Amniotic Fluid Stem Cells: Future Perspectives

The existence of stem cells in human amniotic fluid was reported for the first time almost ten years ago. Since this discovery, the knowledge about these cells has increased dramatically. Today, amniotic fluid stem (AFS) cells are widely accepted as a new powerful tool for basic research as well as...

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Autores principales: Rosner, Margit, Schipany, Katharina, Shanmugasundaram, Bharanidharan, Lubec, Gert, Hengstschläger, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375114/
https://www.ncbi.nlm.nih.gov/pubmed/22719774
http://dx.doi.org/10.1155/2012/741810
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author Rosner, Margit
Schipany, Katharina
Shanmugasundaram, Bharanidharan
Lubec, Gert
Hengstschläger, Markus
author_facet Rosner, Margit
Schipany, Katharina
Shanmugasundaram, Bharanidharan
Lubec, Gert
Hengstschläger, Markus
author_sort Rosner, Margit
collection PubMed
description The existence of stem cells in human amniotic fluid was reported for the first time almost ten years ago. Since this discovery, the knowledge about these cells has increased dramatically. Today, amniotic fluid stem (AFS) cells are widely accepted as a new powerful tool for basic research as well as for the establishment of new stem-cell-based therapy concepts. It is possible to generate monoclonal genomically stable AFS cell lines harboring high proliferative potential without raising ethical issues. Many different groups have demonstrated that AFS cells can be differentiated into all three germ layer lineages, what is of relevance for both, the scientific and therapeutical usage of these cells. Of special importance for the latter is the fact that AFS cells are less tumorigenic than other pluripotent stem cell types. In this paper, we have summarized the current knowledge about this relatively young scientific field. Furthermore, we discuss the relevant future perspectives of this promising area of stem cell research focusing on the next important questions, which need to be answered.
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spelling pubmed-33751142012-06-20 Amniotic Fluid Stem Cells: Future Perspectives Rosner, Margit Schipany, Katharina Shanmugasundaram, Bharanidharan Lubec, Gert Hengstschläger, Markus Stem Cells Int Review Article The existence of stem cells in human amniotic fluid was reported for the first time almost ten years ago. Since this discovery, the knowledge about these cells has increased dramatically. Today, amniotic fluid stem (AFS) cells are widely accepted as a new powerful tool for basic research as well as for the establishment of new stem-cell-based therapy concepts. It is possible to generate monoclonal genomically stable AFS cell lines harboring high proliferative potential without raising ethical issues. Many different groups have demonstrated that AFS cells can be differentiated into all three germ layer lineages, what is of relevance for both, the scientific and therapeutical usage of these cells. Of special importance for the latter is the fact that AFS cells are less tumorigenic than other pluripotent stem cell types. In this paper, we have summarized the current knowledge about this relatively young scientific field. Furthermore, we discuss the relevant future perspectives of this promising area of stem cell research focusing on the next important questions, which need to be answered. Hindawi Publishing Corporation 2012 2012-06-06 /pmc/articles/PMC3375114/ /pubmed/22719774 http://dx.doi.org/10.1155/2012/741810 Text en Copyright © 2012 Margit Rosner et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rosner, Margit
Schipany, Katharina
Shanmugasundaram, Bharanidharan
Lubec, Gert
Hengstschläger, Markus
Amniotic Fluid Stem Cells: Future Perspectives
title Amniotic Fluid Stem Cells: Future Perspectives
title_full Amniotic Fluid Stem Cells: Future Perspectives
title_fullStr Amniotic Fluid Stem Cells: Future Perspectives
title_full_unstemmed Amniotic Fluid Stem Cells: Future Perspectives
title_short Amniotic Fluid Stem Cells: Future Perspectives
title_sort amniotic fluid stem cells: future perspectives
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375114/
https://www.ncbi.nlm.nih.gov/pubmed/22719774
http://dx.doi.org/10.1155/2012/741810
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