meyer, Hemmo |
collection | PubMed |
description | In the ubiquitin-proteasome system, a subset of ubiquitylated proteins requires the AAA+ ATPase p97 (also known as VCP or Cdc48) for extraction from membranes or protein complexes before delivery to the proteasome for degradation. Diverse ubiquitin adapters are known to link p97 to its client proteins, but two recent papers on the adapter protein UBXD7, including one by Bandau et al. in BMC Biology, suggest that rather than simply linking p97 to ubiquitylated proteins, this adapter may be essential to coordinate ubiquitylation and p97-mediated extraction of the proteasome substrate. These findings add to growing indications of richly diverse roles of adapters in p97-mediated signaling functions. See research article: http://www.biomedcentral.com/1741-7007/10/36 |
format | Online Article Text |
id | pubmed-3374291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-33742912012-06-13 p97 complexes as signal integration hubs Meyer, Hemmo BMC Biol Commentary In the ubiquitin-proteasome system, a subset of ubiquitylated proteins requires the AAA+ ATPase p97 (also known as VCP or Cdc48) for extraction from membranes or protein complexes before delivery to the proteasome for degradation. Diverse ubiquitin adapters are known to link p97 to its client proteins, but two recent papers on the adapter protein UBXD7, including one by Bandau et al. in BMC Biology, suggest that rather than simply linking p97 to ubiquitylated proteins, this adapter may be essential to coordinate ubiquitylation and p97-mediated extraction of the proteasome substrate. These findings add to growing indications of richly diverse roles of adapters in p97-mediated signaling functions. See research article: http://www.biomedcentral.com/1741-7007/10/36 BioMed Central 2012-06-13 /pmc/articles/PMC3374291/ /pubmed/22694940 http://dx.doi.org/10.1186/1741-7007-10-48 Text en Copyright ©2012 Meyer; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Commentary Meyer, Hemmo p97 complexes as signal integration hubs |
title | p97 complexes as signal integration hubs |
title_full | p97 complexes as signal integration hubs |
title_fullStr | p97 complexes as signal integration hubs |
title_full_unstemmed | p97 complexes as signal integration hubs |
title_short | p97 complexes as signal integration hubs |
title_sort | p97 complexes as signal integration hubs |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374291/ https://www.ncbi.nlm.nih.gov/pubmed/22694940 http://dx.doi.org/10.1186/1741-7007-10-48 |
work_keys_str_mv | AT meyerhemmo p97complexesassignalintegrationhubs |