Cargando…

Information Processing and Integration with Intracellular Dynamics Near Critical Point

Recent experimental observations suggest that cells can show relatively precise and reliable responses to external signals even though substantial noise is inevitably involved in the signals. An intriguing question is the way how cells can manage to do it. One possible way to realize such response f...

Descripción completa

Detalles Bibliográficos
Autores principales: Kamimura, Atsushi, Kobayashi, Tetsuya J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374347/
https://www.ncbi.nlm.nih.gov/pubmed/22707939
http://dx.doi.org/10.3389/fphys.2012.00203
_version_ 1782235632950575104
author Kamimura, Atsushi
Kobayashi, Tetsuya J.
author_facet Kamimura, Atsushi
Kobayashi, Tetsuya J.
author_sort Kamimura, Atsushi
collection PubMed
description Recent experimental observations suggest that cells can show relatively precise and reliable responses to external signals even though substantial noise is inevitably involved in the signals. An intriguing question is the way how cells can manage to do it. One possible way to realize such response for a cell is to evolutionary develop and optimize its intracellular signaling pathways so as to extract relevant information from the noisy signal. We recently demonstrated that certain intracellular signaling reactions could actually conduct statistically optimal information processing. In this paper, we clarify that such optimal reaction operates near bifurcation point. This result suggests that critical-like phenomena in the single-cell level may be linked to efficient information processing inside a cell. In addition, improving the performance of response in the single-cell level is not the only way for cells to realize reliable response. Another possible strategy is to integrate information of individual cells by cell-to-cell interaction such as quorum sensing. Since cell-to-cell interaction is a common phenomenon, it is equally important to investigate how cells can integrate their information by cell-to-cell interaction to realize efficient information processing in the population level. In this paper, we consider roles and benefits of cell-to-cell interaction by considering integrations of obtained information of individuals with the other cells from the viewpoint of information processing. We also demonstrate that, by introducing cell movement, spatial organizations can spontaneously emerge as a result of efficient responses of the population to external signals.
format Online
Article
Text
id pubmed-3374347
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Frontiers Research Foundation
record_format MEDLINE/PubMed
spelling pubmed-33743472012-06-15 Information Processing and Integration with Intracellular Dynamics Near Critical Point Kamimura, Atsushi Kobayashi, Tetsuya J. Front Physiol Physiology Recent experimental observations suggest that cells can show relatively precise and reliable responses to external signals even though substantial noise is inevitably involved in the signals. An intriguing question is the way how cells can manage to do it. One possible way to realize such response for a cell is to evolutionary develop and optimize its intracellular signaling pathways so as to extract relevant information from the noisy signal. We recently demonstrated that certain intracellular signaling reactions could actually conduct statistically optimal information processing. In this paper, we clarify that such optimal reaction operates near bifurcation point. This result suggests that critical-like phenomena in the single-cell level may be linked to efficient information processing inside a cell. In addition, improving the performance of response in the single-cell level is not the only way for cells to realize reliable response. Another possible strategy is to integrate information of individual cells by cell-to-cell interaction such as quorum sensing. Since cell-to-cell interaction is a common phenomenon, it is equally important to investigate how cells can integrate their information by cell-to-cell interaction to realize efficient information processing in the population level. In this paper, we consider roles and benefits of cell-to-cell interaction by considering integrations of obtained information of individuals with the other cells from the viewpoint of information processing. We also demonstrate that, by introducing cell movement, spatial organizations can spontaneously emerge as a result of efficient responses of the population to external signals. Frontiers Research Foundation 2012-06-13 /pmc/articles/PMC3374347/ /pubmed/22707939 http://dx.doi.org/10.3389/fphys.2012.00203 Text en Copyright © 2012 Kamimura and Kobayashi. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Physiology
Kamimura, Atsushi
Kobayashi, Tetsuya J.
Information Processing and Integration with Intracellular Dynamics Near Critical Point
title Information Processing and Integration with Intracellular Dynamics Near Critical Point
title_full Information Processing and Integration with Intracellular Dynamics Near Critical Point
title_fullStr Information Processing and Integration with Intracellular Dynamics Near Critical Point
title_full_unstemmed Information Processing and Integration with Intracellular Dynamics Near Critical Point
title_short Information Processing and Integration with Intracellular Dynamics Near Critical Point
title_sort information processing and integration with intracellular dynamics near critical point
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374347/
https://www.ncbi.nlm.nih.gov/pubmed/22707939
http://dx.doi.org/10.3389/fphys.2012.00203
work_keys_str_mv AT kamimuraatsushi informationprocessingandintegrationwithintracellulardynamicsnearcriticalpoint
AT kobayashitetsuyaj informationprocessingandintegrationwithintracellulardynamicsnearcriticalpoint