Cargando…

Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing

The β-site amyloid precursor protein (APP)–cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease that catalyzes the proteolytic processing of APP and other plasma membrane protein precursors. BACE1 cycles between the trans-Golgi network (TGN), the plasma membrane, and endosomes by virtue of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prabhu, Yogikala, Burgos, Patricia V., Schindler, Christina, Farías, Ginny G., Magadár, Javier G., Bonifacino, Juan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374752/ https://www.ncbi.nlm.nih.gov/pubmed/22553349 http://dx.doi.org/10.1091/mbc.E11-11-0944

Ejemplares similares

Correction for Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing
Publicado: (2012)

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
por: Scholefield, Zoe, et al.
Publicado: (2003)

Secretases Related to Amyloid Precursor Protein Processing
por: Liu, Xiaoling, et al.
Publicado: (2021)

Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase
por: Hogl, Sebastian, et al.
Publicado: (2011)

Clathrin-Mediated Endocytosis and Adaptor Proteins
por: Popova, N.V., et al.
Publicado: (2013)

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
por: Weber, Tobias A., et al.
Publicado: (2021)

Novel Adaptors of Amyloid Precursor Protein Intracellular Domain and Their Functional Implications
por: Chakrabarti, Arunabha, et al.
Publicado: (2012)

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
por: Basi, Guriqbal S, et al.
Publicado: (2010)

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease
por: Zhang, Zhentao, et al.
Publicado: (2015)

A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase
por: Lu, Xiaoli, et al.
Publicado: (2022)

Attenuated ability of BACE1 to cleave the amyloid precursor protein via silencing long noncoding RNA BACE1-AS expression
por: LIU, TE, et al.
Publicado: (2014)

Adaptor proteins involved in polarized sorting
por: Bonifacino, Juan S.
Publicado: (2014)

Divalent cation tolerance protein binds to β-secretase and inhibits the processing of amyloid precursor protein☆
por: Liu, Runzhong, et al.
Publicado: (2013)

Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation
por: Jin, Chen, et al.
Publicado: (2022)

Clathrin adaptor AP-1–mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments
por: Januário, Yunan C., et al.
Publicado: (2022)

The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
por: Cupers, Philippe, et al.
Publicado: (2001)

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity
por: Jung, Joo In, et al.
Publicado: (2014)

Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing()
por: Cox, Carla J., et al.
Publicado: (2015)

Segregation of the membrane cargoes, BACE1 and amyloid precursor protein (APP) throughout the Golgi apparatus
por: Fourriere, Lou, et al.
Publicado: (2022)

Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol
por: Rudajev, Vladimir, et al.
Publicado: (2023)

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites
por: Yan, Yan, et al.
Publicado: (2017)

Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production
por: Tan, Jing Zhi A., et al.
Publicado: (2020)

The Alzheimer's disease β-secretase enzyme, BACE1
por: Cole, Sarah L, et al.
Publicado: (2007)

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
por: Lessard, Christian B., et al.
Publicado: (2015)

Justicidin A Reduces β-Amyloid via Inhibiting Endocytosis of β-Amyloid Precursor Protein
por: Chun, Yoon Sun, et al.
Publicado: (2019)

The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by α-secretase ADAM10
por: Hitschler, Lisa, et al.
Publicado: (2022)

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing
por: Niederst, Emily D., et al.
Publicado: (2015)

γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production
por: Takami, Mako, et al.
Publicado: (2012)

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid β protein
por: Carey, Robyn M, et al.
Publicado: (2005)

Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons
por: Annaert, Wim G., et al.
Publicado: (1999)

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase
por: Morishima-Kawashima, Maho
Publicado: (2014)

Verteporfin is a substrate-selective γ-secretase inhibitor that binds the amyloid precursor protein transmembrane domain
por: Castro, Manuel A., et al.
Publicado: (2022)

BACE1, the Alzheimer's beta-secretase enzyme, in health and disease
por: Vassar, Robert
Publicado: (2012)

BACE1, the Alzheimer’s beta-secretase enzyme, in health and disease
por: Vassar, Robert
Publicado: (2013)

BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer’s Disease
por: Maia, Miguel A., et al.
Publicado: (2019)

BACE1: More than just a β‐secretase
por: Taylor, Hannah A., et al.
Publicado: (2022)

Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production
por: Suzuki, Ryota, et al.
Publicado: (2023)

Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains
por: Cho, Yoon Young, et al.
Publicado: (2020)

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease
por: Serneels, Lutgarde, et al.
Publicado: (2020)

β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage
por: Portelius, Erik, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_qruot3cj3e23d3at14dh3r985u