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Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP)

Paratuberculosis progresses more quickly in young red deer than in sheep or cattle. This study describes the clinical, immunological and pathological changes over a 50-week period in fourteen 4-month-old red deer that received heavy oral challenge with Mycobacterium avium subsp. paratuberculosis (MA...

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Detalles Bibliográficos
Autores principales: Mackintosh, Colin, Clark, Gary, Tolentino, Brendan, Liggett, Simon, de Lisle, Geoff, Griffin, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375165/
https://www.ncbi.nlm.nih.gov/pubmed/22720193
http://dx.doi.org/10.1155/2012/931948
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author Mackintosh, Colin
Clark, Gary
Tolentino, Brendan
Liggett, Simon
de Lisle, Geoff
Griffin, Frank
author_facet Mackintosh, Colin
Clark, Gary
Tolentino, Brendan
Liggett, Simon
de Lisle, Geoff
Griffin, Frank
author_sort Mackintosh, Colin
collection PubMed
description Paratuberculosis progresses more quickly in young red deer than in sheep or cattle. This study describes the clinical, immunological and pathological changes over a 50-week period in fourteen 4-month-old red deer that received heavy oral challenge with Mycobacterium avium subsp. paratuberculosis (MAP). At 4 and 12 weeks post challenge they were anaesthetized and a section of jejunal lymph node was surgically removed for culture, histopathology, and genetic studies. All 14 deer became infected, none were clinically affected, and they had varying degrees of subclinical disease when killed at week 50. Week 4 biopsies showed no paratuberculosis lesions, but MAP was cultured from all animals. At weeks 12 and 50 histopathological lesions ranged from mild to severe with corresponding low-to-high antibody titres, which peaked at 12–24 weeks. IFN-γ responses peaked at 8–15 weeks and were higher in mildly affected animals than in those with severe lesions.
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spelling pubmed-33751652012-06-20 Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP) Mackintosh, Colin Clark, Gary Tolentino, Brendan Liggett, Simon de Lisle, Geoff Griffin, Frank Vet Med Int Research Article Paratuberculosis progresses more quickly in young red deer than in sheep or cattle. This study describes the clinical, immunological and pathological changes over a 50-week period in fourteen 4-month-old red deer that received heavy oral challenge with Mycobacterium avium subsp. paratuberculosis (MAP). At 4 and 12 weeks post challenge they were anaesthetized and a section of jejunal lymph node was surgically removed for culture, histopathology, and genetic studies. All 14 deer became infected, none were clinically affected, and they had varying degrees of subclinical disease when killed at week 50. Week 4 biopsies showed no paratuberculosis lesions, but MAP was cultured from all animals. At weeks 12 and 50 histopathological lesions ranged from mild to severe with corresponding low-to-high antibody titres, which peaked at 12–24 weeks. IFN-γ responses peaked at 8–15 weeks and were higher in mildly affected animals than in those with severe lesions. Hindawi Publishing Corporation 2012 2012-06-06 /pmc/articles/PMC3375165/ /pubmed/22720193 http://dx.doi.org/10.1155/2012/931948 Text en Copyright © 2012 Colin Mackintosh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mackintosh, Colin
Clark, Gary
Tolentino, Brendan
Liggett, Simon
de Lisle, Geoff
Griffin, Frank
Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP)
title Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP)
title_full Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP)
title_fullStr Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP)
title_full_unstemmed Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP)
title_short Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP)
title_sort longitudinal pathogenesis study of young red deer (cervus elaphus) after experimental challenge with mycobacterium avium subsp. paratuberculosis (map)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375165/
https://www.ncbi.nlm.nih.gov/pubmed/22720193
http://dx.doi.org/10.1155/2012/931948
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