Towards an understating of signal transduction protein interaction networks

Protein network analysis has witnessed a number of advancements in the past for understanding molecular characteristics for important network topologies in biological systems. The signaling pathway regulates cell cycle progression and anti-apoptotic molecules. This pathway is also involved in mainta...

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Detalles Bibliográficos
Autores principales: Kaladhar, Dowluru SVGK, Sai, Potladurthi Chandra, Rao, Padmanabhuni V Nageswara, chaitanya, Amajala Krishna, Rao, Duddukuri Govinda, Rao, Vadlapudi Varahala, Reddy, Erva Rajeswara, kumar, Sudabattula Vijaya, Kumar, Divyakolu Vinod
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374375/
https://www.ncbi.nlm.nih.gov/pubmed/22715315
http://dx.doi.org/10.6026/97320630008437
Descripción
Sumario:Protein network analysis has witnessed a number of advancements in the past for understanding molecular characteristics for important network topologies in biological systems. The signaling pathway regulates cell cycle progression and anti-apoptotic molecules. This pathway is also involved in maintaining cell survival by modulating the activity of apoptosis through RAS, P13K, AKT and BAD activities. The importance of protein-protein interactions to improve usability of the interactome by scoring and ranking interaction data for proteins in signal transduction networks is illustrated using available data and resources.

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