Mice with an induced mutation in collagen 8A2 develop larger eyes and are resistant to retinal ganglion cell damage in an experimental glaucoma model

PURPOSE: To study susceptibility to glaucoma injury as it may be affected by mutations in ocular connective tissue components. METHODS: Mice homozygous for an N-ethyl-N-nitrosourea induced G257D exchange (Gly to Asp) missense mutation (Aca23) in their collagen 8A2 gene were studied to measure intrao...

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Autores principales: Steinhart, Matthew R., Cone, Frances E., Nguyen, Cathy, Nguyen, Thao D., Pease, Mary E., Puk, Oliver, Graw, Jochen, Oglesby, Ericka N., Quigley, Harry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374490/
https://www.ncbi.nlm.nih.gov/pubmed/22701298

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