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Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing

The β-site amyloid precursor protein (APP)–cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease that catalyzes the proteolytic processing of APP and other plasma membrane protein precursors. BACE1 cycles between the trans-Golgi network (TGN), the plasma membrane, and endosomes by virtue of...

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Detalles Bibliográficos
Autores principales:	Prabhu, Yogikala, Burgos, Patricia V., Schindler, Christina, Farías, Ginny G., Magadár, Javier G., Bonifacino, Juan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374752/ https://www.ncbi.nlm.nih.gov/pubmed/22553349 http://dx.doi.org/10.1091/mbc.E11-11-0944

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