Development and Validation of Simple Titrimetric Method for the Determination of Magnesium Content in Esomeprazole Magnesium

A simple and inexpensive titrimetric method for the determination of magnesium ion in esomeprazole magnesium raw material was developed and validated according to International Conference on Harmonization guidelines and the United States Pharmacopoeia. The method depends on complex formation between...

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Detalles Bibliográficos
Autores principales: Haddadin, R. N., Issa, A. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374569/
https://www.ncbi.nlm.nih.gov/pubmed/22707837
http://dx.doi.org/10.4103/0250-474X.95653
Descripción
Sumario:A simple and inexpensive titrimetric method for the determination of magnesium ion in esomeprazole magnesium raw material was developed and validated according to International Conference on Harmonization guidelines and the United States Pharmacopoeia. The method depends on complex formation between EDTA and magnesium ion. The method was proven to be valid, equivalent and useful as an alternative method to the current pharmacopeial methods that are based on atomic absorption spectrometry.

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