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Transdermal Delivery of Venlafaxine Hydrochloride: The Effects of Enhancers on Permeation Across Pig Ear Skin
Venlafaxine representing a new class of antidepressants is a potent serotonin/ norepinephrine reuptake inhibitor. Transdermal delivery of venlafaxine hydrochloride (VHCl) may result in proper patient compliance by reducing the incidence of the undesirable GI problems generally associated with its pl...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374566/ https://www.ncbi.nlm.nih.gov/pubmed/22707834 http://dx.doi.org/10.4103/0250-474X.95650 |
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author | Vijaya, C. Bingi, Manasa Vigneshwaran, L. V. |
author_facet | Vijaya, C. Bingi, Manasa Vigneshwaran, L. V. |
author_sort | Vijaya, C. |
collection | PubMed |
description | Venlafaxine representing a new class of antidepressants is a potent serotonin/ norepinephrine reuptake inhibitor. Transdermal delivery of venlafaxine hydrochloride (VHCl) may result in proper patient compliance by reducing the incidence of the undesirable GI problems generally associated with its plural oral dosing. The present study is an attempt to investigate the improvement of the transdermal flux of the hydrophilic VHCl by certain permeation enhancers viz. glycerin, urea, propylene glycol and mixture of propylene glycol and ethanol across pig ear skin. The cumulative drug release was the highest from the formulation F5 consisting of the mixture of propylene glycol and ethanol in sodium alginate gel with a load of 25% w/w VHCl with 96% permeation enhancement. The steady state flux observed with F5 was 0.203 mg cm(-2) hr and an area of 15.27 cm(2) would suffice to arrive at a required therapeutic concentration of VHCl in the blood. |
format | Online Article Text |
id | pubmed-3374566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33745662012-06-15 Transdermal Delivery of Venlafaxine Hydrochloride: The Effects of Enhancers on Permeation Across Pig Ear Skin Vijaya, C. Bingi, Manasa Vigneshwaran, L. V. Indian J Pharm Sci Short Communication Venlafaxine representing a new class of antidepressants is a potent serotonin/ norepinephrine reuptake inhibitor. Transdermal delivery of venlafaxine hydrochloride (VHCl) may result in proper patient compliance by reducing the incidence of the undesirable GI problems generally associated with its plural oral dosing. The present study is an attempt to investigate the improvement of the transdermal flux of the hydrophilic VHCl by certain permeation enhancers viz. glycerin, urea, propylene glycol and mixture of propylene glycol and ethanol across pig ear skin. The cumulative drug release was the highest from the formulation F5 consisting of the mixture of propylene glycol and ethanol in sodium alginate gel with a load of 25% w/w VHCl with 96% permeation enhancement. The steady state flux observed with F5 was 0.203 mg cm(-2) hr and an area of 15.27 cm(2) would suffice to arrive at a required therapeutic concentration of VHCl in the blood. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3374566/ /pubmed/22707834 http://dx.doi.org/10.4103/0250-474X.95650 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Vijaya, C. Bingi, Manasa Vigneshwaran, L. V. Transdermal Delivery of Venlafaxine Hydrochloride: The Effects of Enhancers on Permeation Across Pig Ear Skin |
title | Transdermal Delivery of Venlafaxine Hydrochloride: The Effects of Enhancers on Permeation Across Pig Ear Skin |
title_full | Transdermal Delivery of Venlafaxine Hydrochloride: The Effects of Enhancers on Permeation Across Pig Ear Skin |
title_fullStr | Transdermal Delivery of Venlafaxine Hydrochloride: The Effects of Enhancers on Permeation Across Pig Ear Skin |
title_full_unstemmed | Transdermal Delivery of Venlafaxine Hydrochloride: The Effects of Enhancers on Permeation Across Pig Ear Skin |
title_short | Transdermal Delivery of Venlafaxine Hydrochloride: The Effects of Enhancers on Permeation Across Pig Ear Skin |
title_sort | transdermal delivery of venlafaxine hydrochloride: the effects of enhancers on permeation across pig ear skin |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374566/ https://www.ncbi.nlm.nih.gov/pubmed/22707834 http://dx.doi.org/10.4103/0250-474X.95650 |
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