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In silico modeling of the pore region of a KCNQ4 missense mutant from a patient with hearing loss
BACKGROUND: Mutation of the voltage-gated potassium channel KCNQ4 causes DFNA2-type nonsyndromic autosomal dominant sensorineural hearing loss. KCNQ4 is expressed predominantly in the auditory sensory outer hair cells, which are critical for sound amplification. RESULTS: We sequenced KCNQ4 from Japa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374714/ https://www.ncbi.nlm.nih.gov/pubmed/22420747 http://dx.doi.org/10.1186/1756-0500-5-145 |