Development and Validation of Simple Titrimetric Method for the Determination of Magnesium Content in Esomeprazole Magnesium

A simple and inexpensive titrimetric method for the determination of magnesium ion in esomeprazole magnesium raw material was developed and validated according to International Conference on Harmonization guidelines and the United States Pharmacopoeia. The method depends on complex formation between...

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Detalles Bibliográficos
Autores principales: Haddadin, R. N., Issa, A. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374569/
https://www.ncbi.nlm.nih.gov/pubmed/22707837
http://dx.doi.org/10.4103/0250-474X.95653
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author Haddadin, R. N.
Issa, A. Y.
author_facet Haddadin, R. N.
Issa, A. Y.
author_sort Haddadin, R. N.
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description A simple and inexpensive titrimetric method for the determination of magnesium ion in esomeprazole magnesium raw material was developed and validated according to International Conference on Harmonization guidelines and the United States Pharmacopoeia. The method depends on complex formation between EDTA and magnesium ion. The method was proven to be valid, equivalent and useful as an alternative method to the current pharmacopeial methods that are based on atomic absorption spectrometry.
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spelling pubmed-33745692012-06-15 Development and Validation of Simple Titrimetric Method for the Determination of Magnesium Content in Esomeprazole Magnesium Haddadin, R. N. Issa, A. Y. Indian J Pharm Sci Short Communication A simple and inexpensive titrimetric method for the determination of magnesium ion in esomeprazole magnesium raw material was developed and validated according to International Conference on Harmonization guidelines and the United States Pharmacopoeia. The method depends on complex formation between EDTA and magnesium ion. The method was proven to be valid, equivalent and useful as an alternative method to the current pharmacopeial methods that are based on atomic absorption spectrometry. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3374569/ /pubmed/22707837 http://dx.doi.org/10.4103/0250-474X.95653 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Haddadin, R. N.
Issa, A. Y.
Development and Validation of Simple Titrimetric Method for the Determination of Magnesium Content in Esomeprazole Magnesium
title Development and Validation of Simple Titrimetric Method for the Determination of Magnesium Content in Esomeprazole Magnesium
title_full Development and Validation of Simple Titrimetric Method for the Determination of Magnesium Content in Esomeprazole Magnesium
title_fullStr Development and Validation of Simple Titrimetric Method for the Determination of Magnesium Content in Esomeprazole Magnesium
title_full_unstemmed Development and Validation of Simple Titrimetric Method for the Determination of Magnesium Content in Esomeprazole Magnesium
title_short Development and Validation of Simple Titrimetric Method for the Determination of Magnesium Content in Esomeprazole Magnesium
title_sort development and validation of simple titrimetric method for the determination of magnesium content in esomeprazole magnesium
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374569/
https://www.ncbi.nlm.nih.gov/pubmed/22707837
http://dx.doi.org/10.4103/0250-474X.95653
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