Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation

OBJECTIVE: Mutations in matrilin 3 can result in multiple epiphyseal dysplasia (MED), a disease characterized by delayed and irregular bone growth and early-onset osteoarthritis. Although intracellular retention of the majority of mutant matrilin 3 was previously observed in a murine model of MED ca...

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Detalles Bibliográficos
Autores principales: Bell, Peter A, Piróg, Katarzyna A, Fresquet, Maryline, Thornton, David J, Boot-Handford, Raymond P, Briggs, Michael D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:
Bone Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374853/
https://www.ncbi.nlm.nih.gov/pubmed/22083516
http://dx.doi.org/10.1002/art.33486

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