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Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis

BACKGROUND/AIMS: We evaluated clinicopathological correlates of upper motor neuron (UMN) damage in amyotrophic lateral sclerosis (ALS), and analyzed if the presence of the C9ORF72 repeat expansion was associated with alterations in microglial inflammatory activity. METHODS: Microglial pathology was...

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Detalles Bibliográficos
Autores principales:	Brettschneider, Johannes, Toledo, Jon B., Van Deerlin, Vivianna M., Elman, Lauren, McCluskey, Leo, Lee, Virginia M.-Y., Trojanowski, John Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375234/ https://www.ncbi.nlm.nih.gov/pubmed/22720079 http://dx.doi.org/10.1371/journal.pone.0039216

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