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The Influence of Type 2 Diabetes and Glucose-Lowering Therapies on Cancer Risk in the Taiwanese

Objective. To investigate the association between type 2 diabetes, glucose-lowering therapies (monotherapy with either metformin, sulphonylurea or insulin) and cancer risk in Taiwan. Methods. Using Taiwan's National Health Research Institutes database of 1,000,000 random subjects from 2000–2008...

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Autores principales: Hsieh, Ming-Chia, Lee, Tzu-Chi, Cheng, Shu-Min, Tu, Shih-Te, Yen, Ming-Hong, Tseng, Chin-Hsiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374948/
https://www.ncbi.nlm.nih.gov/pubmed/22719752
http://dx.doi.org/10.1155/2012/413782
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author Hsieh, Ming-Chia
Lee, Tzu-Chi
Cheng, Shu-Min
Tu, Shih-Te
Yen, Ming-Hong
Tseng, Chin-Hsiao
author_facet Hsieh, Ming-Chia
Lee, Tzu-Chi
Cheng, Shu-Min
Tu, Shih-Te
Yen, Ming-Hong
Tseng, Chin-Hsiao
author_sort Hsieh, Ming-Chia
collection PubMed
description Objective. To investigate the association between type 2 diabetes, glucose-lowering therapies (monotherapy with either metformin, sulphonylurea or insulin) and cancer risk in Taiwan. Methods. Using Taiwan's National Health Research Institutes database of 1,000,000 random subjects from 2000–2008, we found 61777 patients with type 2 diabetes (age ≥20 years) and 677378 enrollees with no record of diabetes. Results. After adjusting for age and sex, we found patients with diabetes to have significantly higher risk of all cancers (OR: 1.176; 95% CI: 1.149–1.204, P < 0.001). Diabetic patients treated with insulin or sulfonylureas had significantly higher risk of all cancers, compared to those treated with metformin (OR: 1.583; 95% CI: 1.389–1.805, P < 0.001 and OR: 1.784; 95% CI: 1.406–2.262, P < 0.001). Metformin treatment was associated with a decreased risk of colon and liver cancer compared to sulphonylureas or insulin treatment. Sulfonylureas treatment was associated with an increased risk of breast and lung cancer compared to metformin therapy. Conclusions. Taiwanese with type 2 diabetes are at a high risk of breast, prostate, colon, lung, liver and pancreatic cancer. Those treated with insulin or sulfonylureas monotherapy are more likely to develop colon and liver cancer than those treated with metformin.
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spelling pubmed-33749482012-06-20 The Influence of Type 2 Diabetes and Glucose-Lowering Therapies on Cancer Risk in the Taiwanese Hsieh, Ming-Chia Lee, Tzu-Chi Cheng, Shu-Min Tu, Shih-Te Yen, Ming-Hong Tseng, Chin-Hsiao Exp Diabetes Res Research Article Objective. To investigate the association between type 2 diabetes, glucose-lowering therapies (monotherapy with either metformin, sulphonylurea or insulin) and cancer risk in Taiwan. Methods. Using Taiwan's National Health Research Institutes database of 1,000,000 random subjects from 2000–2008, we found 61777 patients with type 2 diabetes (age ≥20 years) and 677378 enrollees with no record of diabetes. Results. After adjusting for age and sex, we found patients with diabetes to have significantly higher risk of all cancers (OR: 1.176; 95% CI: 1.149–1.204, P < 0.001). Diabetic patients treated with insulin or sulfonylureas had significantly higher risk of all cancers, compared to those treated with metformin (OR: 1.583; 95% CI: 1.389–1.805, P < 0.001 and OR: 1.784; 95% CI: 1.406–2.262, P < 0.001). Metformin treatment was associated with a decreased risk of colon and liver cancer compared to sulphonylureas or insulin treatment. Sulfonylureas treatment was associated with an increased risk of breast and lung cancer compared to metformin therapy. Conclusions. Taiwanese with type 2 diabetes are at a high risk of breast, prostate, colon, lung, liver and pancreatic cancer. Those treated with insulin or sulfonylureas monotherapy are more likely to develop colon and liver cancer than those treated with metformin. Hindawi Publishing Corporation 2012 2012-06-05 /pmc/articles/PMC3374948/ /pubmed/22719752 http://dx.doi.org/10.1155/2012/413782 Text en Copyright © 2012 Ming-Chia Hsieh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hsieh, Ming-Chia
Lee, Tzu-Chi
Cheng, Shu-Min
Tu, Shih-Te
Yen, Ming-Hong
Tseng, Chin-Hsiao
The Influence of Type 2 Diabetes and Glucose-Lowering Therapies on Cancer Risk in the Taiwanese
title The Influence of Type 2 Diabetes and Glucose-Lowering Therapies on Cancer Risk in the Taiwanese
title_full The Influence of Type 2 Diabetes and Glucose-Lowering Therapies on Cancer Risk in the Taiwanese
title_fullStr The Influence of Type 2 Diabetes and Glucose-Lowering Therapies on Cancer Risk in the Taiwanese
title_full_unstemmed The Influence of Type 2 Diabetes and Glucose-Lowering Therapies on Cancer Risk in the Taiwanese
title_short The Influence of Type 2 Diabetes and Glucose-Lowering Therapies on Cancer Risk in the Taiwanese
title_sort influence of type 2 diabetes and glucose-lowering therapies on cancer risk in the taiwanese
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374948/
https://www.ncbi.nlm.nih.gov/pubmed/22719752
http://dx.doi.org/10.1155/2012/413782
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